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    Laidlomycin phenylcarbamate
    41.
    发明公开
    Laidlomycin phenylcarbamate 失效
    莱索霉素苯基氨基甲酸酯

    公开(公告)号：EP0153718A3

    公开(公告)日：1986-06-11

    申请号：EP85102001

    申请日：1985-02-22

    申请人： SYNTEX (U.S.A.) INC.

    发明人： Clark, Robin Douglas

    IPC分类号： C07H19/01 ,  C07D493/10 ,  A61K31/70 ,  A23K01/17 ,  C07D311/00 ,  C07D307/00

    CPC分类号： C07H19/01 ,  A23K20/195

    摘要： A compound represented by the formula
    wherein R 1 is an alkali metal cation or hydrogen and which useful for increasing the feed efficiency of ruminants and for treating coccidiosis in domestic animals, especially chickens.

    摘要翻译： 由下式表示的化合物：其中R1是碱金属阳离子或氢，并且其可用于提高反刍动物的饲料效率和用于治疗家畜（特别是鸡）的球虫病。

    SUBSTITUTED SPIROKETAL DERIVATIVE AND USE THEREOF AS DRUG FOR TREATING DIABETES
    50.
    发明公开
    SUBSTITUTED SPIROKETAL DERIVATIVE AND USE THEREOF AS DRUG FOR TREATING DIABETES 审中-公开
    替代品SPIROKETALDERIVAT UND DESSEN VERWENDUNG ALS ARZNEIMITTEL ZUR BEHANDLUNG VON糖尿病

    公开(公告)号：EP2048153A1

    公开(公告)日：2009-04-15

    申请号：EP07791500.7

    申请日：2007-07-27

    申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

    发明人： SATO, Tsutomu ,  HONDA, Kiyofumi ,  KAWAI, Takahiro ,  AHN, Koo Hyeon

    IPC分类号： C07H19/01 ,  A61K31/7048 ,  A61P3/04 ,  A61P3/10 ,  A61P43/00

    CPC分类号： C07H19/01

    摘要： The present invention provides a compound represented by Formula (II):

    wherein R 1 is a chlorine atom, a fluorine atom, a methyl group or an ethynyl group;
    Ar is a group represented by the following Formula (a), Formula (b), Formula (c) or Formula (d):

    wherein R 2 is a C 1-6 alkyl group which may be substituted with one or more halogen atoms, a C 1-6 alkoxy group which may be substituted with one or more halogen atoms, a C 1-3 alkylthio group, a halogen atom, a C 1-3 alkylcarbonyl group or a C 2-5 alkynyl group which may be substituted with -OR 4 ;
    R 3 is a hydrogen atom or a C 1-3 alkyl group;
    R 4 is a hydrogen atom or a C 1-3 alkyl group;
    provided that Ar is a group represented by Formula (a) when R 1 is a fluorine atom, methyl group or an ethynyl group, and
    that R 2 is methoxy group, an ethoxy group, an isopropyl group, a propyl group, a trifluoromethyl group, a trifluoromethoxy group, 2-fluoroethyl group or 1-propynyl group when R 1 is a methyl group or a pharmaceutically acceptable salt or a solvate thereof and a pharmaceutical agent, a pharmaceutical composition and so on comprising the compound.

    摘要翻译： 本发明提供由式（II）表示的化合物：其中R 1是氯原子，氟原子，甲基或乙炔基; Ar是由下式（a），式（b），式（c）或式（d）表示的基团：其中R 2是可以被一个或多个卤素原子取代的C 1-6烷基， 可以被一个或多个卤素原子取代的C 1-6烷氧基，C 1-3烷硫基，卤素原子，C 1-3烷基羰基或C 2-5炔基，其可以被 -OR 4; R 3是氢原子或C 1-3烷基; R 4是氢原子或C 1-3烷基; 条件是当R 1为氟原子，甲基或乙炔基时，Ar为式（a）表示的基团，R 2为甲氧基，乙氧基，异丙基，丙基，三氟甲基 当R 1是甲基时，三氟甲氧基，2-氟乙基或1-丙炔基，或其药学上可接受的盐或溶剂合物和药物，药物组合物等。