公开(公告)号：EP4357358A1

公开(公告)日：2024-04-24

申请号：EP22824309.3

申请日：2022-06-17

申请人： Beijing Tuo Jie Biopharmaceutical Co. Ltd.

发明人： LIU, Weibing ,  HUANG, Xuchao ,  ZHANG, Xiaoqian ,  WU, Fangzhou ,  WANG, Lei ,  QU, Liang

IPC分类号： C07K14/605 ,  A61K38/26 ,  A61P3/10

CPC分类号： C07K14/605 ,  A61P3/10 ,  A61K38/26

摘要： A glucagon analog and the medical use thereof. Specifically, the glucagon analog has a significantly improved in vitro activity, excellent physical/chemical stability, and high solubility, and can be used to treat metabolic diseases such as hypoglycemia, obesity, and diabetes.

公开(公告)号：EP4353248A1

公开(公告)日：2024-04-17

申请号：EP22819555.8

申请日：2022-06-08

申请人： Beijing Tuo Jie Biopharmaceutical Co. Ltd.

发明人： TONG, Xinyong ,  ZOU, Aifeng ,  WANG, Haifeng ,  YANG, Tingting ,  YANG, Yi ,  ZHOU, Yin

IPC分类号： A61K38/08 ,  A61P3/14 ,  A61P5/20

CPC分类号： A61P5/20 ,  A61K38/08 ,  A61P3/14

摘要： Provided are a calcium-sensing receptor (CaSR) agonist composition and an application thereof. Specifically, provided is a pharmaceutical composition of a polypeptide CaSR agonist, the composition comprising an active ingredient, a buffer and an osmotic pressure regulator. The present composition has high stability, may be stored for a long time, may effectively reduce the plasma parathyroid hormone, and has a low level of histamine release.