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公开(公告)号：EP3895052A1
公开(公告)日：2021-10-20
申请号：EP19896568.3
申请日：2019-12-13
申请人： Bluebird Bio, Inc.
IPC分类号： G06F21/72
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公开(公告)号：EP3724227A1
公开(公告)日：2020-10-21
申请号：EP18887392.1
申请日：2018-12-14
申请人： Bluebird Bio, Inc.
发明人： NEGRE, Olivier
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公开(公告)号：EP3714941A1
公开(公告)日：2020-09-30
申请号：EP19165387.2
申请日：2019-03-27
IPC分类号： A61P35/00 , C07K14/47 , C07K14/725 , A61K38/00
摘要： The present invention relates to an isolated T cell receptor (TCR) specific for MAGE-A4 and a polypeptide comprising a functional portion of the TCR. Further implicated are a multivalent TCR complex, a nucleic acid encoding a TCR, a cell expressing the TCR and a pharmaceutical composition comprising the TCR. The invention also refers to the TCR for use as a medicament, in particular to the TCR for use in the treatment of cancer.
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公开(公告)号：EP3689899A1
公开(公告)日：2020-08-05
申请号：EP19218258.2
申请日：2015-04-24
申请人： Bluebird Bio, Inc.
发明人： MORGAN, Richard , FRIEDMAN, Kevin , RYU, Byoung
IPC分类号： C07K14/705 , C07K16/30 , C12N15/85 , C12N5/00 , C12N5/071 , C07K16/28 , A61K39/00 , A61K48/00 , C07K14/725 , C12N5/0783 , C12N7/00 , C12N15/86 , A61P35/00 , A61P35/02 , A61P35/04 , A61P43/00 , A61P37/04
摘要： The invention provides vector compositions for delivering improved adoptive T cell therapies.
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公开(公告)号：EP3656848A1
公开(公告)日：2020-05-27
申请号：EP19204363.6
申请日：2012-09-28
申请人： Bluebird Bio, Inc.
摘要： The present invention provides methods and compositions for improving the efficacy of viral transduction of cells. More particularly, the present invention provides methods and materials useful for safely and reliably improving the efficiency of methods for transducing cells, such as human hematopoietic stem cells (HSC), with viruses and/or viral vectors. The compositions and methods are useful for therapeutic indications amenable to treatment with hematopoietic stem cell gene therapies.
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公开(公告)号：EP3134432B1
公开(公告)日：2019-12-25
申请号：EP15782739.5
申请日：2015-04-24
申请人： Bluebird Bio, Inc.
发明人： MORGAN, Richard , FRIEDMAN, Kevin , RYU, Byoung
IPC分类号： C07K14/705 , C07K16/30 , C12N15/85 , C12N5/00 , C12N5/071 , C07K16/28 , A61K39/00 , A61K48/00 , C07K14/725 , C12N5/0783 , C12N7/00 , C12N15/86
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公开(公告)号：EP3230321B1
公开(公告)日：2019-08-28
申请号：EP15868392.0
申请日：2015-12-07
申请人： Bluebird Bio, Inc.
发明人： MORGAN, Richard , FRIEDMAN, Kevin
IPC分类号： C07K16/28 , A61K39/00 , C07K14/005 , C07K14/725 , A61K48/00 , C12N15/86 , C12N15/62 , C12N5/0783
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公开(公告)号：EP3443002A1
公开(公告)日：2019-02-20
申请号：EP17783220.1
申请日：2017-04-14
申请人： Bluebird Bio, Inc.
发明人： LEUNG, Wai-Hang
IPC分类号： C07K14/705 , C07K14/725 , C07K16/28 , C07K19/00 , C12N15/62
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公开(公告)号：EP3269802A1
公开(公告)日：2018-01-17
申请号：EP17173567.3
申请日：2012-09-28
申请人： Bluebird Bio, Inc.
CPC分类号： C12N15/86 , A61K38/46 , A61K2035/124 , C12N5/0647 , C12N15/867 , C12N2501/02 , C12N2510/00 , C12N2740/16043 , C12N2810/6081
摘要： The present invention provides methods and compositions for improving the efficacy of viral transduction of cells. More particularly, the present invention provides methods and materials useful for safely and reliably improving the efficiency of methods for transducing cells, such as human hematopoietic stem cells (HSC), with viruses and/or viral vectors. The compositions and methods are useful for therapeutic indications amenable to treatment with hematopoietic stem cell gene therapies.
摘要翻译： 本发明提供了用于改善病毒转导细胞效力的方法和组合物。 更具体地说，本发明提供了用于安全和可靠地提高用病毒和/或病毒载体转导诸如人造血干细胞（HSC）的细胞的方法的效率的方法和材料。 该组合物和方法可用于适合用造血干细胞基因疗法治疗的治疗适应症。
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