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公开(公告)号：EP1595532A3
公开(公告)日：2007-05-30
申请号：EP05016415.1
申请日：1995-08-31
CPC分类号： A61K9/1629 , A61J1/201 , A61J1/2013 , A61J1/2086 , A61J1/2089 , A61J1/2096 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/19 , A61K9/2018 , A61K9/70 , A61K38/09 , A61K38/23 , A61K38/25 , A61K38/29 , A61K38/31 , A61K47/26 , A61M5/14244 , A61M5/14248 , A61M5/31505 , A61M5/31531 , A61M31/002 , A61M37/0069
摘要： The invention features a solid, non-particulate, sustained-release pharmaceutical composition for parenteral administration to a patient. The composition consists essentially of (1) a soluble, gelable peptide salt, and (2) up to 30 percent, by weight, of a pharmaceutically acceptable, monomeric, soluble carrier, compounded into a solid cylindrical form, wherein the solid composition automatically forms a gel after interaction with the patient's bodily fluids, the gel releasing the peptide continuously within the patient over an extended period of at least three days.
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公开(公告)号：EP1015439B1
公开(公告)日：2007-04-11
申请号：EP97926849.7
申请日：1997-05-29
发明人： KIM, Sun, H.
IPC分类号： C07K5/08 , C07D285/38 , A61K31/33 , C07C323/60 , C07D339/00 , C07D513/04
CPC分类号： C07D513/04 , A61K38/00 , C07C323/60 , C07D217/26 , C07D241/04 , C07D285/36 , C07D285/38 , C07D339/00 , C07D417/06 , C07D417/14 , C07D513/14 , C07K5/0606 , C07K5/081
摘要： A family of compounds capable of inhibiting the activity of prenyl transferases. The compounds are covered by either of two formulas (I, II). Each of the R groups is defined in the disclosure.
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公开(公告)号：EP1348444B1
公开(公告)日：2006-04-12
申请号：EP03076829.5
申请日：2000-08-16
IPC分类号： A61K47/48
CPC分类号： A61K47/62 , A61K47/593
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64.发明公开Method of inhibiting fibrosis with a somatostatin agonist 失效Verfahren zur Hemmung der Fibrose mittels eines Somatostatin-Agonisten
公开(公告)号：EP1574219A2
公开(公告)日：2005-09-14
申请号：EP05076124.6
申请日：1997-08-27
摘要： The present invention relates to a method of inhibiting fibrosis in a patient. The method comprises administering a therapeutically effective amount of a somatostatin, a somatostatin agonist or a pharmaceutically acceptable salt thereof to said patient.
摘要翻译： 本发明涉及一种抑制患者纤维化的方法。 该方法包括向所述患者施用治疗有效量的生长抑素，生长抑素激动剂或其药学上可接受的盐。
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公开(公告)号：EP0904274B1
公开(公告)日：2005-05-25
申请号：EP97907717.9
申请日：1997-02-14
IPC分类号： C07D487/04 , C07D277/20 , C07D277/28 , C07D277/38 , C07D263/30 , C07D263/34 , C07D233/54 , A61K31/495 , A61K31/425 , A61K31/42 , A61K31/415
CPC分类号： C07D233/64 , C07D277/28 , C07D277/56 , C07D487/04
摘要： A family of compounds capable of inhibiting the activity of farnesyl transferase.
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66.发明公开
公开(公告)号：EP1498150A1
公开(公告)日：2005-01-19
申请号：EP04019495.3
申请日：1995-08-31
IPC分类号： A61M5/178
CPC分类号： A61K9/0024 , A61J1/201 , A61K9/0019 , A61K9/06 , A61K9/2018 , A61K9/70 , A61K38/09 , A61K38/25 , A61K38/28 , A61K38/31 , A61K47/26 , A61M5/14248 , A61M5/1452 , A61M5/31531 , A61M5/31575 , A61M5/31595 , A61M37/0069 , A61M2005/14268
摘要： This invention relates to the parenteral administration of solid drug compositions. In particular, this invention relates to a syringe-like device for delivering solid drug cylinders including a syringe barrel, a needle, and a microplunger and piston assembly, wherein said microplunger pushes said solid drug cylinder out of said needle and into a patient and said piston pushes on said microplunger.
摘要翻译： 本发明涉及固体药物组合物的肠胃外给药。 特别地，本发明涉及一种用于输送固体药物瓶的注射器状装置，其包括注射器筒，针和微型活塞和活塞组件，其中所述微型活塞将所述固体药物药筒推出所述针头并进入患者体内，并且所述 活塞推动所述微型活塞。
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公开(公告)号：EP0954346B1
公开(公告)日：2004-11-03
申请号：EP97953913.7
申请日：1997-12-23
IPC分类号： A61M5/32
CPC分类号： A61M5/3257 , A61M2005/3265
摘要： The invention features an injection device for injecting a liquid or semi-solid composition into a subject.
摘要翻译： 本发明的特征在于用于将液体或半固体组合物注射到受试者体内的注射装置。
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公开(公告)号：EP1086086B1
公开(公告)日：2004-10-13
申请号：EP99927323.8
申请日：1999-06-08
发明人： THURIEAU, Christophe, Alain , POITOUT, Lydie, Francine , GALCERA, Marie-Odile , GORDON, Thomas, D. , MORGAN, Barry , MOINET, Christophe, Philippe
IPC分类号： C07D233/00
CPC分类号： C07D233/64 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/14
摘要： The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.
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公开(公告)号：EP1382607A3
公开(公告)日：2004-06-30
申请号：EP03078315.3
申请日：1999-12-30
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/551 , A61K31/5517 , A61P35/00 , C07D513/14 , C07D519/00
CPC分类号： C07D487/04 , C07D513/14
摘要： A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR 11 ) n3 (CH 2 ) n4 Z(CH 2 ) n5 where Z is O, N(R 12 ), S, or a bond; Y is CO, CH 2 , CS, or a bond; R 1 is or N(R 24 R 23 ); and the remaining substituents are as defined in the disclosure.
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公开(公告)号：EP1405861A2
公开(公告)日：2004-04-07
申请号：EP03077383.2
申请日：1996-07-03
发明人： Dong, Zheng Xin
IPC分类号： C07K14/635 , A61K38/29
CPC分类号： C07K14/635 , A61K38/00
摘要： Peptide variants of fragment (1-34) of parathyroid hormone, in which at least one of the amino acid residues at positions 7, 11, 23, 24, 27, 28 and 31 is cyclohexylalanine, or at least one of the amino acid residues at positions 3, 16, 17, 18, 19 and 34 is α-aminoisobutyric acid; or, alternatively, at least the amino acid residue at position 1 is α,β-diaminopropionic acid, the amino acid residue at position 27 is homoarginine, or the amino acid residue at position 31 is norleucine.
摘要翻译： 甲状旁腺激素片段（1-34）的肽变体，其中7,11,23,24,27,28和31位的至少一个氨基酸残基是环己基丙氨酸，或至少一个氨基酸残基 位置3,16,17,18,19和34是α-氨基异丁酸; 或者，至少第1位的氨基酸残基是α，β-二氨基丙酸，27位的氨基酸残基是高精氨酸，或者31位的氨基酸残基是正亮氨酸。
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