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公开(公告)号：EP1812441A1
公开(公告)日：2007-08-01
申请号：EP05819276.6
申请日：2005-11-10
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P17/00
CPC分类号： C07D487/04
摘要： The invention relates to 1,4-substituted pyrazolopyrimidine compounds of the formula (I), pharmaceuticals comprising a 1,4-substituted pyrazolopyrimidine compound, the use of a 1,4-substituted pyrazolopyrimidine compound in the treatment or the use thereof in the manufacture of a pharmaceutical formulation for the treatment of a disease that depends on inadequate activity of a protein kinase, methods of treatment comprising administering a 1,4-substituted pyrazolopyrimidine compound, methods for the manufacture of a novel compound of that class, and novel intermediates and partial steps for their synthesis.
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公开(公告)号：EP1778640A1
公开(公告)日：2007-05-02
申请号：EP05777531.4
申请日：2005-08-10
申请人： Novartis AG , Novartis Pharma GmbH
发明人： CARAVATTI, Giorgio , FURET, Pascal , IMBACH, Patricia , MARTINY-BARON, Georg , PEREZ, Lawrence, Blas , SHENG, Tao
IPC分类号： C07D217/02 , C07D239/74 , C07D277/62 , C07D237/30 , C07D239/84 , A61K31/472 , A61K31/428 , A61P35/00
CPC分类号： C07D277/62 , C07D217/02 , C07D237/30 , C07D239/74 , C07D239/84
摘要： The invention relates to trifluoromethyl substituted benzamide compounds of the formula (I), pharmaceuticals comprising these compounds, their use as or for the manufacture of pharmaceuticals, particularly as inhibitors of protein kinases and/or the treatment of a condition, disorder or disease state mediated by a protein kinase activity and/or a proliferative disease, methods of treatment comprising administering the compounds, especially of therapeutic and prophylactic treatment, methods for the manufacture of the compounds and novel intermediates and partial steps for their synthesis.
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3.发明公开PHENYL-(4-(3-PHENYL-1H-PYRAZOL-4-YL)-PYRIMIDIN-2-Yl)-AMINE DERIVATIVES 有权苯基 - （4-（3-苯基-1H-吡唑-4-基） - 嘧啶-2-基）胺衍生物
公开(公告)号：EP1521749A1
公开(公告)日：2005-04-13
申请号：EP03762663.7
申请日：2003-07-08
申请人： Novartis AG , Novartis Pharma GmbH
发明人： FURET, Pascal , IMBACH, Patricia , RAMSEY, Timothy, Michael , SCHLAPBACH, Achim , SCHOLZ, Dieter , CARAVATTI, Giorgio
IPC分类号： C07D403/04 , A61K31/505
CPC分类号： C07D403/04 , A61K31/505
摘要： The invention relates to phenyl-[4-(3-phenyl-1H-pyrazol-4-yl)-pyrimidin-2-yl)-amine derivatives and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives - alone or in combination with one or more other pharmaceutically active compounds - for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.
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公开(公告)号：EP1784392A2
公开(公告)日：2007-05-16
申请号：EP05776772.5
申请日：2005-08-26
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
发明人： IMBACH, Patricia , KAWAHARA, Eiji Novartis Pharma K.K. , KONISHI, Kazuhide Novartis Pharma K.K. , MATSUURA, Naoko Novartis Pharma K.K. , MIYAKE, Takahiro Novartis Pharma K.K. , OHMORI, Osamu Novartis Pharma K.K. , ROESEL, Johannes , TENO, Naoki Novartis Pharma K.K. , UMEMURA, Ichiro Novartis Pharma K.K.
IPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D413/12 , C07D403/14 , C07D401/14 , C07D498/04 , C07D409/12 , C07D409/14 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D413/12
摘要： Novel pyrimidine derivatives of formula (I) to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 式（I）的新型嘧啶衍生物用于其生产的方法，其作为药物的用途以及包含它们的药物组合物。
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5.发明公开PYRAZOLO[1,5-A]PYRIMIDIN-7-YL-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES 审中-公开并[1,5-a]嘧啶-7-基胺衍生物蛋白激酶依赖性疾病治疗
公开(公告)号：EP1708710A1
公开(公告)日：2006-10-11
申请号：EP05706961.9
申请日：2005-01-21
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BOLD, Guido , FLOERSHEIMER, Andreas , FURET, Pascal , IMBACH, Patricia , MASUYA, Keiichi , SCHOEPFER, Joseph , MARTINY-BARON, Georg
IPC分类号： A61K31/505
CPC分类号： C07D487/04 , A61K31/505
摘要： The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.
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6.发明公开DIARYL UREA DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES 审中-公开蛋白激酶依赖性疾病治疗的二芳基脲衍生物
公开(公告)号：EP1689376A2
公开(公告)日：2006-08-16
申请号：EP04798101.4
申请日：2004-11-26
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BOLD, Guido , CARAVATTI, Giorgio , FLOERSHEIMER, Andreas , GUAGNANO, Vito , IMBACH, Patricia , MASUYA, Keiichi , ROESEL, Johannes , VAUPEL, Andrea , GARCIA-ECHEVERRIA, Carlos
IPC分类号： A61K31/00
CPC分类号： C04B35/632 , C07D239/34 , C07D239/47 , C07D401/12 , C07D403/12
摘要： The invention relates to the use of diaryl urea derivatives for the manufacture of pharmaceutical compositions for the treatment of RET dependent disorders, especially RET dependent tumor diseases. The invention further relates to novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives and their use in the treatment of the animal or human body, especially in the treatment of a protein kinase dependent disease, to pharmaceutical compositions comprising such novel N-[4-pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives and to the use of such novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as tumour diseases.
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7.发明公开1H-IMIDAZOQUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS 有权1 H-IMIDAZOCHINOLINDERIVATE作为蛋白激酶抑制剂
公开(公告)号：EP1687305A1
公开(公告)日：2006-08-09
申请号：EP04798017.2
申请日：2004-11-19
申请人： Novartis AG , Novartis Pharma GmbH
发明人： CAPRARO, Hans-Georg , CARAVATTI, Giorgio , FURET, Pascal , GARCIA-ECHEVERRIA, Carlos , IMBACH, Patricia , STAUFFER, Frédéric
IPC分类号： C07D471/04 , A61K31/435 , A61P35/00 , C07D235/00 , C07D221/00
CPC分类号： C07D471/04
摘要： The invention relates to imidazoquinolines of formula (I) for use in the treatment of protein kinase dependent diseases; pharmaceutical preparations comprinsing an imidazoquinoline, especially for the treatment of a pretein kinase dependent disease; novel imidazoquinolines; and a process for the preparation of the novel imidazoquinilines.
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8.发明公开2,4-DI (PHENYLAMINO) PYRIMIDINES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开2,4-二（苯基氨基）嘧啶类所产生增殖性疾病的治疗是合适的
公开(公告)号：EP1663992A1
公开(公告)日：2006-06-07
申请号：EP04765358.9
申请日：2004-09-17
申请人： Novartis AG , Novartis Pharma GmbH
发明人： IMBACH, Patricia , ROESEL, Johannes
IPC分类号： C07D239/48 , C07D405/12 , C07D403/12 , C07D401/12 , C07D401/14 , A61K31/506 , A61K35/00
CPC分类号： C07D403/14 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , C04B35/632 , C07D239/48 , C07D401/12 , C07D403/12
摘要： There is provided a method of preventing or treating proliferative disorders such as a tumor disease, by inhibiting ALK activity with compounds of formula (I) wherein X, R1, R2 , R3 , R4 , R5, R6, R7,R8 and R9 are as indicated in claim 1.
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9.发明授权2-AMINO-3-HYDROXY-4-TERT-LEUCYL-AMINO-5-PHENYL-PENTANOIC ACID AMIDE DERIVATIVES 有权的2-氨基-3-羟基-4-叔 - 亮氨酰 - 氨基-5-苯基 - 戊酸酰胺衍生物
公开(公告)号：EP1290012B1
公开(公告)日：2006-05-10
申请号：EP01943442.2
申请日：2001-05-23
申请人： Novartis AG , Novartis Pharma GmbH
CPC分类号： C07K5/0215 , A61K38/00
摘要： The invention relates to compounds of formula (I), wherein the substituents and symbols are defined as indicated in the description, to processes for the preparation thereof, to medicaments comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.
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10.发明公开2-AMINO-3-HYDROXY-4-TERT-LEUCYL-AMINO-5-PHENYL-PENTANOIC ACID AMIDE DERIVATIVES 有权氨基酸2-氨基-3-羟基-4-叔丁基 - 氨基-5-苯基 - 戊烷
公开(公告)号：EP1290012A2
公开(公告)日：2003-03-12
申请号：EP01943442.2
申请日：2001-05-23
申请人： Novartis AG , Novartis Pharma GmbH
CPC分类号： C07K5/0215 , A61K38/00
摘要： The invention relates to compounds of formula (I), wherein the substituents and symbols are defined as indicated in the description, to processes for the preparation thereof, to medicaments comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.
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