公开(公告)号：EP4195923A1

公开(公告)日：2023-06-21

申请号：EP21856675.0

申请日：2021-08-11

Applicant: Cellacure LLC

Inventor： ORZA, Anamaria

IPC: A01N25/10 ,  A23L33/105 ,  B01D11/02 ,  C05C3/00

公开(公告)号：EP4177536A1

公开(公告)日：2023-05-10

申请号：EP21206240.0

申请日：2021-11-03

Applicant: Aella SA

Inventor： TEPIC, Slobodan

IPC: F24S10/50 ,  F24S60/10 ,  F24S60/30 ,  F24S90/00

Abstract: The present invention discloses a solar heat powerplant utilizing the full cycle of potential radiative heat exchange between the Sun, the Earth, and deep space. Utilization of radiative cooling during night hours combined with irradiation during the day provides approximately doubling of theoretical efficiency when compared with conventional solar power capture schemes without light concentration.

公开(公告)号：EP4172109A1

公开(公告)日：2023-05-03

申请号：EP21734360.7

申请日：2021-06-25

Applicant: SCA Forest Products AB

Inventor： KUMAR, Shushil ,  KUGGE, Christian

IPC: C01G1/00

公开(公告)号：EP4149619A1

公开(公告)日：2023-03-22

申请号：EP21723779.1

申请日：2021-05-11

Applicant: Kyon Biotech AG

Inventor： TEPIC, Slobodan

IPC: A61P11/00 ,  A61P31/14 ,  A61K38/50

公开(公告)号：EP4135605A1

公开(公告)日：2023-02-22

申请号：EP21788310.7

申请日：2021-04-14

Applicant: Senseonics, Incorporated

Inventor： CHAVAN, Abhi ,  HAYS, Bryan ,  CITIRIK, Erman

IPC: A61B17/32 ,  A61B17/00 ,  A61B17/30 ,  A61B17/34

公开(公告)号：EP4011877A2

公开(公告)日：2022-06-15

申请号：EP21213891.1

申请日：2021-12-10

Applicant: Institut de Cardiologie de Montréal ,  Affina Biotechnologies, Inc.

Inventor： BEREZOV, Alan ,  VINITSKY, Alexander ,  POIRIER, Steve ,  MAYER, Gaétan

IPC: C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/10 ,  C07D487/04 ,  C07D491/04 ,  C07D491/10 ,  A61K31/506 ,  A61K31/5025 ,  A61K45/06 ,  A61P3/06

Abstract: The present invention relates to compounds of Table 1, which are encompassed by Formula I and/or Formula II, III, IV, V, or VI, and pharmaceutically acceptable salts, solvates or compositions thereof. Compounds of Table 1 are PCSK9 interacting small molecules that modulate PCSK9 activity and significantly increase low density lipoprotein receptor expression and activity, lower total circulating cholesterol and are useful for treating and delaying the onset of diseases that are associated with elevated cholesterol.

公开(公告)号：EP3988654A1

公开(公告)日：2022-04-27

申请号：EP21190187.1

申请日：2014-08-28

Applicant: Sangamo Therapeutics, Inc.

Inventor： PASCHON, David ,  ZHANG, Lei

IPC: C12N9/22 ,  C12N15/01 ,  C12N15/90 ,  C12N15/62 ,  A61P31/00 ,  A61P35/00 ,  A61P43/00

Abstract: Disclosed herein are compositions for linking DNA-binding domains and cleavage domains to form nucleases, for example nucleases with altered target site separation (gap) preferences as compared to conventional linkers. Also described are fusion proteins comprising these linkers. The disclosure also provides methods of using these fusion proteins and compositions thereof for targeted cleavage of cellular chromatin in a region of interest and/or homologous recombination at a predetermined region of interest in cells. Thus, in one aspect, described herein are amino acid sequences linking a DNA-binding domain to a cleavage domain. The linker may replace one or more residues of the DNA-binding domain and/or cleavage domain.

公开(公告)号：EP3976774A1

公开(公告)日：2022-04-06

申请号：EP20727671.8

申请日：2020-05-28

Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

Inventor： SCHUMAN, Erin M. ,  HEUMÜLLER, Maximilian ,  GLOCK, Caspar

IPC: C12N9/24 ,  A61K48/00 ,  C12N15/63 ,  C07K14/415

公开(公告)号：EP3954767A1

公开(公告)日：2022-02-16

申请号：EP21764687.6

申请日：2021-03-04

Applicant: CJ Cheiljedang Corporation

Inventor： CHOI, Su Jin ,  LEE, Imsang ,  KIM, Heeyeong ,  KIM, Byeong Soo ,  LEE, Kwang Woo

IPC: C12N9/00 ,  C12N15/77 ,  C12P13/14

Abstract: The present disclosure relates to a modified polypeptide of glutamine synthetase having enhanced activity and a method of producing L-glutamine using the same. Since production of L-glutamine may be increased by using the novel modified polypeptide without a decrease in a growth rate compared to wild-type strains having glutamine synthetase activity, the modified polypeptide may be widely used for mass production of L-glutamine.

公开(公告)号：EP3944826A1

公开(公告)日：2022-02-02

申请号：EP20188448.3

申请日：2020-07-29

Applicant: Kyon AG

Inventor： TEPIC, Slobodan ,  BRESINA, Stephen

IPC: A61B17/16 ,  A61B17/14 ,  A61B17/15

Abstract: The present invention provides a surgical instrument for performing closing wedge osteotomies by a single step procedure: the saw blade has a thickness that increases from t at its lower end towards T at its upper end, whereby the lower end corresponds to the leading edge, which is provided with teeth (3). This thickness may increase step-wise (steps 8).