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公开(公告)号：EP3907292A1
公开(公告)日：2021-11-10
申请号：EP21178885.6
申请日：2017-03-02
发明人： EDEN, Eran , OVED, Kfir , COHEN-DOTAN, Assaf , NAVON, Roy , BOICO, Olga , KRONENFELD, Gali , SIMON, Einav
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/569 , C12Q1/689 , C12Q1/70
摘要： A method of selecting an exon of an RNA whose expression level is informative with respect to infection type of a subject is disclosed. The method comprises comparing the expression level of the RNA in a sample derived from a bacterially-infected subject and a sample derived from a virally-infected subject at a plurality of exons, wherein the exon that provides a differential expression between the bacterially-infected subject above a predetermined level is selected as the exon of the RNA whose expression is informative with respect to infection type.
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公开(公告)号：EP3482201A1
公开(公告)日：2019-05-15
申请号：EP17827122.7
申请日：2017-07-10
发明人： EDEN, Eran , OVED, Kfir , COHEN-DOTAN, Assaf , NAVON, Roy , BOICO, Olga , PAZ, Meital
IPC分类号： G01N33/53 , G01N33/569
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3.发明公开MARKER COMBINATIONS FOR DIAGNOSING INFECTIONS AND METHODS OF USE THEREOF 审中-公开用于诊断感染的MARKER组合及其使用方法
公开(公告)号：EP3230740A1
公开(公告)日：2017-10-18
申请号：EP15868614.7
申请日：2015-12-10
发明人： OVED, Kfir , EDEN, Eran , KRONENFELD, Gali , BOICO, Olga , COHEN-DOTA, Assaf , NAVON, Roy
IPC分类号： G01N33/569
CPC分类号： G01N33/56911 , G01N33/56966 , G01N33/56983 , G01N2800/26 , G01N2800/60
摘要： A method of determining an infection type in a subject is disclosed. The method comprises measuring the concentration of a first determinant selected from the group consisting of the determinants which are set forth in Table 1 and a second determinant selected from the group of the determinants which are set forth in Table 2 in a subject derived sample, wherein the concentration is indicative of the infection type.
摘要翻译： 公开了一种确定受试者的感染类型的方法。 该方法包括在受试者衍生的样品中测量选自表1中列出的决定簇的第一决定簇的浓度和选自表2中列出的决定簇的第二决定簇的浓度，其中 浓度指示感染类型。
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公开(公告)号：EP3519833A1
公开(公告)日：2019-08-07
申请号：EP17855163.6
申请日：2017-09-27
发明人： EDEN, Eran , OVED, Kfir , COHEN-DOTAN, Assaf , NAVON, Roy , BOICO, Olga , PAZ, Meital
IPC分类号： G01N33/68
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公开(公告)号：EP3367099A1
公开(公告)日：2018-08-29
申请号：EP18162713.4
申请日：2013-02-08
发明人： OVED, Kfir , EDEN, Eran , IFERGAN, Ilan
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , G01N27/447 , G01N27/44726 , G01N27/44739 , G01N33/56911 , G01N33/6863 , G01N33/6866 , G01N2333/70575 , G01N2800/52
摘要： The present invention concerns a kit comprising antibodies, wherein a first antibody of said antibodies binds to a protein selected from the group consisting of TRAIL, IL1RA, IP10, B2M, BCA-1, CHI3L1, Eotaxin, IL1a, MCP, Mac-2BP, CD62L, VEGFR2, CHP, CMPK2, CORO1C, EIF2AK2, ISG15, RPL22L1, RTN3, CD112, CD134, CD182, CD231, CD235A, CD335, CD337, CD45, CD49D, CD66A/C/D/E, CD73, CD84, EGFR, GPR162, HLA-A/B/C, ITGAM, NRG1, RAP1B, SELI, SPINT2, SSEA1, IL11, I-TAC and TNFR1, and a second antibody of said antibodies is selected from the group consisting of CRP, SAA, TREM-1, PCT, IL-8 and IL6.
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6.发明公开COMPUTATIONAL ANALYSIS OF BIOLOGICAL DATA USING MANIFOLD AND A HYPERPLANE 审中-公开麻醉师生物学家日内瓦麻醉师VERTEILER UND HYPEREBENE
公开(公告)号：EP3180621A1
公开(公告)日：2017-06-21
申请号：EP15831781.8
申请日：2015-08-12
发明人： EDEN, Eran , OVED, Kfir , NAVON, Roy , COHEN-DOTAN, Assaf , BOICO, Olga
IPC分类号： G01N33/569
摘要： A method of analyzing biological data containing expression values of a plurality of polypeptides in the blood of a subject. The method comprises: calculating a distance between a segment of a curved line and an axis defined by a direction, the distance being calculated at a point over the curved line defined by a coordinate along the direction. The method further comprises correlating the distance to the presence of, absence of, or likelihood that the subject has, a bacterial infection. The coordinate is defined by a combination of the expression values, wherein at least 90% of the segment is between a lower bound line and an upper bound line.
摘要翻译： 一种分析含有受试者血液中多种多肽表达值的生物数据的方法。 该方法包括：计算曲线段和由方向限定的轴之间的距离，所述距离在由沿着该方向的坐标定义的曲线上的点处计算。 该方法还包括将距离与受试者的存在，不存在或可能性相关联的细菌感染。 坐标由表达值的组合定义，其中该段的至少90％在下限线和上限线之间。
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公开(公告)号：EP4141448A1
公开(公告)日：2023-03-01
申请号：EP22169859.0
申请日：2017-07-10
发明人： EDEN, Eran , OVED, Kfir , COHEN-DOTAN, Assaf , NAVON, Roy , BOICO, Olga , KRONENFELD, Gali , PAZ, Meital , BAMBERGER, Ellen
摘要： Methods of diagnosing infections are disclosed. In one embodiment, the method comprises measuring the amount of each of the polypeptides TRAIL and IP 10 and at least one additional polypeptide selected from the group consisting of IL-6 and PCT.
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公开(公告)号：EP3504553A1
公开(公告)日：2019-07-03
申请号：EP17838930.0
申请日：2017-08-10
发明人： OVED, Kfir , EDEN, Eran , NAVON, Roy , COHEN-DOTAN, Assaf , KRONENFELD, Gali , BOICO, Olga
IPC分类号： G01N33/569
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公开(公告)号：EP3482200A1
公开(公告)日：2019-05-15
申请号：EP17827121.9
申请日：2017-07-10
发明人： EDEN, Eran , OVED, Kfir , COHEN-DOTAN, Assaf , NAVON, Roy , BOICO, Olga , KRONENFELD, Gali , PAZ, Meital , BAMBERGER, Ellen
IPC分类号： G01N33/53 , G01N33/569 , G06F17/18 , G06F19/12 , G06F19/24
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公开(公告)号：EP3423589A1
公开(公告)日：2019-01-09
申请号：EP17759388.6
申请日：2017-03-02
发明人： EDEN, Eran , OVED, Kfir , COHEN-DOTAN, Assaf , NAVON, Roy , BOICO, Olga , KRONENFELD, Gali , SIMON, Einav
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/569
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