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公开(公告)号：EP1250340A1
公开(公告)日：2002-10-23
申请号：EP00986242.6
申请日：2000-12-11
Applicant: ELI LILLY AND COMPANY , Wang, Qiuping
Inventor： BONJOUKLIAN, Rosanne , COHEN, Jeffrey, Daniel , GRUBER, Joseph, Michael , JOHNSON, Douglas, Webb , JUNGHEIM, Louis, Nickolaus , KROIN, Julian, Stanley , LANDER, Peter, Ambrose , LIN, Ho-Shen , LOHMAN, Mark, Christopher , MUEHL, Brian, Stephen , NORMAN, Bryan, Hurst , PATEL, Vinod, Francis , RICHETT, Michael, Enrico , THRASHER, Kenneth, Jeff , VEPACHEDU, Sreenivasarao , WHITE, Wesley, Todd , XIE, Yongping , YORK, Jeremy Schulenburg , PARKHURST, Brandon, Lee , WANG, Quiping
IPC: C07D498/04 , A61K31/47 , A61P35/00 , A61P43/00
CPC classification number: C07D471/04
Abstract: The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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2.发明公开
公开(公告)号：EP1224189A2
公开(公告)日：2002-07-24
申请号：EP00968314.5
申请日：2000-09-22
Applicant: ELI LILLY AND COMPANY
Inventor： BONJOUKLIAN, Rosanne , JOHNSON, Douglas, Webb , LANDER, Peter, Ambrose , LOHMAN, Mark, Christopher , PATEL, Vinod, Francis , VEPACHEDU, Sreenivasarao , XIE, Yongping
IPC: C07D498/04 , C07D471/04 , A61K31/4741 , A61K31/4745 , A61P35/00
CPC classification number: C07D471/04
Abstract: The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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3.发明授权
公开(公告)号：EP1224189B1
公开(公告)日：2006-01-25
申请号：EP00968314.5
申请日：2000-09-22
Applicant: ELI LILLY AND COMPANY
Inventor： BONJOUKLIAN, Rosanne , JOHNSON, Douglas, Webb , LANDER, Peter, Ambrose , LOHMAN, Mark, Christopher , PATEL, Vinod, Francis , VEPACHEDU, Sreenivasarao , XIE, Yongping
IPC: C07D498/04 , C07D471/04 , A61K31/4741 , A61K31/4745 , A61P35/00 , C07D261/00 , C07D221/00 , C07D231/00 , C07D263/00
CPC classification number: C07D471/04
Abstract: The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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公开(公告)号：EP1250340B1
公开(公告)日：2004-11-17
申请号：EP00986242.6
申请日：2000-12-11
Applicant: ELI LILLY AND COMPANY
Inventor： BONJOUKLIAN, Rosanne , COHEN, Jeffrey, Daniel , GRUBER, Joseph, Michael , JOHNSON, Douglas, Webb , JUNGHEIM, Louis, Nickolaus , KROIN, Julian, Stanley , LANDER, Peter, Ambrose , LIN, Ho-Shen , LOHMAN, Mark, Christopher , MUEHL, Brian, Stephen , NORMAN, Bryan, Hurst , PATEL, Vinod, Francis , RICHETT, Michael, Enrico , THRASHER, Kenneth, Jeff , VEPACHEDU, Sreenivasarao , WHITE, Wesley, Todd , XIE, Yongping , YORK, Jeremy Schulenburg , PARKHURST, Brandon, Lee , WANG, Quiping
IPC: C07D498/04 , A61K31/47 , A61P35/00 , A61P43/00
CPC classification number: C07D471/04
Abstract: The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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公开(公告)号：EP2029547B1
公开(公告)日：2010-04-28
申请号：EP07797648.8
申请日：2007-05-22
Applicant: ELI LILLY AND COMPANY
Inventor： BELL, Michael, Gregory , DOTI, Robert, Anthony , GENIN, Michael, James , LANDER, Peter, Ambrose , MA, Tianwei , MANNINEN, Peter, Rudolph , OCHOADA, Jason, Matthew , QU, Fucheng , STELZER, Lindsay, Scott , STITES, Ryan, Edward , WARSHAWSKY, Alan, M.
IPC: C07D231/12 , C07D401/12 , C07D403/12 , C07D417/12 , A61P3/06
CPC classification number: C07D231/12 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
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公开(公告)号：EP2029547A1
公开(公告)日：2009-03-04
申请号：EP07797648.8
申请日：2007-05-22
Applicant: ELI LILLY AND COMPANY
Inventor： BELL, Michael, Gregory , DOTI, Robert, Anthony , GENIN, Michael, James , LANDER, Peter, Ambrose , MA, Tianwei , MANNINEN, Peter, Rudolph , OCHOADA, Jason, Matthew , QU, Fucheng , STELZER, Lindsay, Scott , STITES, Ryan, Edward , WARSHAWSKY, Alan, M.
IPC: C07D231/12 , C07D401/12 , C07D403/12 , C07D417/12 , A61P3/06
CPC classification number: C07D231/12 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
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公开(公告)号：EP1597254A1
公开(公告)日：2005-11-23
申请号：EP04703558.9
申请日：2004-01-20
Applicant: ELI LILLY AND COMPANY
Inventor： BELL, Michael, Gregory , GAVARDINAS, Konstantinos , GERNERT, Douglas, Linn , GRESE, Timothy, Alan , JADHAV, Prabhakar, Kondaji , LANDER, Peter, Ambrose , STEINBERG, Mitchell, Irvin
IPC: C07D409/06 , C07D209/10 , C07D407/06 , C07D209/08 , A61K31/404
CPC classification number: C07D401/06 , C07D209/08 , C07D209/10 , C07D333/56 , C07D333/68 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D491/04 , C07F5/003 , C07F5/069 , C07F7/0836
Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.
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公开(公告)号：EP2029558B1
公开(公告)日：2010-03-10
申请号：EP07811915.3
申请日：2007-05-22
Applicant: ELI LILLY AND COMPANY
Inventor： BELL, Michael, Gregory , DOTI, Robert, Anthony , DOWLING, Matthew, Scott , GENIN, Michael, James , LANDER, Peter, Ambrose , MA, Tianwei , MANTLO, Nathan, Bryan , OCHOADA, Jason, Matthew , STELZER, Lindsay, Scott , STITES, Ryan, Edward , WARSHAWSKY, Alan, M
IPC: C07D249/12 , C07D401/12 , C07D403/12 , C07D409/12 , A61K31/4192 , A61P3/06
CPC classification number: C07D249/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
Abstract: Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
Abstract translation: 其中变量如本文所定义的式（I）化合物及其药物组合物和使用方法公开可用于治疗血脂异常和相关疾病。
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公开(公告)号：EP2029558A2
公开(公告)日：2009-03-04
申请号：EP07811915.3
申请日：2007-05-22
Applicant: ELI LILLY AND COMPANY
Inventor： BELL, Michael, Gregory , DOTI, Robert, Anthony , DOWLING, Matthew, Scott , GENIN, Michael, James , LANDER, Peter, Ambrose , MA, Tianwei , MANTLO, Nathan, Bryan , OCHOADA, Jason, Matthew , STELZER, Lindsay, Scott , STITES, Ryan, Edward , WARSHAWSKY, Alan, M
IPC: C07D249/12 , C07D401/12 , C07D403/12 , C07D409/12 , A61K31/4192 , A61P3/06
CPC classification number: C07D249/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
Abstract: Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
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公开(公告)号：EP1385852B1
公开(公告)日：2005-07-20
申请号：EP02719126.1
申请日：2002-03-27
Applicant: ELI LILLY AND COMPANY
Inventor： LANDER, Peter, Ambrose , LOHMAN, Mark, Christopher
IPC: C07D498/14 , A61K31/44 , A61P35/00
CPC classification number: C07D498/04
Abstract: The present invention relates to a compound of formula (I) which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
