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41.发明公开PROTEIN AND NUCLEIC ACID DELIVERY VEHICLES, COMPONENTS AND MECHANISMS THEREOF 审中-公开手段蛋白质和核酸供应及其部件和机制，
公开(公告)号：EP2542681A2
公开(公告)日：2013-01-09
申请号：EP11765160.4
申请日：2011-04-08
发明人： RAO, Venigalla
CPC分类号： C12N15/86 , A61K31/7088 , A61K31/711 , A61K47/6901 , A61K48/00 , C07K14/005 , C12N7/00 , C12N15/87 , C12N15/88 , C12N2795/10042 , C12N2795/10122 , C12N2795/10142 , C12N2795/10152
摘要： Complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. During genome packaging in bacteriophages, a powerful molecular motor assembles at the special portal vertex of an empty prohead to initiate packaging. An aspect of the invention relates to the phage T4 packaging machine being highly promiscuous, translocating DNA into finished phage heads as well as into proheads. Single motors can force exogenous DNA into phage heads at the same rate as into proheads and phage heads undergo repeated initiations, packaging multiple DNA molecules into the same head. This shows that the phage DNA packaging machine has unusual conformational plasticity, powering DNA into an apparently passive capsid receptacle, including the highly stable virus shell, until it is full. These features allow for the design of a novel class of nanocapsid delivery vehicles.
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公开(公告)号：EP2129776A1
公开(公告)日：2009-12-09
申请号：EP08731065.2
申请日：2008-02-29
发明人： ALVING, Carl R. , RAO, Venigalla
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K39/385 , A61K2039/55555 , A61K2039/55572 , A61K2039/6075 , C07K14/005 , C07K2319/735 , C12N2740/16122 , C12N2740/16134 , C12N2795/10122
摘要： T4 bacteriophages are bound to substrates such as liposomes using a binder.
摘要翻译： 配体 - 受体粘合剂体系也可以用作T4-脂质体粘合剂。
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公开(公告)号：EP2094356A2
公开(公告)日：2009-09-02
申请号：EP06838452.8
申请日：2006-11-28
发明人： LITOVITZ, Théodore
IPC分类号： A61N2/00
CPC分类号： A61N2/02
摘要： The present invention provides a method and apparatus for delivering an electric field to a body, comprising delivering a polarized magnetic field in a first direction to a body and directed at a desired target within the body, and changing the delivery direction of the magnetic field to a second direction directed at the desired target to induce an electric field across the desired target.
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44.发明公开
公开(公告)号：EP1986743A2
公开(公告)日：2008-11-05
申请号：EP07763559.7
申请日：2007-02-01
发明人： MEHL, Patrick , COHEN, Andrea , LITOVITZ, Theodore
IPC分类号： A61N5/00
CPC分类号： A61N5/10 , A61K47/6901 , A61N2005/1098
摘要： Enhancing the effectiveness of therapeutic ionizing radiation and other treatments of disease in which cells are to be destroyed or modified, by subjecting cells in need thereof to low-dose radiation to increase the sensitivity of the cells to subsequent subjection with a lethal dose of high dose radiation (HDR), a chemotherapeutic agent, or other type of therapeutic treatment.
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公开(公告)号：EP1479035A2
公开(公告)日：2004-11-24
申请号：EP03709232.7
申请日：2003-02-25
发明人： WANG, Yue, Joseph
CPC分类号： G06K9/0014 , G06K9/6232 , G06K9/6242 , G06T7/0012 , G06T2207/30072 , Y10S128/922
摘要： The present invention describes a partial independent component (PICA) technique for blindly separating partially independent and/or gaussian-like sources from mixed observations over an informative index subspace, which allows various applications in independent component imaging. The present invention estimates a demixing matrix using only the independent and/or nongaussian portion of the observations. The present invention also demonstrates the principle of the approach on both controlled cases and real-world problems, and describes many extended applications of such a technique.
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46.发明授权A process for isolation, purification, and recrystallization of lutein from saponified marigold oleoresin and uses thereof 失效一种用于分离，纯化，并从皂化的金盏花含油树脂叶黄素再结晶，而这些用途处理
公开(公告)号：EP0672655B1
公开(公告)日：2000-04-05
申请号：EP95300273.0
申请日：1995-01-17
发明人： Khachik, Frederick
IPC分类号： C07C403/24 , C07B61/00
CPC分类号： C07C403/24 , A23L5/44 , C07C35/21 , C09B61/00 , C09B67/0096
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47.发明公开
公开(公告)号：EP0893103A1
公开(公告)日：1999-01-27
申请号：EP98120291.4
申请日：1992-01-16
发明人： Litovitz, Theodore A
摘要： An arrangement for inhibiting the adverse effect of an ambient time varying field having an electric component of 5 Kv/M or less and/or a magnetic component of 500 µT or less on a living system. To provide protection, at least one of the characteristic parameters of said field to which the living system is exposed is changed within time intervals of less than 10 seconds.
摘要翻译： 一种用于抑制在生物系统上具有5Kv / M以下的电气成分和/或500μT以下的磁性成分的环境时变场的不利影响的装置。 为了提供保护，在小于10秒的时间间隔内改变生物系统所暴露的所述场的特征参数中的至少一个。
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48.发明公开PROTECTION OF LIVING SYSTEMS FROM ADVERSE EFFECTS OF ELECTRIC, MAGNETIC AND ELECTROMAGNETIC FIELDS 失效生命系统的电动副作用，磁场和ELEKTOMAGNETISCHEN保护
公开(公告)号：EP0783278A1
公开(公告)日：1997-07-16
申请号：EP94927971.0
申请日：1994-09-12
CPC分类号： A61B90/04 , A61B2090/0418 , A61B2090/0481
摘要： The embodiments of the inventions disclosed in this application develop a 'protection' electric, magnetic or electromagnetic field or fields which are either superimposed upon an ambient field which is detrimental to the health of living systems, or incorporated into the electrical circuit of the device which is generating the detrimental field. Either arrangement is successful in 'confusing' living cells, and thereby reducing the harmful effects of the otherwise detrimental field.
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