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公开(公告)号：EP4400495A1
公开(公告)日：2024-07-17
申请号：EP24151077.5
申请日：2024-01-10
申请人： Richter Gedeon Nyrt.
IPC分类号： C07D295/155 , A61P25/18
CPC分类号： C07D295/155 , A61P25/18
摘要： The present disclosure provides for compounds of Formula (I):
wherein R1 has any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions including schizophrenia. Also provided are pharmaceutical compositions comprising compounds of Formula (I).-
2.发明授权
公开(公告)号：EP3976598B1
公开(公告)日：2024-03-27
申请号：EP20730747.1
申请日：2020-05-29
发明人： SEBÕK, Ferenc , MEISZTERICS, Anikó , DEMETER, Ádám
IPC分类号： C07D401/12 , A61K31/454 , A61P25/00
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公开(公告)号：EP3481811B1
公开(公告)日：2022-05-25
申请号：EP17739701.5
申请日：2017-07-07
发明人： NEU, József , GARADNAY, Sándor , SZABÓ, Tamás
IPC分类号： C07D295/06 , C07C275/26
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公开(公告)号：EP3475288B1
公开(公告)日：2021-11-03
申请号：EP17739322.0
申请日：2017-06-22
发明人： NEU, József , SZABÓ, Tamás , GARADNAY, Sándor
IPC分类号： C07D495/04
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公开(公告)号：EP3596080A1
公开(公告)日：2020-01-22
申请号：EP18713016.6
申请日：2018-03-12
申请人： Richter Gedeon Nyrt.
发明人： BORZA, István , ROMÁN, Viktor , ÉLES, János , HADADY, Zsuzsa
IPC分类号： C07D487/04 , A61K31/519 , A61P19/00 , A61P25/00
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7.发明公开
公开(公告)号：EP3596048A1
公开(公告)日：2020-01-22
申请号：EP18713017.4
申请日：2018-03-12
申请人： Richter Gedeon Nyrt.
发明人： FAIGL, Ferenc , MÁTRAVÖLGYI, Béla , MIZSÁK, Ágnes
IPC分类号： C07D211/60
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公开(公告)号：EP3212667B1
公开(公告)日：2018-09-19
申请号：EP15808356.8
申请日：2015-10-28
申请人： Richter Gedeon Nyrt.
IPC分类号： C07K16/24 , A61K39/395 , A61K47/10 , A61K47/18 , A61K47/00 , A61K39/00 , A61K9/00 , A61K47/26
CPC分类号： A61K39/39591 , A61K9/0019 , A61K31/519 , A61K47/10 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/24 , C07K16/241 , C07K2317/21 , C07K2317/76 , C07K2317/94 , A61K2300/00
摘要： Provided are improved storage-stable liquid pharmaceutical antibody formulations. In particular, liquid aqueous pharmaceutical formulations of Adalimumab based on alternative buffer systems to citrate/phosphate and pharmaceutical containers like auto-injection devices containing the same are described.
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公开(公告)号：EP2964613B1
公开(公告)日：2018-07-18
申请号：EP14712780.7
申请日：2014-03-06
申请人： Richter Gedeon Nyrt.
发明人： BARTÁNÉ SZALAI, Gizella , WÁGNER, Gábor András , KISS, Béla , SCHMIDT, Éva , BALÁZS, Ottília , NAGY, Noémi
IPC分类号： C07D211/44 , C07D401/12 , A61K31/4465 , A61K31/454 , A61P25/28
CPC分类号： C07D211/46 , A61K9/0019 , A61K9/0095 , A61K9/02 , A61K9/2059 , A61K9/4866 , A61K31/27 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/473 , A61K31/55 , A61K45/06 , C07D211/44 , C07D401/12 , A61K2300/00
摘要： The present invention relates to new histamine H3 (H3) receptor subtype selective ligands of the general formula (I) and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and the use of these compounds as medicaments for treatment and/or prevention of conditions which require modulation of H3 receptors. The invention also cover the combinations of a compound of the general formula (I) and an acetylcholinesterase inhibitor.
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10.发明授权PROCESS FOR THE PRODUCTION OF 21-METHOXY-11-BETA-PHENYL-19-NOR-PREGNA-4,9-DIENE-3,20-DIONE DERIVATIVES 有权生产21-甲氧基-11β-苯基-19-去甲孕甾-4,9-二烯-3,20-二酮衍生物的方法
公开(公告)号：EP3107925B1
公开(公告)日：2018-05-16
申请号：EP15708050.8
申请日：2015-02-16
申请人： Richter Gedeon Nyrt.
发明人： MAHÓ, Sándor , SÁNTA, Csaba , CSÖRGEI, János , SZABÓ, Gábor , SCHÄFER, Tamás , BÉNI, Zoltán
CPC分类号： C07J41/0083 , C07J5/0053 , C07J51/00
摘要： The present invention relates to a process for the synthesis of compounds of formula (I), (I) wherein the meaning of R is dimethylamino or acetyl group, using the compound of formula (III) or (IV), wherein the meaning of R' is dimethylamino or 2-methyl-l,3-dioxan-2-yl group, as starting material and methoxymethy] lithium as reagent. (III) (IV)
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