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公开(公告)号：EP3102198B1
公开(公告)日：2020-08-26
申请号：EP15745823.3
申请日：2015-02-03
Applicant: Merck Sharp & Dohme Corp.
Inventor： CHOBANIAN, Harry , DEMONG, Duane , GUO, Yan , HU, Zhiyong , MILLER, Michael , PIO, Barbara , PLUMMER, Christopher, W. , XIAO, Dong , YANG, Cangming , ZHANG, Rui
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2.发明公开
公开(公告)号：EP3978472A1
公开(公告)日：2022-04-06
申请号：EP21204101.6
申请日：2016-12-12
Applicant: MERCK SHARP & DOHME CORP.
Inventor： TANG, Haifeng , LIU, Weiguo , DING, Fa-Xiang , SUN, Wanying , ZANG, Yi , PAN, Weidong , OGAWA, Anthony , BROCKUNIER, Linda , HUANG, Xianhai , WANG, Hongwu , MAL, Rudrajit , BIFTU, Tesfaye , PARK, Min , GUO, Yan , JIANG, Jinlong , CHEN, Helen , PLUMMER, Christopher, W.
IPC: C07D205/08 , A61K31/397 , A61P31/04 , C07F9/6558 , C07C53/18
Abstract: The present invention relates to biaryl monobactam compounds of Formula I:
and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A 1 , Q, A 2 , M, W, R X and R z are as defined herein. The present invention also relates to compositions which comprise a biaryl monobactam compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.
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公开(公告)号：EP3887377A1
公开(公告)日：2021-10-06
申请号：EP19888675.6
申请日：2019-11-26
Applicant: Merck Sharp & Dohme Corp.
Inventor： ZHANG, Yonglian , ALI, Amjad , CUMMING, Jared , DEMONG, Duane , DENG, Qiaolin , GRAHAM, Thomas, H. , HENNESSY, Elisabeth , LARSEN, Matthew, A. , LIU, Kun , LIU, Ping , MANSOOR, Umar Faruk , PAN, Jianping , PLUMMER, Christopher, W. , SATHER, Aaron , SWAMINATHAN, Uma , WANG, Huijun
IPC: C07D487/04 , C07D487/08 , C07D487/18
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公开(公告)号：EP3886988A1
公开(公告)日：2021-10-06
申请号：EP19827893.9
申请日：2019-11-26
Applicant: Merck Sharp & Dohme Corp.
Inventor： LARSEN, Matthew, A. , ALI, Amjad , CUMMING, Jared , DEMONG, Duane , DENG, Qiaolin , GRAHAM, Thomas, H. , HENNESSY, Elisabeth , HOOVER, Andrew, J. , LIU, Ping , LIU, Kun , MANSOOR, Umar Faruk , PAN, Jianping , PLUMMER, Christopher, W. , SATHER, Aaron , SWAMINATHAN, Uma , WANG, Huijun , ZHANG, Yonglian
IPC: A61P35/00 , C07D487/04 , A61K31/519
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公开(公告)号：EP3177285A1
公开(公告)日：2017-06-14
申请号：EP15829495.9
申请日：2015-08-03
Applicant: Merck Sharp & Dohme Corp.
Inventor： CHEN, Helen, Y. , DEMONG, Duane , FINKE, Paul, E. , PLUMMER, Christopher, W.
IPC: A61K31/343 , A61K31/443 , C07D307/79
CPC classification number: C07D405/04 , A61K31/343 , A61K31/443 , A61K45/06 , C07D307/80 , C07D405/10 , A61K2300/00
Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
Abstract translation: 结构式（I）的新型化合物及其药学上可接受的盐是G蛋白偶联受体40（GPR40）的激动剂，可用于治疗，预防和抑制G蛋白偶联受体 受体40.本发明的化合物可用于治疗2型糖尿病，以及通常与该疾病相关的病症，包括肥胖症和脂质疾病，例如混合或糖尿病性血脂异常，高脂血症，高胆固醇血症和 高甘油三酯血症。
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公开(公告)号：EP3883575A1
公开(公告)日：2021-09-29
申请号：EP19886307.8
申请日：2019-11-15
Applicant: Merck Sharp & Dohme Corp.
Inventor： BRILL, Zachary, G. , ALI, Amjad , CUMMING, Jared , DEMONG, Duane , DENG, Qiaolin , GRAHAM, Thomas, H. , KUANG, Rongze , LIM, Yeon-Hee , PLUMMER, Christopher, W. , RICO DUQUE, Jenny Lorena , WANG, Huijun , ZHANG, Yonglian , ZHAO, Kake
IPC: A61K31/519 , A61P35/00 , C07D487/04
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公开(公告)号：EP3177282A1
公开(公告)日：2017-06-14
申请号：EP15829663.2
申请日：2015-08-03
Applicant: Merck Sharp & Dohme Corp.
Inventor： CHOBANIAN, Harry , DEMONG, Duane , GUO, Yan , PIO, Barbara , PLUMMER, Christopher, W.
IPC: A61K31/192 , A61K31/353 , C07D311/20
CPC classification number: C07D335/06 , A61K31/192 , A61K31/352 , A61K31/353 , A61K31/366 , A61K31/382 , A61K31/44 , A61K31/444 , A61K31/453 , A61K45/06 , C07D213/64 , C07D311/04 , C07D311/20 , C07D405/04 , C07D405/10 , A61K2300/00
Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
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公开(公告)号：EP2880028B1
公开(公告)日：2020-09-30
申请号：EP13750427.0
申请日：2013-07-31
Applicant: Merck Sharp & Dohme Corp.
Inventor： HAGMANN, William, K. , NARGUND, Ravi, P. , BLIZZARD, Timothy, A. , JOSIEN, Hubert , BIJU, Purakkattle , PLUMMER, Christopher, W. , DANG, Qun , LI, Bing , LIN, Linus, S. , CUI, Mingxiang , HU, Bin , HAO, Jinglai , CHEN, Zhengxia
IPC: C07D401/14 , C07D221/16 , C07D401/12 , C07F9/40 , A61K31/435 , A61P3/04 , A61P3/06 , A61P3/10
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公开(公告)号：EP3177285B1
公开(公告)日：2020-09-23
申请号：EP15829495.9
申请日：2015-08-03
Applicant: Merck Sharp & Dohme Corp.
Inventor： CHEN, Helen, Y. , DEMONG, Duane , FINKE, Paul, E. , PLUMMER, Christopher, W.
IPC: A61K31/343 , A61K31/443 , C07D307/80 , C07D405/04 , C07D405/10
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公开(公告)号：EP3463362A1
公开(公告)日：2019-04-10
申请号：EP17803324.7
申请日：2017-05-19
Applicant: Merck Sharp & Dohme Corp.
Inventor： ADAMS, Gregory, L. , COX, Jason, M. , DEBENHAM, John, S. , EDMONDSON, Scott , GILBERT, Eric, J. , GUO, Yan , JIANG, Yu , JOSIEN, Hubert , KIM, Hyunjin, M. , LAN, Ping , MIAO, Shouwu , PLUMMER, Christopher, W. , RAJAGOPALAN, Murali , SHAH, Unmesh , SUN, Zhongxiang , TRUONG, Quang, T. , UJJAINWALLA, Feroze , VELAZQUEZ, Francisco , VENKATRAMAN, Srikanth , SUZUKI, Takao , WANG, Nengxue
IPC: A61K31/472 , A61K31/4725 , A61P3/10 , C07D217/02
