公开(公告)号：EP2601178A2

公开(公告)日：2013-06-12

申请号：EP11814205.8

申请日：2011-08-01

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  RAJI REDDY, Rapolu ,  MURALIDHARA REDDY, Dasari ,  SRINIVASA RAO, Thungathurthy ,  VAMSI KRISHNA, Bandi

IPC分类号： C07D239/72

CPC分类号： C07D405/10 ,  C07D405/04

摘要： The present invention provides novel dioxalate salt of lapatinib, process for its preparation and pharmaceutical compositions comprising it. The present invention also provides novel monobesylate salt of lapatinib, process for its preparation and pharmaceutical compositions comprising it. The present invention further provides a process for the preparation of monohydrate form of lapatinib ditosylate. The present invention further provides a process for the preparation of anhydrous form of lapatinib ditosylate.

摘要翻译： 本发明提供了拉帕替尼的新型二恶烷酸盐，其制备方法和包含其的药物组合物。 本发明还提供了新颖的拉帕替尼的单伯酯盐，其制备方法和包含它的药物组合物。 本发明进一步提供了制备拉帕替尼二磺酸一水合物形式的方法。 本发明还提供了制备无水形式的拉帕替尼二甲磺酸盐的方法。

公开(公告)号：EP2593422A1

公开(公告)日：2013-05-22

申请号：EP10854669.8

申请日：2010-07-16

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY , Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  RAJI REDDY, Rapolu ,  MUKUNDA REDDY, Jambula ,  VAMSI KRISHNA, Bandi

IPC分类号： C07C211/00

摘要： 3-[3-(Trifluoromethyl)phenyl]propionaldehyde is a key intermediate for the preparation of cinacalcet hydrochloride. The present invention provides a novel process for the preparation of 3-[3-(trifluoromethyl)phenyl]propionaldehyde. The present invention also provides an improved process for preparation of cinacalcet hydrochloride in high yields. The present invention further provides a process for purification of cinacalcet hydrochloride.

摘要翻译： 3- [3-（三氟甲基）苯基]丙醛是制备盐酸西那卡塞的关键中间体。 本发明提供了制备3- [3-（三氟甲基）苯基]丙醛的新方法。 本发明还提供了高收率制备盐酸西那卡塞的改进方法。 本发明进一步提供了一种纯化盐酸西那卡塞的方法。

公开(公告)号：EP2585441A1

公开(公告)日：2013-05-01

申请号：EP10854025.3

申请日：2010-06-28

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  RAJI REDDY, Rapolu ,  RAMAKRISHNA REDDY, Matta ,  VAMSI KRISHNA, Bandi

IPC分类号： C07D257/04

CPC分类号： C07D405/14

摘要： The present invention provides a process for the preparation of substantially pure trityl olmesartan medoxomil. The present invention also provides a process for purification of trityl olmesartan medoxomil. The present invention further provides a process for purification of olmesartan medoxomil.

公开(公告)号：EP2575465A1

公开(公告)日：2013-04-10

申请号：EP10852079.2

申请日：2010-05-25

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  RAJI REDDY, Rapolu ,  SUBASH CHANDER REDDY, Kesireddy ,  VAMSI KRISHNA, Bandi

IPC分类号： A01N43/54 ,  A61K31/505 ,  C07D413/12

CPC分类号： C07D413/12 ,  A61K31/513

摘要： The present invention provides novel salts of raltegravir, processes for their preparation and pharmaceutical compositions comprising them. The present invention also provides crystalline sodium salt of raltegravir, process for its preparation and pharmaceutical compositions comprising it. The present invention further provides a process for the preparation of amorphous sodium salt of raltegravir. The present invention further provides a process for the preparation of raltegravir potassium crystalline form H1.

摘要翻译： 本发明提供了raltegravir的新盐，其制备方法和包含它们的药物组合物。 本发明还提供了拉替拉韦的结晶钠盐，其制备方法和包含它的药物组合物。 本发明进一步提供了制备raltegravir的无定形钠盐的方法。 本发明进一步提供了制备raltegravir钾晶型H1的方法。