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1.发明授权
公开(公告)号：EP2029600B1
公开(公告)日：2012-03-14
申请号：EP07729158.1
申请日：2007-05-15
IPC分类号： C07D475/08 , A61K31/495 , A61P11/00 , A61P17/00 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines of formula (1), suitable for the treatment of airway or gastrointestinal complaints or diseases, inflammatory diseases of the joints, the skin or eyes, diseases of the peripheral or central nervous systems or cancerous diseases and pharmaceutical compositions comprising said compounds.
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2.发明授权DIHYDROTHIENOPYRIMIDINE ZUR BEHANDLUNG VON ENTZÜNDLICHEN ERKRANKUNGEN 有权Dihydrothienopyrimidines炎症性疾病的治疗
公开(公告)号：EP1874781B1
公开(公告)日：2009-06-24
申请号：EP06743350.8
申请日：2006-04-19
IPC分类号： C07D495/04 , A61P11/00 , A61K31/519
CPC分类号： C07D521/00 , C07D495/04 , C07D519/00
摘要： The invention relates to novel dihydrothienopyrimidines of formula (1) as well as pharmaceutically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of ailments or diseases of the respiratory tract, gastrointestinal ailments or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system, or cancer diseases. Also disclosed are pharmaceutical compositions containing the inventive compounds.
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公开(公告)号：EP2079725B1
公开(公告)日：2011-12-14
申请号：EP07821817.9
申请日：2007-10-25
IPC分类号： C07D401/04 , C07D401/14 , A61K31/4439 , A61P11/06 , A61P29/00 , A61P37/08
CPC分类号： C07D401/04 , C07D401/14
摘要： One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R1, R2, R3 and R4 are defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明的一个目的是式（1）的新型取代的哌啶基 - 丙烷 - 硫醇，其中R1，R2，R3和R4如下所定义。 本发明的另一目的是提供CCR-3或其药学上可接受的盐的激动剂或拮抗剂，更具体地说是提供药物组合物，其包含药学上可接受的载体和治疗有效量的至少一种本发明化合物 或其药学上可接受的盐。
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公开(公告)号：EP2079731A1
公开(公告)日：2009-07-22
申请号：EP07821818.7
申请日：2007-10-25
IPC分类号： C07D401/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K31/454 , A61P29/00
CPC分类号： C07D401/14 , C07D401/04 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R1, R2, R3 and D are defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明的一个目的是式（1）的新型取代的哌啶基 - 丙烷 - 硫醇，其中R1，R2，R3和D如下定义。 本发明的另一目的是提供CCR-3或其药学上可接受的盐的激动剂或拮抗剂，更具体地说是提供药物组合物，其包含药学上可接受的载体和治疗有效量的至少一种本发明化合物 或其药学上可接受的盐。
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5.发明公开DIHYDROTHIENOPYRIMIDINE ZUR BEHANDLUNG VON ENTZÜNDLICHEN ERKRANKUNGEN 有权Dihydrothienopyrimidines炎症性疾病的治疗
公开(公告)号：EP1874781A1
公开(公告)日：2008-01-09
申请号：EP06743350.8
申请日：2006-04-19
IPC分类号： C07D495/04 , A61P11/00 , A61K31/519
CPC分类号： C07D521/00 , C07D495/04 , C07D519/00
摘要： The invention relates to novel dihydrothienopyrimidines of formula (1) as well as pharmaceutically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of ailments or diseases of the respiratory tract, gastrointestinal ailments or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system, or cancer diseases. Also disclosed are pharmaceutical compositions containing the inventive compounds.
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6.发明公开SUBSTITUIERTE PTERIDINE ZUR BEHANDLUNG VON ENTZ]NDLICHEN ERKRANKUNGEN 审中-公开SUTITANTERTE PTERIDINE ZUR BEHANDLUNG VON ENTZ] NDLICHEN ERKRANKUNGEN
公开(公告)号：EP1824854A2
公开(公告)日：2007-08-29
申请号：EP05823962.5
申请日：2005-11-25
IPC分类号： C07D475/08 , A61K31/519 , A61P35/00
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines which are suitable for treating respiratory or gastrointestinal complaints or diseases, joint, skin or eye inflammatory diseases, disease of the periphery or central nervous system or cancer. The invention also relates to pharmaceutical compositions containing said compounds.
摘要翻译： 本发明涉及适用于治疗呼吸或胃肠疾病，关节，皮肤或眼睛炎性疾病，外周或中枢神经系统疾病或癌症的新型蝶啶。 本发明还涉及含有所述化合物的药物组合物。
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公开(公告)号：EP2079725A1
公开(公告)日：2009-07-22
申请号：EP07821817.9
申请日：2007-10-25
IPC分类号： C07D401/04 , C07D401/14 , A61K31/4439 , A61P11/06 , A61P29/00 , A61P37/08
CPC分类号： C07D401/04 , C07D401/14
摘要： One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R1, R2, R3 and R4 are defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
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8.发明公开
公开(公告)号：EP1994019A2
公开(公告)日：2008-11-26
申请号：EP06743381.3
申请日：2006-04-26
发明人： MARTYRES, Domnic , POUZET, Pascale , HOENKE, Christoph , SEITHER, Peter , HOBBIE, Silke , BOUYSSOU, Thierry
IPC分类号： C07D401/04 , A61K31/454
CPC分类号： C07D401/04
摘要： Accordingly, one object of the present invention are novel piperidine-substituted indoles- or heteroderivatives thereof of the formula (I), wherein R1, R5, R6, R7, A, B, D-E, Y, i, j, n and m are defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
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9.发明公开VERWENDUNG VON SUBSTITUIERTEN PTERIDINEN ZUR BEHANDLUNG VON ATEMWEGSERKRANKUNGEN 审中-公开取代蝶啶类的呼吸系统疾病治疗中的应用
公开(公告)号：EP1708715A1
公开(公告)日：2006-10-11
申请号：EP05700802.1
申请日：2005-01-11
发明人： NICKOLAUS, Peter , MEADE, Christopher J. Montague , DOLLINGER, Horst , MACK, Jürgen , DAHMANN, Georg , MARTYRES, Domnic , JUNG, Birgit
IPC分类号： A61K31/519 , A61P11/00 , A61P11/06
CPC分类号： A61K31/525 , A61K31/519 , A61K31/5377 , A61K31/541
摘要： The invention relates to the use of pteridines for the treatment of inflammatory and obstructive diseases of the respiratory tract, preferably asthma or COPD, and pharmaceutical compounds containing said compounds.
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公开(公告)号：EP2032585B1
公开(公告)日：2014-07-23
申请号：EP07765267.5
申请日：2007-05-15
发明人： DOLLINGER, Horst , MARTYRES, Domnic , MACK, Juergen , GOEGGEL, Rolf , JUNG, Birgit , NICKOLAUS, Peter
IPC分类号： C07D519/00 , C07D475/08 , A61K31/519 , A61K31/55 , A61P35/00
CPC分类号： C07D475/08 , C07D519/00
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