公开(公告)号：EP1052990A2

公开(公告)日：2000-11-22

申请号：EP98955387.0

申请日：1998-11-13

Applicant: NEUROSEARCH A/S

Inventor： OLESEN, S ren-Peter ,  JENSEN, Bo, Skaaning ,  J RGENSEN, Tino, Dyhring ,  STR B K, Dorte ,  CHRISTOPHERSEN, Palle ,  ODUM, Niels

IPC: A61K31/44 ,  A61K31/415 ,  G01N33/566

CPC classification number: G01N33/6872 ,  A61K31/4422 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/5064 ,  Y02A50/409

Abstract: This invention relates to treatment or alleviation of a disease, condition or disorder selected from inflammatory bowel disease, Chron's disease, colitis ulcerosa, Coeliac disease, dermatitis herpetiformis, dermatomyositis, enteritis allergia, erytherma nodosum leprosum, ileitis regionalis, psoriasis, purpura, scleritis or scleroderma by administering to a living body certain imidazole, triazole, or 1,4-dihydropyridine derivatives.

公开(公告)号：EP1091942A1

公开(公告)日：2001-04-18

申请号：EP99931019.6

申请日：1999-07-01

Applicant: NEUROSEARCH A/S

Inventor： TEUBER, Lene ,  OLESEN, S ren-Peter ,  STR B K, Dorte ,  JENSEN, Bo, Skaaning ,  PETERS, Dan

IPC: C07D235/30 ,  C07D417/04 ,  C07D403/10 ,  C07D417/12 ,  C07D219/08 ,  C07D255/04 ,  C07D239/42 ,  C07D487/18 ,  C07D235/20 ,  C07D279/18 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/395 ,  A61K31/505 ,  A61K31/155

CPC classification number: C07D235/24 ,  C07C279/18 ,  C07D219/08 ,  C07D235/20 ,  C07D235/30 ,  C07D239/42 ,  C07D255/04 ,  C07D403/10 ,  C07D417/04 ,  C07D417/12

Abstract: This invention relates to novel potassium channel blocking agents, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, in particular asthma, cystic fibrosis, chronic obstructive pulmonary disease and rhinorrhea, convulsions, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, irritable bowel syndrome, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, traumatic brain injury, psychosis, anxiety, depression, dementia, memory and attention deficits, Alzheimer's disease, dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, migraine, arrhythmia, hypertension, absence seizures, myotonic muscle dystrophia, xerostomi, diabetes type II, hyperinsulinemia, premature labour, baldness, cancer, and immune suppression.

公开(公告)号：EP1187610A2

公开(公告)日：2002-03-20

申请号：EP00926722.0

申请日：2000-05-12

Applicant: NEUROSEARCH A/S

Inventor： JENSEN, Bo, Skaaning ,  TEUBER, Lene ,  STR B K, Dorte ,  CHRISTOPHERSEN, Palle ,  OLESEN, S ren, Peter

IPC: A61K31/403 ,  A61K31/404 ,  A61K31/55

CPC classification number: A61K45/06 ,  A61K31/122 ,  A61K31/15 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/55 ,  Y02A50/409

Abstract: The present invention relates to the use of a particular class of chemical compounds as modulators of SKCa, IKCa and BKCa channels, and to pharmaceutical compositions comprising the SK/IK/BK channel modulating agents.

公开(公告)号：EP1091942B1

公开(公告)日：2005-03-30

申请号：EP99931019.6

申请日：1999-07-01

Applicant: NEUROSEARCH A/S

Inventor： TEUBER, Lene ,  OLESEN, S ren-Peter ,  STR B K, Dorte ,  JENSEN, Bo, Skaaning ,  PETERS, Dan

IPC: C07D235/30 ,  C07D417/04 ,  C07D403/10 ,  C07D417/12 ,  C07D219/08 ,  C07D255/04 ,  C07D239/42 ,  C07D487/18 ,  C07D235/20 ,  C07D279/18 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/395 ,  A61K31/505 ,  A61K31/155

CPC classification number: C07D235/24 ,  C07C279/18 ,  C07D219/08 ,  C07D235/20 ,  C07D235/30 ,  C07D239/42 ,  C07D255/04 ,  C07D403/10 ,  C07D417/04 ,  C07D417/12

公开(公告)号：EP1178963A1

公开(公告)日：2002-02-13

申请号：EP00926720.4

申请日：2000-05-12

Applicant: NEUROSEARCH A/S

Inventor： JENSEN, Bo, Skaaning ,  TEUBER, Lene ,  STR B K, Dorte ,  CHRISTOPHERSEN, Palle ,  OLESEN, S ren, Peter

IPC: C07D213/04 ,  C07D207/32 ,  C07D233/56 ,  C07C205/06 ,  C07C233/07 ,  C07C25/02 ,  A61K31/435 ,  A61K31/40 ,  A61K31/4164 ,  A61K31/167 ,  A61K31/05

CPC classification number: C07C25/02 ,  A61K31/05 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4164 ,  A61K31/435 ,  C07C205/22 ,  C07C233/15 ,  C07D207/32 ,  C07D213/04 ,  C07D233/56

Abstract: The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds represented by general Formula (I) and a pharmaceutically acceptable salt or an oxide or a hydrate thereof, that has proven useful as modulators of SKCa, IKCa and BKCa channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.