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公开(公告)号：EP3719006A1
公开(公告)日：2020-10-07
申请号：EP20176556.7
申请日：2016-02-17
Inventor： HECHT, Sidney , KHDOUR, Omar , ALAM, Mohammad , DEY, Sriloy , CHEN, Yana , CHEVALIER, Arnaud
IPC: C07D239/47 , C07D239/52 , C07D401/04 , C07D403/04 , A61K31/505 , A61K31/506 , A61P3/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P25/00 , A61P25/28 , A61P35/00 , A61P25/16 , A61P25/18
Abstract: Pharmaceutical compositions comprising Compounds of formula I
and salts thereof are disclosed.
Also disclosed are isotopes of compounds of formula I of the salts thereof, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I or a pharmaceutical composition thereof.
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公开(公告)号：EP2694478B1
公开(公告)日：2018-08-22
申请号：EP12713835.2
申请日：2012-04-04
Inventor： HECHT, Sidney , KHDOUR, Omar , CHOWDHURY, Sandipan, Roy , TALUKDER, Poulami
IPC: C07D213/74 , A61K31/64 , A61P39/06
CPC classification number: C07D401/06 , C07D211/94 , C07D213/74 , C07D213/89 , C07D279/18 , C07D279/20 , G01N33/5079
Abstract: The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
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公开(公告)号：EP2536690A1
公开(公告)日：2012-12-26
申请号：EP11707268.6
申请日：2011-02-21
Applicant: Arizona Board Of Regents
Inventor： HECHT, Sidney , ARMSTRONG, Jeffrey , KHDOUR, Omar , LU, Jun , ARCE, Pablo
IPC: C07D213/74 , C07D237/22 , C07D239/42 , A61K31/415 , A61K31/4164 , A61K31/4192 , A61P39/06
CPC classification number: C07D239/47 , C07D213/73 , C07D213/74 , C07D237/22 , C07D239/42 , C07D239/52 , C07D403/04 , C07D471/04
Abstract: The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
Abstract translation: 本公开提供了式（I）的生物活性化合物及其药学上可接受的盐：包含这些化合物的组合物，以及在各种应用中使用这些化合物的方法，例如治疗或抑制与减少的线粒体功能相关的疾病，导致 减少ATP产生和/或氧化应激和/或脂质过氧化。
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公开(公告)号：EP3259254A1
公开(公告)日：2017-12-27
申请号：EP16752946.0
申请日：2016-02-17
Inventor： HECHT, Sidney , KHDOUR, Omar , ALAM, Mohammad , DEY, Sriloy , CHEN, Yana , CHEVALIER, Arnaud
IPC: C07D239/47 , C07D239/52
CPC classification number: C07D239/47 , C07D239/42 , C07D239/60
Abstract: Compounds of formula (I) and salts are disclosed. Also disclosed are isotopes of compounds of formula I of the salts thereof. Pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I are disclosed.
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公开(公告)号：EP3247801A1
公开(公告)日：2017-11-29
申请号：EP16740844.2
申请日：2016-01-22
Inventor： HECHT, Sidney , DEDKOVAL, Larisa , MAINI, Rumit , ROY CHOWDHURY, Sandipan , PAUL, Rakesh
CPC classification number: C12N15/67 , C07D263/34 , C07D277/593 , C12N9/003 , C12N15/11 , C12Y105/01003
Abstract: Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.
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公开(公告)号：EP3258938A1
公开(公告)日：2017-12-27
申请号：EP16752964.3
申请日：2016-02-17
Inventor： HECHT, Sidney , KHDOUR, Omar , CHOWDHURY, Sandipan Roy , BANDYOPADHAY, Indrajit
IPC: A61K31/5415 , C07D279/18
CPC classification number: C07D279/20 , C07D279/18 , C07D417/04 , C07D417/14
Abstract: The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
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公开(公告)号：EP3258938B1
公开(公告)日：2020-12-02
申请号：EP16752964.3
申请日：2016-02-17
Inventor： HECHT, Sidney , KHDOUR, Omar , CHOWDHURY, Sandipan Roy , BANDYOPADHAY, Indrajit
IPC: A61K31/5415 , C07D279/18
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公开(公告)号：EP2536690B1
公开(公告)日：2018-08-08
申请号：EP11707268.6
申请日：2011-02-21
Applicant: Arizona Board Of Regents
Inventor： HECHT, Sidney , ARMSTRONG, Jeffrey , KHDOUR, Omar , LU, Jun , ARCE, Pablo
IPC: C07D213/74 , C07D237/22 , C07D239/42 , A61K31/415 , A61K31/4164 , A61K31/4192 , A61P39/06
CPC classification number: C07D239/47 , C07D213/73 , C07D213/74 , C07D237/22 , C07D239/42 , C07D239/52 , C07D403/04 , C07D471/04
Abstract: The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof: compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
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公开(公告)号：EP2906207A1
公开(公告)日：2015-08-19
申请号：EP13846151.2
申请日：2013-10-10
Inventor： MADATHIL, Manikandadas, Mathilakathu , KHDOUR, Omar , HECHT, Sidney
IPC: A61K31/122 , C07C50/04
CPC classification number: C07C49/753 , A61K9/0019 , A61K9/008 , A61K9/08 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07C46/02 , C07C225/20 , C07C229/10 , C07D225/06 , C07C50/28
Abstract: The invention provides a compound of formula (I): [insert formula (I)] wherein X, Y, and R1-R4 have any of the values defined in the specification, and salts thereof, as well as compositions comprising the compounds or salts. The compounds are useful for treating diseases associated with impaired mitochondrial function in an animal.
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10.发明公开MULTIFUNCTIONAL RADICAL QUENCHERS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION 审中-公开多功能放大器筷子ZUR BEHANDLUNG VON MITOCHONDRIALER DYSFUNKTION
公开(公告)号：EP2694478A2
公开(公告)日：2014-02-12
申请号：EP12713835.2
申请日：2012-04-04
Inventor： HECHT, Sidney , KHDOUR, Omar , CHOWDHURY, Sandipan, Roy , TALUKDER, Poulami
IPC: C07D213/74 , A61K31/64 , A61P39/06
CPC classification number: C07D401/06 , C07D211/94 , C07D213/74 , C07D213/89 , C07D279/18 , C07D279/20 , G01N33/5079
Abstract: The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
Abstract translation: 本公开提供了用于鉴定作为多功能基团猝灭剂的治疗剂的方法。 它还提供式（I），（II）或（II-A）化合物及其药学上可接受的盐，包含这些化合物的组合物，以及在各种应用中使用这些化合物的方法，例如治疗或抑制 与线粒体功能降低相关的疾病导致ATP产生减少和/或氧化应激和/或脂质过氧化。
