公开(公告)号：EP2483250A1

公开(公告)日：2012-08-08

申请号：EP10820956.0

申请日：2010-02-04

Applicant: ScinoPharm Taiwan Ltd.

Inventor： HENSCHKE, Julian, Paul ,  ZHANG, Xiaoheng ,  YU, Jianbo ,  HU, Kun ,  MEI, Lijun

IPC: C07D251/02 ,  C07H19/12

CPC classification number: C07H13/08 ,  C07H19/12

Abstract: A method for producing a β-enriched protected decitabine comprising: a) coupling a protected 2-deoxy-ribofuranose with a protected 5-azacytosine in the presence of a catalyst to form a reaction mixture comprising the protected decitabine of formula (I); and b) quenching the reaction mixture of step a) with a base. The β-enriched protected decitabine so made may be deprotected to produce a decitabine product in a high yield and purity.

Abstract translation: 一种生产富含β-受保护的地西他滨的方法，包括：a）在催化剂存在下，将受保护的2-脱氧 - 呋喃核糖与受保护的5-氮杂胞嘧啶偶联，以形成包含式（I）的受保护的地西他滨的反应混合物; 和b）用碱淬灭步骤a）的反应混合物。 如此制得的富含β的受保护的地西他滨可以脱保护以高产率和高纯度产生地西他滨产物。

公开(公告)号：EP2440676A2

公开(公告)日：2012-04-18

申请号：EP10785817.7

申请日：2010-06-10

Applicant: ScinoPharm Taiwan Ltd.

Inventor： LIU, Wei-Kuang ,  DING, Min-Pey

IPC: C12Q1/68 ,  C12N15/63 ,  C12N15/113

CPC classification number: C12N15/1086 ,  C07K2319/60 ,  C12N15/85 ,  C12N2840/203 ,  C40B50/06

Abstract: A method for screening cells with high level expression of a target protein is disclosed. The method includes introducing into a plurality of host cells a DNA construct that encodes both a target protein and an inhibitor to an endogenous selectable marker in the host cells, screening host cells harboring the DNA construct for the expression of the endogenous selectable marker, and isolating cells with reduced expression of the selectable marker. Also disclosed is a DNA construct configured to express both the target protein and the inhibitor inside the host cell.

Abstract translation: 公开了一种筛选具有高水平表达靶蛋白的细胞的方法。 该方法包括向宿主细胞中引入编码靶蛋白和抑制剂两者的DNA构建体到内源选择标记，筛选携带DNA构建体以表达内源选择标记的宿主细胞，和分离 具有降低的选择标记表达的细胞。 还公开了配置为在宿主细胞内表达靶蛋白和抑制剂的DNA构建体。

公开(公告)号：EP2349307A4

公开(公告)日：2012-03-21

申请号：EP09812204

申请日：2009-09-03

Applicant: SCINOPHARM TAIWAN LTD

Inventor： HSIAO TSUNG YU ,  DING JIN GUO ,  CHUANG HUNG WEI

IPC: C07K1/00 ,  A61K38/00 ,  C07K7/06

CPC classification number: C07K14/815 ,  C07K7/06

公开(公告)号：EP1383754B1

公开(公告)日：2011-02-23

申请号：EP01924282.5

申请日：2001-03-23

Applicant: ScinoPharm Taiwan, Ltd.

Inventor： Schloemer, George ,  Chen, Yung-Fa ,  Lin, Chien Hsin ,  Daniewski, Wlodzimierz

IPC: C07D305/14 ,  C07D413/12

CPC classification number: C07D413/12 ,  C07D263/06 ,  C07D305/14

Abstract: The present invention provides a novel semi-synthetic method of producing a variety of novel taxane derivatives. The method involves the reaction of a phenylisoserine derivative with a suitably blocked Baccatin III derivative to produce a taxane substrate that may be further modified to form Pactitaxel and other potentially useful taxane derivatives.

公开(公告)号：EP2274266A2

公开(公告)日：2011-01-19

申请号：EP09750175.3

申请日：2009-04-09

Applicant: ScinoPharm Taiwan, Ltd.

Inventor： HENSCHKE, Julian ,  LIU, Yuanlian ,  CHEN, Yung-Fa ,  MENG, Dechao ,  SUN, Ting

IPC: C07C67/28 ,  C07C69/732 ,  C07C69/73 ,  C07D307/46 ,  A61K31/215 ,  A61K31/341

CPC classification number: C07C67/31 ,  C07B2200/07 ,  C07C67/333 ,  C07C231/14 ,  C07C405/0008 ,  C07C2601/10 ,  C07D307/54 ,  Y02P20/55 ,  C07C69/738

Abstract: [00110] The present application provides intermediates for preparing prostaglandin analogues and processes for preparing prostaglandin analogues and intermediates thereof. The intermediates include: A compound of formula (6) Ri represents H, C
1 -C
5 -alkyl, or benzyl, in particular isopropyl.

Abstract translation: 本申请提供用于制备前列腺素类似物及其制备前列腺素类似物及其中间体的中间体。 所述中间体包括：下式的化合物（6）：R 1表示H，C1-C5烷基，或苄基，特别是异丙基。

公开(公告)号：EP2170328A2

公开(公告)日：2010-04-07

申请号：EP08768769.5

申请日：2008-06-24

Applicant: ScinoPharm Taiwan, Ltd.

Inventor： CHEN, Weiyu ,  CHEN, Shu-ping ,  WANG, Sinchi

IPC: A61K31/4427 ,  A61K31/44 ,  C07D405/06 ,  C07D213/00

CPC classification number: C07J1/0011

Abstract: New crystalline polymorph of exemestane characterized by a powder X-ray diffraction pattern having peaks at 10.7±0.1, 15.9±0.1, and 18.1 ±0.1 2- theta degree.

公开(公告)号：EP1670767A4

公开(公告)日：2007-08-29

申请号：EP04789228

申请日：2004-09-27

Applicant: SCINOPHARM TAIWAN LTD

Inventor： SCHLOEMER GEORGE ,  HSIAO TSUNG-YU

IPC: C07D223/14 ,  A61K31/55 ,  C07D491/06

CPC classification number: C07D491/06

Abstract: The present invention provides for an efficient method of effecting the resolution of a narwedine amide, and the synthesis of galantamine.

Abstract translation: 本发明提供了一种有效的方法来实现Narwedine酰胺的拆分以及加兰他敏的合成。

公开(公告)号：EP1628982A4

公开(公告)日：2006-11-29

申请号：EP04751971

申请日：2004-05-12

Applicant: SCINOPHARM TAIWAN LTD

Inventor： LIN CHIEN-HSING ,  CHENG YUNG-FA ,  CHENG KAU-MING

IPC: C07D491/22

CPC classification number: C07D491/22

Abstract: The key intermediate in any synthesis of Irinotecan is 7-ethyl-10-hydroxy-20(S) camptothecin. A process for the efficient synthesis of this intermediate is demonstrated proceeding through readily availabe 20(S)-camptothecin. Various other tecan compounds may be made by use of corresponding 7-alkyl-10-hydroxy-20(S)-camptothecin intermediates.

Abstract translation: 伊立替康合成中的关键中间体是7-乙基-10-羟基-20（S）喜树碱。 通过容易地得到20（S） - 喜树碱进行有效合成该中间体的方法。 各种其他的tecan化合物可以通过使用相应的7-烷基-10-羟基-20（S） - 喜树碱中间体来制备。

公开(公告)号：EP1430031A4

公开(公告)日：2004-10-13

申请号：EP02751512

申请日：2002-05-20

Applicant: SCINOPHARM TAIWAN LTD

Inventor： TSENG WEI-HONG ,  SCHLOEMER GEORGE ,  CHENG KAU MING ,  CHEN CHIEN WEN ,  CHENG CHIH WEN

IPC: A61K31/55 ,  A61P9/02 ,  A61P9/12 ,  A61P13/12 ,  A61P43/00 ,  C07B53/00 ,  C07B55/00 ,  C07B61/00 ,  C07D223/16 ,  C07D223/12

CPC classification number: C07D223/16

Abstract: The present invention provides an efficient synthetic process for making benazepril and analogues thereof by having an intermediate compound undergo epimerization and kinetic resolution.

公开(公告)号：EP4031533A1

公开(公告)日：2022-07-27

申请号：EP20865568.8

申请日：2020-09-17

Applicant: ScinoPharm Taiwan, Ltd.

Inventor： CHANG, Yung-Hung ,  HSIAO, Tsung-Yu ,  LIAO, Yuan-Xiu ,  TSENG, Hsin-Chang

IPC: C07D239/54 ,  A61K31/513