公开(公告)号：EP1406613B1

公开(公告)日：2007-11-28

申请号：EP02747327.1

申请日：2002-05-28

Applicant: NicOx S.A.

Inventor： DEL SOLDATO, Piero

IPC: A61K31/40 ,  A61K31/60 ,  A61K31/621 ,  A61P1/00 ,  A61P7/12 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/28 ,  A61P43/00

CPC classification number: A61K31/618 ,  A61K31/603 ,  A61K31/621 ,  A61K31/625

Abstract: Use for the vasculopathy treatment of compounds or salts thereof, having the following general formula: A-(B)b0-(C)c0-NO2 wherein A is the radical of the precursor drug selected between the salicylic or acetylsalicylic acid, B and C are bivalent linking groups as defined in the invention.

公开(公告)号：EP1691804B1

公开(公告)日：2007-04-04

申请号：EP04803434.2

申请日：2004-12-01

Applicant: NicOx S.A.

Inventor： DEL SOLDATO, Piero ,  BENEDINI, Francesca ,  ONGINI, Ennio

IPC: A61K31/403 ,  C07D209/88 ,  C07C203/04 ,  A61P9/12

CPC classification number: C07C219/14 ,  C07C219/06 ,  C07C233/33 ,  C07C235/08 ,  C07C235/42 ,  C07C311/08 ,  C07C2601/08 ,  C07C2602/10 ,  C07D209/88

Abstract: The present invention relates to β-adrenergic blockers nitrooxyderivatives of general formula (I): A-(Y-ONO2)s, wherein s is an integer equal to 1 or 2; A is selected from the following β-adrenergic blockers residues of formula (II), wherein R1 is selected from the group consisting of: formula (IIa), formula (IIb), formula (IIc) or other residues defined in claim 1; R2 is selected from the group consisting of: -CH(CH3)2, -C(CH3)3 or formula (IIIa), formula (IIIb), Z is H or is a group capable of binding Y as defined in claim 1, Z1 is H or a -C(O)- capable of binding Y; the other substituents are defined in claim 1; and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and their use for the treatment of hypertension, cardiovascular diseases, glaucoma, migraine headache and vascular diseases.

Abstract translation: 本发明涉及通式（I）：A-（Y-ONO 2）s及其对映异构体和非对映异构体及其药学上可接受的盐，其含有它们的药物组合物及其用于治疗高血压，心血管的用途的β-肾上腺素能阻断剂 疾病，青光眼，偏头痛和血管疾病。

公开(公告)号：EP1526839B1

公开(公告)日：2007-03-14

申请号：EP03760660.5

申请日：2003-06-20

Applicant: NicOx S.A.

Inventor： DEL SOLDATO, Piero ,  SANTUS, Giancarlo ,  MACELLONI, Cristina

IPC: A61K9/107 ,  A61K31/216 ,  A61K31/235 ,  A61K31/407 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4164 ,  A61K31/4709

CPC classification number: A61K9/145 ,  A61K9/1075 ,  A61K9/143 ,  A61K31/216 ,  A61K31/235 ,  A61K31/407 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4709 ,  A61K2300/00

Abstract: The present invention relates to new pharmaceutical compositions for the administration of liquid drugs in solid oral forms, said compositions comprising one or more active ingredients, one or more surface-active agents and optionally a co-surfactant and/or an absorption enhancer absorbed on a solid inert carrier.

公开(公告)号：EP1626716B1

公开(公告)日：2007-02-07

申请号：EP04741636.7

申请日：2004-05-24

Applicant: NicOx S.A.

Inventor： BENEDINI, Francesca ,  ONGINI, Ennio ,  DEL SOLDATO, Piero

IPC: A61K31/405 ,  A61K31/40 ,  C07D209/26 ,  C07D207/34 ,  A61P3/06

CPC classification number: C07D207/34 ,  C07D209/24 ,  C07D213/55 ,  C07D239/42

Abstract: Nitrooxyderivatives of fluvastatin, cerivastatin, atorvastatin and rosuvastatin having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.

公开(公告)号：EP1347744B1

公开(公告)日：2004-09-08

申请号：EP01995695.2

申请日：2001-12-18

Applicant: Nicox S.A.

Inventor： TRESPIDI, Laura ,  DEL SOLDATO, Piero

IPC: A61K9/14

CPC classification number: A61K9/146

公开(公告)号：EP0931065B1

公开(公告)日：2004-07-28

申请号：EP97919021.2

申请日：1997-09-02

Applicant: Nicox S.A.

Inventor： DEL SOLDATO, Piero ,  SANNICOLO', Francesco

IPC: A61K31/00 ,  A61P13/00

CPC classification number: A61K31/00 ,  A61K31/21 ,  A61K31/216 ,  A61K31/245 ,  A61K31/405 ,  C07C229/58 ,  C07C311/08 ,  C07C311/51 ,  C07D209/28

公开(公告)号：EP1253924A1

公开(公告)日：2002-11-06

申请号：EP01909631.2

申请日：2001-01-16

Applicant: NICOX S.A.

Inventor： DEL SOLDATO, Piero ,  BENEDINI, Francesca ,  ANTOGNAZZA, Patrizia

IPC: A61K31/43 ,  A61P31/10

CPC classification number: C07D215/56 ,  C07C237/26 ,  C07C2603/46 ,  C07D215/32 ,  C07D233/94 ,  C07D239/49 ,  C07D241/24 ,  C07D261/16 ,  C07D295/13 ,  C07D295/15 ,  C07D295/215 ,  C07D405/12 ,  C07D473/00 ,  C07D499/00 ,  C07D501/00 ,  C07H5/06 ,  C07H13/12 ,  C07H15/26 ,  C07H17/08

Abstract: Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.

公开(公告)号：EP1252133A2

公开(公告)日：2002-10-30

申请号：EP00953102.1

申请日：2000-07-27

Applicant: NICOX S.A.

Inventor： DEL SOLDATO, Piero

IPC: C07C219/14 ,  C07C219/30 ,  C07C229/42 ,  C07C233/25 ,  C07D219/10 ,  C07D295/08 ,  C07D309/30 ,  C07D401/12 ,  C07D471/04 ,  C07D495/04 ,  C07D499/68 ,  C07H15/252 ,  A61K31/21 ,  C07D495/00 ,  C07D333/00 ,  C07D213/00

CPC classification number: C07D295/088 ,  C07C203/04 ,  C07C219/22 ,  C07C219/24 ,  C07C229/42 ,  C07C233/25 ,  C07C317/44 ,  C07C2602/08 ,  C07D219/10 ,  C07D309/30 ,  C07D401/12 ,  C07D499/00 ,  C07F9/3873 ,  C07H15/252

Abstract: Compounds or their salts of general formula (I): A B N(O)s wherein: s is an integer equal to 1 or 2; A = R T1-, wherein R is the drug radical and T1 = (CO)t or (X)t', wherein X = O, S, NR1c, R1c is H or a linear or branched alkyl or a free valence, t and t' are integers and equal to zero or 1, with the proviso that t = 1 when t' = 0; t = 0 when t' = 1; B = -TB X2 O- wherein TB = (CO) when t = 0, TB = X when t' = 0, X being as above defined; X2, bivalent radical, is such that the precursor drug of A and the precursor of B meet respectively the pharmacological tests described in the description.

Abstract translation: 通式（I）的化合物或其盐：A B N（O）s其中：s是等于1或2的整数; A = R T1-，其中R是药物基团并且T 1 =（CO）t或（X）t'，其中X = O，S，NR 1c，R 1c是H或直链或支链烷基或自由价，t 和t'是整数并且等于零或1，条件是当t'= 0时t = 1; 当t'= 1时t = 0; B = -TB X2 O-其中当t = 0时TB =（CO），当t'= 0时TB = X，X如上所定义; X2是二价基团，使得A的前体药物和B的前体分别满足说明书中描述的药理学试验。

公开(公告)号：EP0941218B1

公开(公告)日：2002-10-16

申请号：EP97951890.9

申请日：1997-11-12

Applicant: NICOX S.A.

Inventor： DEL SOLDATO, Piero

IPC: C07D285/10 ,  C07K5/062 ,  A61K31/41 ,  A61K38/05

CPC classification number: C07D285/10 ,  A61K38/00 ,  C07C203/02 ,  C07K5/06026

公开(公告)号：EP1192129A2

公开(公告)日：2002-04-03

申请号：EP00917074.7

申请日：2000-04-11

Applicant: NICOX S.A.

Inventor： DEL SOLDATO, Piero

IPC: C07C327/34 ,  C07C69/618 ,  C07C69/65 ,  C07D207/16 ,  C07C211/49 ,  C07C219/10 ,  C07D209/28 ,  C07D233/64 ,  C07D277/06 ,  C07D277/14 ,  C07D295/088 ,  C07D309/30 ,  C07D401/12 ,  C07D407/04 ,  C07D417/12 ,  C07D473/08 ,  C07D495/04 ,  C07D499/32 ,  C07F9/38 ,  C07H15/252 ,  A61K31/16

CPC classification number: C07F9/3873 ,  C07C327/34 ,  C07C2601/14 ,  C07H17/07

Abstract: Compounds or their salts of general formula (I): A-(B) wherein A = R-T1-, wherein R is the drug radical and T1 = (CO)t or (X)t', wherein X = O, S, NR1C, R1C is H or an alkyl having from 1 to 5 carbon atoms, or a free valence, t and t' are integers and equal to zero or 1, with the proviso that t = 1 when t' = 0; t = 0 when t' = 1; B = -TB-X2 wherein TB = (CO) when t = 0, TB = X when t' = -, X being as above defined; X2, monovalent radical, is such that the precursor drug of A and the precursor of B respectively meet the pharmacological tests described in the application.

Abstract translation: 通式（I）的化合物或它们的盐：A-（B）其中A = R-T1-，其中R是药物基团并且T1 =（CO）t或（X）t'，其中X = O，S NR 1 C，R 1 C为H或具有1至5个碳原子的烷基或自由价，t和t'为整数并且等于0或1，条件是当t'= 0时t = 1; 当t'= 1时t = 0; B = -TB-X2其中当t = 0时TB =（CO），当t'= - 时TB = X，X如上所定义; X2是单价基团，使得A的前体药物和B的前体分别满足本申请中描述的药理学测试。