公开(公告)号：EP4448580A2

公开(公告)日：2024-10-23

申请号：EP22908303.5

申请日：2022-12-13

申请人： University of Pittsburgh - of the Commonwealth System of Higher Education

发明人： DIMITROV, Dimiter Stanchev ,  BAEK, Dusan ,  KIM, Yae Jin ,  MELLORS, John W.

IPC分类号： C07K16/28 ,  A61K38/17 ,  A61P31/12 ,  A61P35/00

公开(公告)号：EP4426281A1

公开(公告)日：2024-09-11

申请号：EP22822722.9

申请日：2022-11-01

申请人： University of Pittsburgh - of the Commonwealth System of Higher Education

发明人： SIMS-LUCAS, Sunder ,  GOETZMAN, Eric S.

IPC分类号： A61K31/20 ,  A61K31/23 ,  A61P1/16 ,  A61P3/00 ,  A61P3/04 ,  A61P13/12 ,  A61P21/00 ,  A61P39/00 ,  A61P43/00

CPC分类号： A61K31/20 ,  A61K31/23 ,  A61P3/04 ,  A61P1/16 ,  A61P21/00 ,  A61P3/00 ,  A61P13/12 ,  A61P39/00 ,  A61P43/00

公开(公告)号：EP4416808A1

公开(公告)日：2024-08-21

申请号：EP22881524.7

申请日：2022-08-12

申请人： University of Pittsburgh - of the Commonwealth System of Higher Education ,  Braindrip, LLC

发明人： OHODNICKI, Paul R. ,  WEISENBERG, Kent ,  SYED, Ibrahiim

IPC分类号： H02G1/08 ,  F16L7/00 ,  G02B6/50 ,  H02G3/38 ,  H02G9/06

CPC分类号： F16L7/00 ,  H02G1/088 ,  G02B6/502 ,  G02B6/504 ,  G02B6/4457

公开(公告)号：EP4324918A3

公开(公告)日：2024-04-24

申请号：EP23215391.6

申请日：2014-08-22

申请人： University of Pittsburgh - of The Commonwealth System of Higher Education

发明人： THORNE, Stephen Howard

IPC分类号： C12N15/39 ,  A61K39/285 ,  A61K35/768 ,  C12N7/00

CPC分类号： C12N2710/2413220130101 ,  A61K39/12 ,  A61K2039/525620130101 ,  A61K2039/57220130101 ,  A61K2039/58520130101 ,  C12N2710/2412120130101 ,  C12N2710/2413420130101 ,  A61K2039/57520130101 ,  A61P35/00 ,  A61P35/02

摘要： The present invention relates to oncolytic vaccinia viruses which have been modified to promote anti-tumor immunity and/or reduce host immunity and/or antibody response against the virus. It is based, at least in part, on the discovery that oncolytic vaccinia virus (i) bearing a genome deletion of a gene that reduces T cell immunity (interleukin-18 binding protein); (ii) treated with a sialidase enzyme which is believed to reduce TLR2 activation and therefore the antibody response; (iii) carrying a gene that enhances cytotoxic T lymphocyte induction (e.g., TRIF) and/or (iv) reduces tumor myeloid-derived suppressor cells by reducing prostaglandin E2 reduces tumor growth. Accordingly, the present invention provides for immunooncolytic vaccinia viruses and methods of using them in the treatment of cancers.

公开(公告)号：EP4334339A2

公开(公告)日：2024-03-13

申请号：EP22799371.4

申请日：2022-05-02

申请人： University of Pittsburgh - of the Commonwealth System of Higher Education ,  Bluesphere Bio, Inc.

发明人： ITO, Sawa ,  SHLOMCHIK, Warren David ,  SHLOMCHIK, Mark Jay ,  PANOUSIS, Constantinos George ,  KIM, Josh ,  MARTIN, Erik ,  WIKENHEISER, Daniel

IPC分类号： C07K14/705

公开(公告)号：EP4333866A1

公开(公告)日：2024-03-13

申请号：EP22799710.3

申请日：2022-05-06

申请人： University of Pittsburgh - of the Commonwealth System of Higher Education

发明人： FALO JR., Louis D. ,  KORKMAZ, Emrullah ,  SUMPTER, Tina L.

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61P37/08

公开(公告)号：EP4305069A1

公开(公告)日：2024-01-17

申请号：EP22767820.8

申请日：2022-03-08

申请人： University of Pittsburgh - of the Commonwealth System of Higher Education

发明人： DIMITROV, Dimiter Stanchev ,  MELLORS, John W. ,  BAEK, Dusan

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61P35/00

公开(公告)号：EP4294442A1

公开(公告)日：2023-12-27

申请号：EP22756786.4

申请日：2022-02-15

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： DIMITROV, Dimiter Stanchev ,  SUN, Zehua ,  MELLORS, John W.

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K9/00 ,  A61P35/00

公开(公告)号：EP4252842A3

公开(公告)日：2023-10-25

申请号：EP23186922.3

申请日：2018-03-02

申请人： University of Pittsburgh- Of the Commonwealth System of Higher Education

发明人： BADYLAK, Stephen Francis ,  NARANJO GUTIERREZ, Juan Diego ,  SALDIN, Lindsey Tamiko

IPC分类号： A61K35/12 ,  A61P1/00

摘要： Methods are disclosed for inhibiting esophageal inflammation in a subject, that include administering to the esophagus of the subject with esophageal inflammation a therapeutically effective amount of an extracellular matrix (ECM) hydrogel. Methods are also disclosed for reducing esophageal stricture. Compositions are disclosed that include an esophageal extracellular matrix (ECM) hydrogel.

公开(公告)号：EP4257202A2

公开(公告)日：2023-10-11

申请号：EP23168344.2

申请日：2012-11-09

申请人： Trustees of Tufts College ,  University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Wake Forest University Health Services

发明人： BELLAS, Evangelia ,  MARRA, Kacey ,  RUBIN, Peter J. ,  KAPLAN, David L. ,  YOO, James J.

IPC分类号： A61P43/00

摘要： The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size. In some embodiments, the composition described herein comprises a plurality of silk fibroin particles, which can retain their original volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.