-
公开(公告)号：EP2250185A1
公开(公告)日：2010-11-17
申请号：EP08869088.8
申请日：2008-12-23
Applicant: Virochem Pharma Inc.
Inventor： MOINET, CHRISTOPHE , HALAB, Liliane , TURCOTTE, Nathalie , BUBENIK, Monica , COURCHESNE, Marc , POISSON, Carl , PEREIRA, Oswy, Z. , NGUYEN-BA, Paul , LIU, Bingcan , CHAURET, Nathalie , CADILHAC, Caroline , CHAN CHUN KONG, Laval
IPC: C07J63/00 , A61K31/575 , A61K31/58 , A61K45/00 , A61P31/12 , A61P31/18 , C07J41/00 , C07J43/00 , C07J53/00
CPC classification number: A61K45/06 , A61K31/575 , A61K31/58 , A61K38/05 , A61K38/55 , A61K2300/00
Abstract: The invention relates to 21-keto triterpene compounds of formula (I): wherein R
1 , X, and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.Abstract translation: 本发明涉及式（I）的21-酮三萜化合物：其中R 1，X和Y如本文所定义，及其药学上可接受的盐和溶剂化物。 这些化合物表现出显着的抗HIV活性。 因此，本发明还涉及预防或治疗HIV感染的方法，其通过将治疗有效量的式（I）化合物或其药学上可接受的盐或溶剂化物给予需要这种治疗的受试者。
-
公开(公告)号：EP2240504A1
公开(公告)日：2010-10-20
申请号：EP08867782.8
申请日：2008-12-23
Applicant: Virochem Pharma Inc.
Inventor： MOINET, Christophe , CHAN CHUN KONG, LAVAL , COURCHESNE, Marc , HALAB, LILIANE , CHAURET, Nathalie
IPC: C07J63/00 , A61K31/575 , A61K31/58 , A61K45/00 , A61P31/12 , A61P31/18 , C07J41/00 , C07J43/00 , C07J53/00
CPC classification number: A61K31/575 , A61K31/58 , A61K45/06 , A61K2300/00
Abstract: The invention relates to 21 -keto triterpene compounds of formula (I): wherein R1, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.
