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公开(公告)号：EP2182950B8
公开(公告)日：2017-08-23
申请号：EP08750626.7
申请日：2008-05-16
Applicant: Helperby Therapeutics Limited
Inventor： BESWICK, Mandy, Christine , CRAMP, Susan, Mary , HU, Yanmin , PALLIN, Thomas, David , DYKE, Hazel, Joan , COATES, Anthony
IPC: A61K31/4709 , A61K31/517 , A61P31/04
CPC classification number: A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/517 , C07D401/04 , C07D403/14 , Y02A50/401 , Y02A50/404 , Y02A50/406 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/479 , Y02A50/481 , Y02A50/483
Abstract: There is provided the use of compounds of formula wherein R1, R2, R3 and E have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula (I) per se.
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公开(公告)号：EP2086542A1
公开(公告)日：2009-08-12
申请号：EP07824501.6
申请日：2007-11-08
Applicant: Helperby Therapeutics Limited
Inventor： BECK, Petra Helga , BROWN, Marc Barry , COATES, Anthony , HU, Yanmin , STODDART, Gerlinda
IPC: A61K31/4439 , C07D471/04
CPC classification number: A61K31/4353 , A61K9/0014 , C07D471/04 , Y02A50/409
Abstract: There is provided topical pharmaceutical compositions comprising compounds of formula I wherein R1, R2, R3 and X have meanings given in the description. These compositions can be used to treat microbial infections and to kill clinically latent microorganisms.
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公开(公告)号：EP3787622A1
公开(公告)日：2021-03-10
申请号：EP19718838.6
申请日：2019-04-12
Applicant: Helperby Therapeutics Limited
Inventor： COATES, Anthony , HU, Yanmin
IPC: A61K31/4178 , A61K31/431 , A61K31/545 , A61K31/55 , A61K31/665 , A61K31/7072 , A61P31/00
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公开(公告)号：EP3522875A1
公开(公告)日：2019-08-14
申请号：EP17794036.8
申请日：2017-10-05
Applicant: Helperby Therapeutics Limited
Inventor： COATES, Anthony , HU, Yanmin
IPC: A61K31/055 , A61K31/198 , A61K31/382 , A61K31/397 , A61K31/403 , A61K31/496 , A61K45/06 , A61P31/04
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公开(公告)号：EP3484587A1
公开(公告)日：2019-05-22
申请号：EP17743070.9
申请日：2017-07-11
Applicant: Helperby Therapeutics Limited
Inventor： COATES, Anthony , HU, Yanmin
IPC: A61P31/00 , A61P31/06 , A61K31/407 , A61K31/7072
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公开(公告)号：EP3099298B1
公开(公告)日：2019-03-20
申请号：EP15704827.3
申请日：2015-01-29
Applicant: Helperby Therapeutics Limited
Inventor： COATES, Anthony , HU, Yanmin
IPC: A61K31/435 , A61K31/4525 , A61K31/496 , A61K31/7072 , A61K38/12 , A61P31/04 , A61P31/10
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公开(公告)号：EP3368031A1
公开(公告)日：2018-09-05
申请号：EP16788558.1
申请日：2016-10-20
Applicant: Helperby Therapeutics Limited
Inventor： COATES, Anthony , HU, Yanmin
IPC: A61K31/351 , A61K31/736 , A61P31/00 , A61K31/4745 , A61K31/7036
CPC classification number: A61K31/4745 , A61K9/0014 , A61K9/0053 , A61K9/0073 , A61K31/351 , A61K31/7036 , A61K2300/00 , A61P31/06 , A61P31/08 , Y02A50/401 , Y02A50/404 , Y02A50/406 , Y02A50/469 , Y02A50/475 , Y02A50/479 , Y02A50/481 , Y02A50/483
Abstract: The invention provides a combination comprising 4-methyl-8-phenoxy-1-(2-phenylethyl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinoline or a pharmaceutically acceptable derivative thereof, mupirocin or a pharmaceutically acceptable derivative thereof and neomycin or a pharmaceutically acceptable derivative thereof. This triple combination is particularly useful for the treatment and/or prevention of microbial infections.
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8.发明公开ANTIMICROBIAL COMBINATIONS AND THEIR USE IN THE TREATMENT OF MICROBIAL INFECTION 审中-公开抗微生物组合及其在微生物感染治疗中的应用
公开(公告)号：EP3233069A1
公开(公告)日：2017-10-25
申请号：EP15819850.7
申请日：2015-12-18
Applicant: Helperby Therapeutics Limited
Inventor： COATES, Anthony , HU, Yanmin
IPC: A61K31/05 , A61K31/12 , A61K31/4525 , A61K31/7036 , A61P31/04
CPC classification number: A61K31/05 , A61K31/12 , A61K31/4525 , A61K31/7036 , Y02A50/401 , Y02A50/404 , Y02A50/406 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/479 , Y02A50/481 , Y02A50/483 , A61K2300/00
Abstract: The present invention relates to the use of one or more compounds selected from the following: carvacrol, thymol, curcumin and piperidine, in combination with an aminoglycoside, for use in the treatment of a microbial infection, and in particular for killing clinically latent microorganisms associated with microbial infections. The present invention also relates to novel combinations comprising one or more compounds selected from the following: carvacrol, thymol, curcumin and piperidine, in combination with an aminoglycoside, for use in the treatment of microbial infections.
Abstract translation: 本发明涉及选自以下的一种或多种化合物的用途：香芹酚，百里酚，姜黄素和哌啶与氨基糖苷类的组合，用于治疗微生物感染，特别是用于杀死与临床相关的潜在微生物 与微生物感染。 本发明还涉及包含一种或多种选自以下的化合物的新组合物：香芹酚，百里酚，姜黄素和哌啶与氨基糖苷类的组合，用于治疗微生物感染。
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9.发明公开USE OF 4-(PYRROLIDIN-1-YL)QUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS 有权用4-（吡咯烷-1-基）喹啉化合物用于临床上潜伏微生物销毁
公开(公告)号：EP2182950A1
公开(公告)日：2010-05-12
申请号：EP08750626.7
申请日：2008-05-16
Applicant: Helperby Therapeutics Limited
Inventor： BESWICK, Mandy, Christine , CRAMP, Susan, Mary , HU, Yanmin , PALLIN, Thomas, David , DYKE, Hazel, Joan , COATES, Anthony
IPC: A61K31/4709 , A61K31/517 , A61P31/04
CPC classification number: A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/517 , C07D401/04 , C07D403/14 , Y02A50/401 , Y02A50/404 , Y02A50/406 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/479 , Y02A50/481 , Y02A50/483
Abstract: There is provided the use of compounds of formula wherein R1, R2, R3 and E have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula (I) per se.
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公开(公告)号：EP4028022A1
公开(公告)日：2022-07-20
申请号：EP20772392.5
申请日：2020-09-10
Applicant: Helperby Therapeutics Limited
Inventor： COATES, Anthony , HU, Yanmin
IPC: A61K31/7072 , A61K31/4709 , A61K31/496 , A61K31/5383 , A61K45/06 , A61P31/04
