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    HETEROCYCLIC MORPHINAN DERIVATIVES AND USE THEREOF
    8.
    发明公开
    HETEROCYCLIC MORPHINAN DERIVATIVES AND USE THEREOF 审中-公开

    公开(公告)号：EP3154971A4

    公开(公告)日：2017-11-01

    申请号：EP15805783

    申请日：2015-06-12

    申请人： PURDUE PHARMA LP

    发明人： TAFESSE LAYKEA ,  YOUNGMAN MARK A

    IPC分类号： C07D471/08

    CPC分类号： C07D471/08

    摘要： The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and Z are defined as set forth in the specification. In certain embodiments, the invention is also directed to compounds of Formula II-VII and the pharmaceutically acceptable salts and solvates thereof. The invention is also directed to use of compounds of Formula I to VII, and the pharmaceutically acceptable salts and solvates thereof, to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the invention are especially useful for treating pain.

    6.7-CYCLICMORPHINAN DERIVATIVES AND USE THEREOF
    9.
    发明公开
    6.7-CYCLICMORPHINAN DERIVATIVES AND USE THEREOF 审中-公开
    6.7-环M胺衍生物及其用途

    公开(公告)号：EP3227293A1

    公开(公告)日：2017-10-11

    申请号：EP15866208.0

    申请日：2015-12-03

    申请人： Purdue Pharma L.P.

    发明人： KASSICK, Andrew ,  TADESSE, Dawit ,  TAFESSE, Laykea

    IPC分类号： C07D471/08 ,  A61K31/438

    CPC分类号： C07D471/08 ,  C07D498/08

    摘要： The application provides compounds of Formula I and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, dash line a, dash line b, W, Z, X, and m are defined as set forth in the specification. The invention is also directed to use of the compounds of Formula I and the pharmaceutically acceptable salts and solvates thereof to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. In certain embodiments, the Compounds of the Invention are useful for treating pain.

    摘要翻译： 本申请提供了式I化合物及其药学上可接受的盐和溶剂化物，其中R 1，R 2，R 3，R 4，R 5，虚线a，虚线b，W，Z，X和m定义为 在说明书中提出。 本发明还涉及式I化合物及其药学上可接受的盐和溶剂化物用于治疗对调节一种或多种阿片样受体或对合成中间体有响应的病症的用途。 在某些实施方案中，本发明化合物可用于治疗疼痛。