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    BICYCLIC AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES
    3.
    发明公开
    BICYCLIC AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES 有权
    双环酰胺类，以提高谷氨酸突触反应

    公开(公告)号：EP2187888A2

    公开(公告)日：2010-05-26

    申请号：EP08795126.5

    申请日：2008-08-08

    Applicant: CORTEX PHARMACEUTICALS, INC.

    Inventor： MUELLER, Rudolf ,  STREET, Leslie

    IPC: A61K31/519 ,  A61K31/53 ,  C07D498/04 ,  C07D265/24

    CPC classification number: A61K31/46 ,  A61K31/4245 ,  A61K31/439 ,  A61K31/519 ,  A61K31/53 ,  A61K45/06 ,  C07D209/52 ,  C07D451/02 ,  C07D451/04 ,  C07D451/06 ,  C07D453/06 ,  C07D471/08 ,  C07D487/08 ,  C07D491/08

    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning, hi a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.

    DI-SUBSTITUTED AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES
    4.
    发明公开
    DI-SUBSTITUTED AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES 有权
    二取代酰胺类，以提高谷氨酸突触反应

    公开(公告)号：EP2154970A1

    公开(公告)日：2010-02-24

    申请号：EP08767737.3

    申请日：2008-05-16

    Applicant: CORTEX PHARMACEUTICALS, INC.

    Inventor： STREET, Leslie ,  MUELLER, Rudolf ,  LEE, Stephen

    IPC: A01N43/82 ,  A61K31/41

    CPC classification number: A61K31/4245 ,  A61K45/06 ,  C07D271/12 ,  C07D285/14 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke- induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning. In a particular aspect, the invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.

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