公开(公告)号：EP3042607A1

公开(公告)日：2016-07-13

申请号：EP15150843.9

申请日：2015-01-12

申请人： Stichting IMEC Nederland ,  IMEC VZW

发明人： Xu, Jiawei ,  Yazicioglu, Refet Firat

IPC分类号： A61B5/04

CPC分类号： A61B5/04004

摘要： The invention provides a biopotential signal acquisition system, comprising at least two active electrodes (10,16) each for receiving a signal from an input, for example in the form of a respective patient contact. A unity gain buffer (32) is used to feed forward a signal from an associated input and provide the buffered output to the amplifiers of the active electrodes as a reference signal. The buffered signal is approximately equal to the input common mode signal so that the effective common mode input voltage appearing at the inputs of each amplifier is significantly reduced. This reduces the common mode gain of the active electrodes and thus improves their common mode rejection ratio while also avoiding saturation of the active electrodes.

摘要翻译： 本发明提供了一种生物电势信号采集系统，其包括至少两个有源电极（10,16），每个用于从输入端接收信号，例如以相应的患者接触的形式。 单位增益缓冲器（32）用于从相关联的输入端提供信号，并将缓冲的输出提供给有源电极的放大器作为参考信号。 缓冲信号近似等于输入共模信号，从而显着降低出现在每个放大器输入端的有效共模输入电压。 这降低了有源电极的共模增益，从而提高了它们的共模抑制比，同时也避免了有源电极的饱和。

公开(公告)号：EP2442443B8

公开(公告)日：2018-02-07

申请号：EP11155072.9

申请日：2011-02-18

申请人： IMEC VZW ,  Stichting IMEC Nederland

发明人： Xu, Jiawei ,  Yazicioglu, Refet Firat

IPC分类号： H03F3/45 ,  A61B5/04 ,  A61B5/0428

CPC分类号： A61B5/04004 ,  A61B5/0428 ,  H03F3/45475 ,  H03F3/45928 ,  H03F2200/261 ,  H03F2203/45138

摘要： Described herein is a multi-channel biopotential signal acquisition system (900) in which a plurality of biopotential channels is corrected for common-mode interference. Each biopotential channel comprises an electrode (910, 920, 930, 940) for providing a biopotential input signal and an associated amplifier (950, 960, 970, 980) for amplifying the biopotential input signal and for providing a biopotential output signal (955, 965, 975, 985) that is processed in a processor (250, 260, 270, 990). Each biopotential output signal (955, 965, 975, 985) is passed to a common-mode feedback system (810) that determines an average common-mode signal and feeds that signal back to each of the amplifiers (950, 960, 970, 980) in each of the biopotential channels to enhance common-mode rejection ratio of the system (900).

公开(公告)号：EP2818103B1

公开(公告)日：2016-08-03

申请号：EP13173917.9

申请日：2013-06-27

申请人： IMEC ,  Stichting IMEC Nederland

发明人： Xu, Jiawei ,  Yazicioglu, Refet Firat

IPC分类号： A61B5/04 ,  A61B5/0428 ,  A61B5/0492 ,  A61B5/0408 ,  A61B5/0478 ,  H03F3/45

CPC分类号： A61B5/7207 ,  A61B5/04004 ,  A61B5/0402 ,  A61B5/0408 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/0496 ,  A61B2562/0209

摘要： A biopotential signal acquisition system comprises: a first active electrode (10) comprising an integrated pre-amplifier (12) and an analogue to digital converter (14); a second active electrode (16) comprising an integrated preamplifier (18) and an analogue to digital converter (20), wherein the second active electrode has variable gain; a test signal generator (38) for generating a test signal at a test frequency and coupling the test signal to the first and/or second active electrodes (10,16); and a digital signal processor (30) adapted to: process the digital outputs (Vout_ref, Vout1) of the first and second active electrodes (10,16) to derive a gain control signal (D1) based on a difference between the first and second active electrode outputs (Vout_ref, Vout1) at the test frequency, and apply the gain control signal (D1) to the second active electrode (16).

公开(公告)号：EP2442443A1

公开(公告)日：2012-04-18

申请号：EP11155072.9

申请日：2011-02-18

申请人： IMEC ,  Stichting IMEC Nederland

发明人： Xu, Jiawei ,  Yazicioglu, Refet Firat

IPC分类号： H03F3/45 ,  A61B5/04 ,  A61B5/0428

CPC分类号： A61B5/04004 ,  A61B5/0428 ,  H03F3/45475 ,  H03F3/45928 ,  H03F2200/261 ,  H03F2203/45138

摘要： Described herein is a multi-channel biopotential signal acquisition system (900) in which a plurality of biopotential channels is corrected for common-mode interference. Each biopotential channel comprises an electrode (910, 920, 930, 940) for providing a biopotential input signal and an associated amplifier (950, 960, 970, 980) for amplifying the biopotential input signal and for providing a biopotential output signal (955, 965, 975, 985) that is processed in a processor (250, 260, 270, 990). Each biopotential output signal (955, 965, 975, 985) is passed to a common-mode feedback system (810) that determines an average common-mode signal and feeds that signal back to each of the amplifiers (950, 960, 970, 980) in each of the biopotential channels to enhance common-mode rejection ratio of the system (900).

摘要翻译： 这里描述的是多通道生物电位信号采集系统（900），其中多个生物电位通道被校正为共模干扰。 每个生物电位通道包括用于提供生物电位输入信号的电极（910,920,930,940）和用于放大生物电位输入信号的相关放大器（950,960,970,980），并提供生物电位输出信号（955， 965,975,985），其在处理器（250,260,270,990）中处理。 每个生物电势输出信号（955,965,975,985）被传递到共模反馈系统（810），该共模反馈系统确定平均共模信号，并将该信号反馈给每个放大器（950,960,970,985,985,985,985,985） 980），以增强系统的共模抑制比（900）。

公开(公告)号：EP2442443B1

公开(公告)日：2017-12-13

申请号：EP11155072.9

申请日：2011-02-18

申请人： IMEC ,  Stichting IMEC Nederland

发明人： Xu, Jiawei ,  Yazicioglu, Refet Firat

IPC分类号： H03F3/45 ,  A61B5/04 ,  A61B5/0428

CPC分类号： A61B5/04004 ,  A61B5/0428 ,  H03F3/45475 ,  H03F3/45928 ,  H03F2200/261 ,  H03F2203/45138

摘要： Described herein is a multi-channel biopotential signal acquisition system (900) in which a plurality of biopotential channels is corrected for common-mode interference. Each biopotential channel comprises an electrode (910, 920, 930, 940) for providing a biopotential input signal and an associated amplifier (950, 960, 970, 980) for amplifying the biopotential input signal and for providing a biopotential output signal (955, 965, 975, 985) that is processed in a processor (250, 260, 270, 990). Each biopotential output signal (955, 965, 975, 985) is passed to a common-mode feedback system (810) that determines an average common-mode signal and feeds that signal back to each of the amplifiers (950, 960, 970, 980) in each of the biopotential channels to enhance common-mode rejection ratio of the system (900).

公开(公告)号：EP2818103A1

公开(公告)日：2014-12-31

申请号：EP13173917.9

申请日：2013-06-27

申请人： IMEC ,  Stichting IMEC Nederland

发明人： Xu, Jiawei ,  Yazicioglu, Refet Firat

IPC分类号： A61B5/04 ,  A61B5/0428 ,  A61B5/0492 ,  A61B5/0408 ,  A61B5/0478 ,  H03F3/45

CPC分类号： A61B5/7207 ,  A61B5/04004 ,  A61B5/0402 ,  A61B5/0408 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/0496 ,  A61B2562/0209

摘要： A biopotential signal acquisition system comprises: a first active electrode (10) comprising an integrated pre-amplifier (12) and an analogue to digital converter (14); a second active electrode (16) comprising an integrated preamplifier (18) and an analogue to digital converter (20), wherein the second active electrode has variable gain; a test signal generator (38) for generating a test signal at a test frequency and coupling the test signal to the first and/or second active electrodes (10,16); and a digital signal processor (30) adapted to: process the digital outputs (Vout_ref, Vout1) of the first and second active electrodes (10,16) to derive a gain control signal (D1) based on a difference between the first and second active electrode outputs (Vout_ref, Vout1) at the test frequency, and apply the gain control signal (D1) to the second active electrode (16).

摘要翻译： 生物电位信号采集系统包括：包括集成前置放大器（12）和模数转换器（14）的第一有源电极（10）; 包括集成前置放大器（18）和模数转换器（20）的第二有源电极（16），其中所述第二有源电极具有可变增益; 测试信号发生器（38），用于在测试频率处产生测试信号，并将测试信号耦合到第一和/或第二有源电极（10,16）; 以及数字信号处理器（30），其适于：处理所述第一和第二有源电极（10,16）的数字输出（Vout_ref，Vout1），以基于所述第一和第二有源电极之间的差导出增益控制信号（D1） 在测试频率处的有源电极输出（Vout_ref，Vout1），并将增益控制信号（D1）施加到第二有源电极（16）。

公开(公告)号：EP3909503A1

公开(公告)日：2021-11-17

申请号：EP20174008.1

申请日：2020-05-12

申请人： Stichting IMEC Nederland

发明人： Xu, Jiawei ,  Mihajlovic, Vojkan

IPC分类号： A61B5/04 ,  A61B5/0478 ,  A61B5/00

摘要： An electrode (10) for potential acquisition of a surface is provided. The electrode (10) comprises at least two pins (11a, 11b, 21) for contacting the surface, and a local signal processing unit (12) connected to at least one (11a, 11b) of the pins (11a, 11b, 21). The local signal processing unit (12) is configured to perform signal processing operations with respect to the corresponding surface potential signal of the respective at least one pin (11a, 11b). In addition to this, the local signal processing unit (12) is directly integrated into the electrode (10).

公开(公告)号：EP3141898B1

公开(公告)日：2020-02-05

申请号：EP16188313.7

申请日：2016-09-12

申请人： Stichting IMEC Nederland

发明人： Xu, Jiawei ,  Harpe, Pieter

IPC分类号： G01N33/483 ,  G01N27/02 ,  A61B5/0428 ,  A61B5/053

公开(公告)号：EP3141898A1

公开(公告)日：2017-03-15

申请号：EP16188313.7

申请日：2016-09-12

申请人： Stichting IMEC Nederland

发明人： Xu, Jiawei ,  Harpe, Pieter

IPC分类号： G01N33/483 ,  A61B5/053 ,  G01N27/02

CPC分类号： A61B5/7278 ,  A61B5/0205 ,  A61B5/0402 ,  A61B5/0428 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/7225 ,  A61B5/725 ,  A61B5/7257 ,  G01N27/026 ,  G01N33/4836

摘要： An impedance spectroscopy system is provided for bio-impedance measurement in which a signal is generated with a broadband frequency spectrum, and an analog injection current is derived from the signal, wherein the analog injection current has a high pass frequency characteristic. An amplifier is used for measuring a voltage in response to the analog injection signal, but also containing biopotential information (e.g., ECG or EEG), from which a bio-impedance spectrum as well as other parameters may be obtained.
This system makes use of an injection current with a high pass frequency characteristic so that the injection current increases with frequency. This compensates for the typical bio-impedance behavior so that the signal to noise ratio of the system is more uniform over frequency.

摘要翻译： 提供用于生物阻抗测量的阻抗谱系统，其中用宽带频谱生成信号，并且从该信号导出模拟注入电流，其中模拟注入电流具有高通频率特性。 放大器用于响应于模拟注入信号测量电压，但也包含生物电位信息（例如ECG或EEG），从中可以获得生物阻抗谱以及其他参数。 该系统利用具有高通频率特性的注入电流，使注入电流随频率增加。 这补偿了典型的生物阻抗行为，使得系统的信噪比在整个频率上更均匀。