利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.021 秒)

    CARBON MONOXIDE AS A BIOMARKER AND THERAPEUTIC AGENT
    2.
    发明公开
    CARBON MONOXIDE AS A BIOMARKER AND THERAPEUTIC AGENT 审中-公开
    一氧化碳使用本地化的肾脏炎症的治疗

    公开(公告)号：EP1501523A1

    公开(公告)日：2005-02-02

    申请号：EP02807413.6

    申请日：2002-05-09

    申请人： Yale University ,  The Johns Hopkins University,School of Medicine,Office of Technology Licencing

    发明人： CHOI, Augustine, M., K. ,  OTTERBEIN, Leo, E.

    IPC分类号： A61K33/00

    CPC分类号： A61K33/00

    摘要： The present invention relates to the use of carbon monoxide (CO) as a biomarker and therapeutic agent of heart, lung, liver, spleen, brain, skin and kidney diseases and other conditions and disease states including, for example, asthma, emphysema, bronchitis, adult respiratory distress syndrome, sepsis, cystic fibrosis, pneumonia, interstitial lung diseases, idiopathic pulmonary diseases, other lung diseases including primary pulmonary hypertension, secondary pulmonary hypertension, cancers, including lung, larynx and throat cancer, arthritis, wound healing, Parkinson's disease, Alzheimer's disease, peripheral vascular disease and pulmonary vascular thrombotic diseases such as pulmonary embolism. CO may be used to provide anti-inflammatory relief in patients suffering from oxidative stress and other conditions especially including sepsis and septic shock. In addition, carbon monoxide may be used as a biomarker or therapeutic agent for reducing respiratory distress in lung transplant patients and to reduce or inhibit oxidative stress and inflammation in transplant patients.

    METHOD AND APPARATUS OF MASS-CORRELATED PULSED EXTRACTION FOR A TIME-OF-FLIGHT MASS SPECTROMETER
    4.
    发明公开
    METHOD AND APPARATUS OF MASS-CORRELATED PULSED EXTRACTION FOR A TIME-OF-FLIGHT MASS SPECTROMETER 审中-公开
    用于飞行时间质谱仪的质量相关脉冲提取的方法和设备

    公开(公告)号：EP1227875A1

    公开(公告)日：2002-08-07

    申请号：EP00948499.9

    申请日：2000-06-07

    申请人： The Johns Hopkins University,School of Medicine,Office of Technology Licencing

    发明人： KOVTOUN, Viatcheslav, V. ,  COTTER, Robert, J.

    IPC分类号： B01D59/44 ,  H01J49/00

    CPC分类号： H01J49/40

    摘要： A time-of-flight mass spectrometer includes a sample holder (116-118) for a sample and an ionizer (135-139) for ionizing the sample to form ions. A first element (122) is spaced downstream from the sample holder, a second element (123) is spaced downstream from the first element, and a drift region (104) is downstream of the second element. An electric field is established between the sample holder and the first element at a time subsequent to ionizing the sample in order to extract the ions. A time-dependent and mass-correlated electric field is established between at least one of: (a) the first element and the second element, and (b) the sample holder and the first element. In turn, a detector (132) detects the ions.

    摘要翻译： 飞行时间质谱仪包括用于样品的样品保持器（116-118）和用于离子化样品以形成离子的离子发生器（135-139）。 第一元件（122）在样品架下游间隔开，第二元件（123）在第一元件下游间隔开，漂移区（104）在第二元件下游。 在离子化样品以提取离子之后，在样品架和第一元件之间建立电场。 在（a）第一元素和第二元素，以及（b）样品架和第一元件中的至少一个之间建立时间依赖和质量相关的电场。 进而，检测器（132）检测离子。

    Treating cancer by increasing intracellular malonyl coA levels
    8.
    发明公开
    Treating cancer by increasing intracellular malonyl coA levels 审中-公开
    Behandlung von Krebs durchErhöhungdes Malonyl-coA-Spiegels

    公开(公告)号：EP1728510A2

    公开(公告)日：2006-12-06

    申请号：EP06012623.2

    申请日：2000-11-13

    申请人： The Johns Hopkins University, School of Medicine, Office of Technology Licencing

    发明人： Pizer, Ellen S. ,  Townsend, Craig A. ,  Kuhajda, Francis P.

    IPC分类号： A61K31/365 ,  A61K31/341 ,  A61K45/06 ,  G01N33/50 ,  A61K31/00

    CPC分类号： G01N33/5011 ,  A61K31/00 ,  A61K31/34 ,  A61K31/365 ,  A61K45/06 ,  G01N2510/00 ,  A61K2300/00

    摘要： This invention describes a method to kill cancer cells by acute elevation of cellular malonyl Coenzyme A (Malonyl CoA) which leads to apoptosis. Elevation of malonyl CoA may be induced by inhibition of fatty acid synthase (FAS), or by other manipulation of fatty acid metabolism tht does not involve inhibition of FAS. Alternatively, growth of tumor cells may be induced by a combination of effects including FAS inhibition in conjunction with other interventions which affect fatty acid metabolism, including inhibition of camitine palmitoyltransferase-1 (CPT-1). Any combination of drugs which produces an analogous physiologic effect(s) may be expected to lead to the same effect on susceptible tumor cells. For example, combination therapy with drug(s) that inhibit the fatty acid synthesis by inhibiting acetyl CoA carboxylase (the first enzyme in the fatty acid synthesis pathway) and drug(s) that inhibit CPT-1 may be expected to induce apoptosis in tumor cells. Therefore, this invention encompasses any method to systemically modify fatty acid metabolism in cancer cells including but not limited to direct inhibition of CPT-1 through small molecule inhibitors such as etomoxir, as well as inhibition of CPT-1 incidental to increasing the level of malonyl CoA in cancer cells.

    摘要翻译： 本发明描述了通过促进细胞凋亡的细胞丙二酰辅酶A（丙二酰辅酶A）的急性升高来杀死癌细胞的方法。 丙二酰辅酶A的升高可以通过抑制脂肪酸合成酶（FAS）或通过脂肪酸代谢的其它操作来诱导，不涉及FAS的抑制。 或者，肿瘤细胞的生长可以通过包括FAS抑制与影响脂肪酸代谢的其它干预措施（包括抑制camitine palmitoyltransferase-1（CPT-1））的作用的组合来诱导。 产生类似生理作用的药物的任何组合可能预期对易感的肿瘤细胞产生相同的作用。 例如，通过抑制乙酰辅酶A羧化酶（脂肪酸合成途径中的第一个酶）抑制脂肪酸合成的药物和抑制CPT-1的药物的组合疗法可以预期诱导肿瘤细胞凋亡 细胞。 因此，本发明包括用于系统地修饰癌细胞中的脂肪酸代谢的任何方法，包括但不限于通过小分子抑制剂如依托莫司直接抑制CPT-1，以及抑制CPT-1附带增加丙二酰的水平 CoA在癌细胞中。