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395 条记录 (耗时 0.013 秒)

    TREATING URINARY INCONTINENCE USING (S)-OXYBUTYNIN AND (S)-DESETHYLOXYBUTYNIN
    51.
    发明公开
    TREATING URINARY INCONTINENCE USING (S)-OXYBUTYNIN AND (S)-DESETHYLOXYBUTYNIN 失效
    USE（S）和奥昔布宁（S）-desethyloxybutynin用于治疗尿失禁

    公开(公告)号：EP0914113A1

    公开(公告)日：1999-05-12

    申请号：EP97931531.0

    申请日：1997-06-27

    申请人： SEPRACOR, INC.

    发明人： ABERG, Gunnar ,  McCULLOUGH, John, R.

    IPC分类号： A61K9 ,  A61K31 ,  A61P13

    CPC分类号： A61K31/216

    摘要： A method for treating urinary incontinence while avoiding concomitant liability of adverse effects associated with racemic oxybutynin is disclosed. The method comprises administering from 100 mg to 1 000 mg/day of (S)-oxybutynin, (S)-desethyloxybutynin or a pharmaceutically acceptable salt thereof, substantially free of the corresponding R enantiomer. Pharmaceutical compositions in the form of tablets, soft elastic gelatin capsules and transdermal devices comprising an acceptable carrier and up to 500 mg of (S)-oxybutynin or (S)-desethyloxybutynin are also disclosed.

    METHODS AND COMPOSITIONS FOR TREATING URINARY INCONTINENCE USING ENANTIOMERICALLY ENRICHED (S,R)-GLYCOPYRROLATE
    52.
    发明公开
    METHODS AND COMPOSITIONS FOR TREATING URINARY INCONTINENCE USING ENANTIOMERICALLY ENRICHED (S,R)-GLYCOPYRROLATE 失效
    使用富含赋形剂的（S，R） - 甘油基丙酸酯治疗尿失禁的方法和组合物

    公开(公告)号：EP0909163A1

    公开(公告)日：1999-04-21

    申请号：EP97931548.0

    申请日：1997-06-27

    申请人： SEPRACOR, INC.

    发明人： FABIANO, Vincent, L. ,  McCULLOUGH, John, R.

    IPC分类号： A61K31 ,  C07D207

    CPC分类号： C07D207/12 ,  A61K31/40 ,  C07B2200/07

    摘要： A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S,R)-glycopyrrolate. The method comprises administering a therapeutically effective amount of enantiomerically enriched (S,R)-glycopyrrolate, or a pharmaceutically acceptable salt thereof, substantially free of the (R,S)-glycopyrrolate enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S,R)-glycopyrrolate, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.

    摘要翻译： 使用对映体富集的（S，R） - 格隆溴铵治疗尿失禁（例如由膀胱逼尿肌不稳定导致的失禁）的方法。 该方法包括给予治疗有效量的基本上不含（R，S） - 格隆溴铵对映体的对映体富集的（S，R） - 格隆溴铵或其药学上可接受的盐。 还公开了用于治疗尿失禁的药物组合物，其包含对映体富集的（S，R） - 格隆溴铵或其药学上可接受的盐和可接受的载体。

    ANTINEOPLASTIC METHODS AND COMPOSITIONS EMPLOYING (+)-FOTEMUSTINE
    53.
    发明公开
    ANTINEOPLASTIC METHODS AND COMPOSITIONS EMPLOYING (+)-FOTEMUSTINE 失效
    抗肿瘤的方法和手段使用（+） - 福莫司汀

    公开(公告)号：EP0868189A1

    公开(公告)日：1998-10-07

    申请号：EP96940517.0

    申请日：1996-11-19

    申请人： SEPRACOR, INC.

    发明人： GRAY, Nancy, M.

    IPC分类号： A61K31 ,  A61P35

    CPC分类号： A61K31/662

    摘要： Methods and compositions are disclosed utilizing optically pure (+)-fotemustine for the treatment of various malignancies, while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of fotemustine.

    METHODS AND COMPOSITIONS FOR TREATING ANDROGEN-DEPENDENT DISEASES USING OPTICALLY PURE R-(-)-CASODEX
    59.
    发明公开
    METHODS AND COMPOSITIONS FOR TREATING ANDROGEN-DEPENDENT DISEASES USING OPTICALLY PURE R-(-)-CASODEX 失效
    方法和组合物用于治疗雄激素依赖性疾病VERWENDDUNG光学纯的R - （ - ）CASODEX

    公开(公告)号：EP0748220A1

    公开(公告)日：1996-12-18

    申请号：EP95908626.0

    申请日：1995-01-20

    申请人： SEPRACOR, INC.

    发明人： GRAY, Nancy, M.

    IPC分类号： A61K9 ,  A61K31 ,  A61P35 ,  C07C317

    CPC分类号： A61K31/277 ,  A61K31/275 ,  Y10S514/859

    摘要： Methods and compositions are disclosed utilizing optically pure R-(-)-casodex for the treatment of androgen-dependent prostate cancer, while substantially reducing the concomitant liability of adverse effects associated with the central antiandrogen activity of the racemic mixture of casodex. R-(-)-casodex is a peripherally selective antiandrogen and is therefore useful in the treatment of other conditions supported by androgen or caused by elevated androgen levels. Such conditions include benign prostatic hypertrophy or hyperplasia, acne and hirsutism.