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公开(公告)号：EP1287488B1
公开(公告)日：2017-10-04
申请号：EP01926261.7
申请日：2001-04-10
申请人： Pacific Edge Limited
IPC分类号： G06N3/04
CPC分类号： G06N3/0436
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公开(公告)号：EP2434023B1
公开(公告)日：2015-02-25
申请号：EP11188990.3
申请日：2005-07-22
申请人： Pacific Edge Limited
IPC分类号： C12Q1/68 , G01N33/574 , C07K14/47
CPC分类号： C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57407 , G01N33/57488 , G01N2800/52
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公开(公告)号：EP2436779A1
公开(公告)日：2012-04-04
申请号：EP11188995.2
申请日：2005-07-22
申请人： Pacific Edge Limited
IPC分类号： C12Q1/68 , G01N33/574 , C07K14/47
CPC分类号： C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57407 , G01N33/57488 , G01N2800/52
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including bladder tumors. Members of the BTM or UBTM family can be highly and consistently accumulated in bladder tumor tissue and other tumor tissue, and/or can be accumulated in urine of patients, and thus are markers for bladder and other types of cancer. In certain embodiments, BTMs or UBTMs can accumulate in the urine, and detection of UBTM family members can be an effective diagnostic approach. In some embodiments, quantitative PCR methods have advantages over microarray methods. In other embodiments, detection and quantification of a plurality of BTMs or UBTMs can increase the sensitivity and specificity of detection of bladder cancer, and therefore provides methods for determining the stage and type of bladder cancer. Kits provide easy, convenient ways for carrying out the methods of this invention.
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公开(公告)号：EP2325338A3
公开(公告)日：2011-10-12
申请号：EP10185010.5
申请日：2004-07-16
申请人： Pacific Edge Limited
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N33/57446
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family, in particular the GTM gene known as serine or cysteine proteinase inhibitor clade H ("SERPINH1"), can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and/or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.
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公开(公告)号：EP2325338A2
公开(公告)日：2011-05-25
申请号：EP10185010.5
申请日：2004-07-16
申请人： Pacific Edge Limited
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N33/57446
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family, in particular the GTM gene known as serine or cysteine proteinase inhibitor clade H ("SERPINH1"), can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and/or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.
摘要翻译： 肿瘤的早期检测是患有肿瘤的患者（包括胃肿瘤）存活的主要决定因素。 GTM基因家族的成员，特别是称为丝氨酸或半胱氨酸蛋白酶抑制剂进化枝H（“SERPINH1”）的GTM基因可以在胃肿瘤组织和其他肿瘤组织中过度表达，因此可以用作胃的标志物 和其他类型的癌症。 GTM蛋白可以从癌细胞释放，并且可以在血清和/或其他流体中达到足够高的浓度以允许其检测。 因此，用于检测和量化GTM的方法和检测试剂盒可以提供诊断胃癌的有价值的工具。
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公开(公告)号：EP2444505B1
公开(公告)日：2016-09-07
申请号：EP11188984.6
申请日：2005-07-22
申请人： Pacific Edge Limited
IPC分类号： C12Q1/68 , G01N33/574 , C07K14/47
CPC分类号： C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57407 , G01N33/57488 , G01N2800/52
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公开(公告)号：EP2434024B1
公开(公告)日：2016-09-07
申请号：EP11188998.6
申请日：2005-07-22
申请人： Pacific Edge Limited
IPC分类号： C12Q1/68 , G01N33/574 , C07K14/47
CPC分类号： C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57407 , G01N33/57488 , G01N2800/52
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公开(公告)号：EP2305833B1
公开(公告)日：2014-04-16
申请号：EP10185594.8
申请日：2004-07-16
申请人： Pacific Edge Limited
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N33/57446
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family, in particular the GTM gene known as serine or cysteine proteinase inhibitor clade H ("SERPINH1"), can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and/or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.
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公开(公告)号：EP2434024A1
公开(公告)日：2012-03-28
申请号：EP11188998.6
申请日：2005-07-22
申请人： Pacific Edge Limited
IPC分类号： C12Q1/68 , G01N33/574 , C07K14/47
CPC分类号： C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57407 , G01N33/57488 , G01N2800/52
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including bladder tumors. Members of the BTM or UBTM family can be highly and consistently accumulated in bladder tumor tissue and other tumor tissue, and/or can be accumulated in urine of patients, and thus are markers for bladder and other types of cancer. In certain embodiments, BTMs or UBTMs can accumulate in the urine, and detection of UBTM family members can be an effective diagnostic approach. In some embodiments, quantitative PCR methods have advantages over microarray methods. In other embodiments, detection and quantification of a plurality of BTMs or UBTMs can increase the sensitivity and specificity of detection of bladder cancer, and therefore provides methods for determining the stage and type of bladder cancer. Kits provide easy, convenient ways for carrying out the methods of this invention.
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公开(公告)号：EP2434023A1
公开(公告)日：2012-03-28
申请号：EP11188990.3
申请日：2005-07-22
申请人： Pacific Edge Limited
IPC分类号： C12Q1/68 , G01N33/574 , C07K14/47
CPC分类号： C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57407 , G01N33/57488 , G01N2800/52
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including bladder tumors. Members of the BTM or UBTM family can be highly and consistently accumulated in bladder tumor tissue and other tumor tissue, and/or can be accumulated in urine of patients, and thus are markers for bladder and other types of cancer. In certain embodiments, BTMs or UBTMs can accumulate in the urine, and detection of UBTM family members can be an effective diagnostic approach. In some embodiments, quantitative PCR methods have advantages over microarray methods. In other embodiments, detection and quantification of a plurality of BTMs or UBTMs can increase the sensitivity and specificity of detection of bladder cancer, and therefore provides methods for determining the stage and type of bladder cancer. Kits provide easy, convenient ways for carrying out the methods of this invention.
摘要翻译： 早期检测肿瘤是患有肿瘤的患者（包括膀胱肿瘤）的主要决定因素。 BTM或UBTM家族的成员可以高度一致地积聚在膀胱肿瘤组织和其他肿瘤组织中，和/或可以积聚在患者的尿液中，因此是膀胱和其他类型癌症的标志物。 在某些实施方案中，BTM或UBTM可以积聚在尿液中，并且UBTM家族成员的检测可以是有效的诊断方法。 在一些实施方案中，定量PCR方法优于微阵列方法。 在其它实施方案中，多个BTM或UBTM的检测和定量可以增加膀胱癌检测的灵敏度和特异性，因此提供了确定膀胱癌的阶段和类型的方法。 套件提供方便实施本发明方法的方便。
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