公开(公告)号：EP2443146A1

公开(公告)日：2012-04-25

申请号：EP10790117.5

申请日：2010-06-16

申请人： Indiana University Research And Technology Corporation

发明人： DIMARCHI, Richard, D. ,  SMILEY, David, L. ,  DIMARCHI, Maria ,  CHABENNE, Joseph ,  DAY, Jonathan ,  PATTERSON, James ,  WARD, Brian, P. ,  TAO, Ma

IPC分类号： C07K14/605

CPC分类号： C07K14/605 ,  A61K38/00 ,  A61K38/26

摘要： Glucagon peptides with increased GIP activity are provided, optionally with GLP-I and/or glucagon activity. In some embodiments, C-terminally extended glucagon peptides comprising an amino acid sequence substantially similar to native glucagon are provided herein.

公开(公告)号：EP2214691A1

公开(公告)日：2010-08-11

申请号：EP08845541.5

申请日：2008-10-27

申请人： Indiana University Research and Technology Corporation

发明人： DIMARCHI, Richard, D. ,  YANG, Bin ,  OUYANG, Chenguang

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/605

CPC分类号： C07K14/605 ,  A61K38/00 ,  A61K38/16 ,  A61K38/22 ,  A61K38/26 ,  C07K7/02

摘要： Glucagon analogs are disclosed that exhibit both glucagon antagonist and GLP-1 agonist activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified amino acid sequence of native glucagon, in which the first one to five N-terminal amino acids of native glucagon is deleted and in which the alpha helix is stabilized.