公开(公告)号：EP1968559A2

公开(公告)日：2008-09-17

申请号：EP06844984.2

申请日：2006-12-07

申请人： Metaproteomics, LLC

发明人： TRIPP, Matthew, L. ,  BABISH, John, G. ,  BLAND, Jeff ,  HALL, Amy, Jennae ,  KONDA, Veera ,  PACIORETTY, Linda

IPC分类号： A61K31/01 ,  A61K36/185 ,  A61K36/235 ,  A61K36/282 ,  A61K36/31 ,  A61K36/48 ,  A61K36/68 ,  A61K36/73 ,  A61P5/48

CPC分类号： A61K36/282 ,  A61K31/015 ,  A61K31/12 ,  A61K31/353 ,  A61K36/185 ,  A61K36/23 ,  A61K36/235 ,  A61K36/31 ,  A61K36/48 ,  A61K36/73 ,  A61K36/80 ,  A61K2300/00

摘要： Disclosed are botanically based compositions and methods useful for the treatment of metabolic syndrome and diabetes type 2. Compositions, kits, and methods are additionally disclosed for means to augment the activity of identified glucose and insulin regulating drugs.

公开(公告)号：EP1718313A1

公开(公告)日：2006-11-08

申请号：EP05723895.8

申请日：2005-02-26

申请人： Metaproteomics, LLC

发明人： BABISH, John, G. ,  TRIPP, Matthew, L. ,  BLAND, Jeffrey, S.

IPC分类号： A61K31/557 ,  A61K31/12 ,  A61K36/18

CPC分类号： A61K36/185 ,  A61K31/12 ,  A61K31/19 ,  A61K31/557 ,  A61K36/12 ,  A61K2300/00

摘要： The invention provides a composition comprising a reduced isoalpha acid (RIAA) and isoalpha acid (IAA) isolated from hops, wherein the RIAA and IAA are in a ratio of about 3:1 to about 1:10. The invention also provides a method of reducing inflammation by administering a composition comprising a reduced isoalpha acid (RIAA) and isoalpha acid (IAA) isolated from hops, wherein the RIAA and IAA are in a ratio of, about 3:1 to about 1:10.

公开(公告)号：EP1446136A2

公开(公告)日：2004-08-18

申请号：EP02784313.5

申请日：2002-10-25

申请人： Metaproteomics, LLC

发明人： BABISH, John, G. ,  HOWELL, Terrence ,  PACIORETTY, Linda

IPC分类号： A61K35/78

CPC分类号： A61K45/06 ,  A61K31/12 ,  A61K31/122 ,  A61K31/351 ,  A61K36/185 ,  A61K36/9066 ,  A61K2300/00

摘要： A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a curcuminoid species and an effective amount of a second component selected from the group consisting of an alpha-acid species or a beta-acid species or derivatives thereof. The composition provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.

公开(公告)号：EP1411959A1

公开(公告)日：2004-04-28

申请号：EP02748188.6

申请日：2002-07-17

申请人： Metaproteomics, LLC

发明人： BABISH, John, G. ,  HOWELL, Terrence ,  PACIORETTY, Linda

IPC分类号： A61K35/78

CPC分类号： A61K31/365 ,  A61K31/047 ,  A61K31/075 ,  A61K31/12 ,  A61K31/19 ,  A61K31/366 ,  A61K31/56 ,  A61K31/704 ,  A61K36/00 ,  A61K36/9066 ,  A61K45/06 ,  A61K2300/00

摘要： Compositions comprising an effective amount of a curcuminoid species and an effective amount of a diterpene lactone species, a triterpene species or derivatives thereof that have a synergistic effect on specific inhibition of inducible COX-2 activity and have minimal effect on COX-1 activity are disclosed. Methods of using the compositions for providing synergistic anti-inflammatory effects are also disclosed.

公开(公告)号：EP2787988A2

公开(公告)日：2014-10-15

申请号：EP12855948.1

申请日：2012-12-07

申请人： Metaproteomics, LLC

发明人： TRIPP, Matthew, L. ,  LERMAN, Robert, H.

IPC分类号： A61K31/232

CPC分类号： A61K35/616 ,  A61K31/05 ,  A61K31/09 ,  A61K31/122 ,  A61K31/185 ,  A61K31/195 ,  A61K31/232 ,  A61K31/353 ,  A61K31/355 ,  A61K31/385 ,  A61K31/455 ,  A61K31/56 ,  A61K35/60 ,  A61K35/612 ,  A61K35/655 ,  A61K36/02 ,  A61K2300/00

摘要： Disclosed are compositions and methods comprising supplemented oils for improving health, reducing cardiovascular risk factors, or treating certain conditions.

公开(公告)号：EP2364083A4

公开(公告)日：2012-10-31

申请号：EP09832519

申请日：2009-12-10

申请人： METAPROTEOMICS LLC

发明人： CARROLL BRIAN J ,  DAHLBERG CLINTON J ,  TRAUBE JAMES S

IPC分类号： C07C45/80 ,  C07C49/707 ,  C07C49/743

CPC分类号： C07C45/80 ,  C07C2601/10 ,  C07C49/743

公开(公告)号：EP2348868A1

公开(公告)日：2011-08-03

申请号：EP09822521.2

申请日：2009-10-20

申请人： Metaproteomics, LLC

发明人： BABISH, John, G. ,  PACIORETTY, Linda, M. ,  TRIPP, Matthew, L. ,  BLAND, Jeffrey, S.

IPC分类号： A01N65/00 ,  A61K31/415

CPC分类号： A61K31/05 ,  A61K36/00 ,  A61K2300/00

摘要： Disclosed are methods, compounds, and compositions comprising botanically based drugs, medical foods, and dietary supplements for the prevention and treatment of metabolic disorders, in particular obesity, weight gain, insulin resistance syndromes, diabetes, fasting hyperlipidemia and osteoarthritis. More specifically, the invention relates to pharmaceutical therapeutic methods and compositions utilizing phytochemicals, natural plant extracts and combinations to modify adipocyte physiology to enhance thermogenesis and modify cytokine secretion.

公开(公告)号：EP2152684A4

公开(公告)日：2011-05-18

申请号：EP08729724

申请日：2008-02-13

申请人： METAPROTEOMICS LLC

发明人： TRIPP MATTHEW L ,  KONDA VEERA ,  HALL AMY ,  DESAI ANU ,  BLAND JEFFREY S ,  MINICH DEANNA

IPC分类号： A61K31/121 ,  A61K31/00 ,  A61K31/122 ,  A61K31/365 ,  A61K33/30 ,  A61P39/02 ,  A61P39/04 ,  A61P43/00

CPC分类号： C07D309/24 ,  A61K31/00 ,  A61K31/121 ,  A61K31/122 ,  A61K31/365 ,  A61K33/30 ,  C07C49/255 ,  C07C49/707 ,  C07C49/743 ,  A61K2300/00

公开(公告)号：EP2229178A4

公开(公告)日：2011-03-09

申请号：EP08859091

申请日：2008-12-10

申请人： METAPROTEOMICS LLC

发明人： TRIPP MATTHEW L ,  BABISH JOHN G ,  BLAND JEFFREY S ,  KONDA VEERA ,  DESAI ANU ,  DARLAND GARY ,  CARROLL BRIAN ,  TRAUB JAMES ,  PACIORETTY LINDA M ,  EMMA DENNIS A

IPC分类号： A61K38/00 ,  A61K31/12 ,  A61K45/06 ,  A61P35/00

CPC分类号： A61K31/12 ,  A61K45/06 ,  A61K2300/00

公开(公告)号：EP2277526A1

公开(公告)日：2011-01-26

申请号：EP10013109.3

申请日：2002-06-20

申请人： Metaproteomics, LLC

发明人： Babish, John, G. ,  Howell, Terrence, M.

IPC分类号： A61K36/185

CPC分类号： A61K31/00 ,  A23L33/10 ,  A61K31/12 ,  A61K45/06 ,  A61K2300/00

摘要： A novel composition is provided that serves to specifically inhibit the COX-2 mediated inflammatory response in animals. The composition comprises a pharmaceutical grade preparation of an effective amount of tetrahydroisohumulone with an effective amount of at least one component selected from the group consisting of humulone, cohumulone, isohumulone, isoprehumulone, hulupone, adhumulone, xanthohumol A and xanthohumol B, lupulone, colupulone, adlupulone, and hexahydrocolupulone.

摘要翻译： 提供了一种用于特异性抑制COX-2介导的动物炎症反应的新型组合物。 该组合物包含有效量的四氢异葎草酮的药物级制剂，其有效量为至少一种选自葎草酮，共聚葎草酮，异葎草酮，异葎草酮，胡萝卜素，异葎草酮，黄假单胞菌素A和黄单胞菌素B，布洛芬， adlupulone和六氢异丙龙。