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1.发明公开公开(公告)号：EP2275398A4
公开(公告)日：2012-05-30
申请号：EP09733969
申请日：2009-01-20
Applicant: ZHEJIANG JIUZHOU PHARM CO LTD
Inventor： ZHOU QILIN , LI SHEN , ZHU SHOUFEI , ZHANG CANMING , WANG LIXIN
IPC: C07C51/347 , B01J31/18 , B01J31/22 , B01J31/24 , C07B53/00 , C07C51/36 , C07C57/04 , C07C201/12 , C07D263/12 , C07D307/54 , C07F9/653 , C07F15/00 , C07F17/02
CPC classification number: C07F9/653 , B01J31/189 , B01J31/2295 , B01J2231/645 , B01J2531/827 , C07B53/00 , C07B2200/07 , C07C51/36 , C07D263/12 , C07D307/54 , C07F15/0033 , C07F17/02 , C07C57/30 , C07C59/64
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2.发明公开
公开(公告)号：EP3225614A4
公开(公告)日：2018-08-01
申请号：EP15862425
申请日：2015-08-08
Applicant: ZHEJIANG JIUZHOU PHARM CO LTD
Inventor： ZHOU QILIN , XIE JIANHUA , YANG XIAOHUI , WANG LIXIN
IPC: C07C67/48 , B01J31/24 , C07C29/149 , C07C31/20 , C07C33/26 , C07C69/675 , C07C69/708 , C07C69/732 , C07D309/30
CPC classification number: C07C69/675 , B01J31/181 , B01J31/189 , B01J31/24 , B01J31/249 , B01J2231/646 , B01J2531/827 , C07B53/00 , C07B57/00 , C07B2200/07 , C07C29/149 , C07C31/20 , C07C33/26 , C07C67/48 , C07C69/708 , C07C69/732 , C07D211/02 , C07D211/12 , C07D305/06 , C07D309/06 , C07D309/30 , C07D473/06
Abstract: The present invention relates to kinetic resolution of racemic ´ -hydroxyl ester via asymmetric catalytic hydrogenation and an application thereof. In the presence of chiral spiro pyridyl phosphine ligand Iridium catalyst and base, racemic ´-hydroxyl esters were subjected to asymmetric catalytic hydrogenation to obtain extent optical purity chiral ´-hydroxyl esters and corresponding 1,5-diols. The method is a new, efficient, highly selective, economical, desirably operable and environmentally friendly method suitable for industrial production. An optically active chiral ´ -hydroxyl ester and 1,5-diols can be obtained at very high enantioselectivity and yield with relatively low usage of catalyst. The chiral ´ -hydroxyl ester and 1,5-diols obtained by using the method can be used as a critical raw material for asymmetric synthesis of chiral drugs (R)-lisofylline and natural drugs (+)-civet, (-)-indolizidine 167B and (-)-coniine.
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3.发明公开SPIROBENZYLAMINE-PHOSPHINE, PREPARATION METHOD THEREFOR AND USE THEREOF 审中-公开SPIROBENZYLAMIN膦，用于生产及其用途
公开(公告)号：EP2752419A4
公开(公告)日：2015-04-29
申请号：EP12828043
申请日：2012-07-27
Applicant: ZHEJIANG JIUZHOU PHARM CO LTD
Inventor： ZHOU QILIN , ZHU SHOUFEI , YU YANBO , LI KUN , WANG LIXIN
IPC: C07F9/50 , B01J31/24 , C07B35/02 , C07C51/36 , C07C53/128 , C07C57/30 , C07C57/58 , C07C59/125 , C07C59/13 , C07C59/64 , C07C67/303 , C07C69/42 , C07F19/00
CPC classification number: C07F15/004 , B01J31/189 , B01J2231/645 , B01J2531/827 , C07B35/02 , C07B53/00 , C07B2200/07 , C07C51/36 , C07F9/5022 , C07F9/505 , C07F15/0033 , C07C53/128 , C07C57/30 , C07C57/58 , C07C59/125 , C07C59/13 , C07C59/64
Abstract: The present invention relates to a spirobenzylamine-phosphine, preparation method therefor and use thereof. The compound has a structure represented by formula (I), wherein n=0 to 3; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 having a value as defined in claim 1. Starting from the substituted 7-trifluoromesyloxy-7'-diarylphosphino-1, 1'-spiro-dihydroindene, the compound is synthesized in a two-step or three-step reactions. The new spirobenzylamine-phosphine is complexed with an iridium precursor and is subjected to ion exchange, to give an Iridium/spirobenzylamine-phosphine complex comprising various anions. The spiro benzyl amine-phosphine/Iridium complex according to the present invention may be used for catalyzing asymmetry hydrogenation of a variety of alpha-substituted acrylic acids, has high activity and enantio-selectivity, and has a good prospect of industrialization.
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公开(公告)号：EP2272853A4
公开(公告)日：2011-05-18
申请号：EP09734964
申请日：2009-01-20
Applicant: ZHEJIANG JIUZHOU PHARM CO LTD
Inventor： ZHOU QILIN , ZHU SHOUFEI , LI SHEN , WANG LIXIN , SONG SONG
CPC classification number: C07F9/653 , B01J31/189 , B01J2231/645 , B01J2531/827 , C07B2200/07 , C07C51/36 , C07F15/0033 , C07F15/0046 , C07C59/68 , C07C57/30
