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公开(公告)号：EP0999824A1
公开(公告)日：2000-05-17
申请号：EP98925803.3
申请日：1998-06-01
CPC分类号： A61K9/0068 , C22C23/02
摘要： An alloy for use in the manufacture of boli for adminstration to ruminant animals, the alloy including a major proportion of magnesium, aluminium in an amount of less than 8 % by weight and copper to enhance the rate of the galvanic corrosion of the alloy, the copper being present in an amount of more than 0.5 % by weight. Example boli include a bolus comprising a tubular sheath made from the alloy which surrounds a core component, the sheath and core being galvanically coupled. Boli including the alloy of the present invention provide relatively high magnesium release rates as well as providing an overall higher proportion of available magnesium for assimilation by the animal.
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公开(公告)号：EP0240109B1
公开(公告)日：1990-12-12
申请号：EP87300938.5
申请日：1987-02-03
CPC分类号： A61K9/0068 , A61M31/002 , C22C23/04
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3.发明公开CONTROLLED RELEASE DEVICES AND STRUCTURAL ELEMENTS FOR USE IN THEIR MANUFACTURE 有权设备技术控制的供给和结构元素FOR USE生产
公开(公告)号：EP1868566A2
公开(公告)日：2007-12-26
申请号：EP06726727.8
申请日：2006-04-10
CPC分类号： A61K9/0068
摘要： A structural element (2), suitable for use in the manufacture of a release device for intraruminal administration of an active agent to a ruminant animal, is of a compacted material, which material comprises a mixture of powdered iron, graphite and optionally copper, the graphite being present in the mixture in an amount of from 2 to 7wt%, the copper in an amount of from 0 to 5wt% and the iron in an amount of from 88 to 98wt%, by weight of the total weight of iron, copper and graphite. A plurality of structural elements (2) may be assembled to provide a structural unit (4) of a release device.
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公开(公告)号：EP0482947B1
公开(公告)日：1996-03-06
申请号：EP91309890.1
申请日：1991-10-25
CPC分类号： A61K9/0092 , A61K9/0068 , C22C23/00
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公开(公告)号：EP0240109A1
公开(公告)日：1987-10-07
申请号：EP87300938.5
申请日：1987-02-03
CPC分类号： A61K9/0068 , A61M31/002 , C22C23/04
摘要： A pellet or bolus for administration to a ruminant by deposition in its rumeno-reticular sac where it is eroded away by rumen juices and releases active agent(s) and/or components, either continuously or in pulsed doses, comprises or incorporates a magnesium-based alloy which comprised at least 40% of magnesium, at least 30% zinc and up to 20% aluminium and, optionally, copper up to 5%, and trace elements, selected from cobalt, manganese, nickel and selenium up to 1 %, the percentages being by weight. A paste can be made by heating the alloy to between its solidus and liquidus points, when it can be admixed with lead shot for weighting the bolus.
In the illustrated case, the bolus comprises tubular sheath (14) which contains alloyliron shot filling (16). However, the alloy can be used for any appropriate component of the bolus.摘要翻译： 用于通过沉积在其瘤胃网状囊中向反刍动物施用的颗粒或丸剂，其中其被胃液侵蚀并且连续地或以脉冲剂量释放活性剂和/或组分，包含或掺入镁 - 其包含至少40％的镁，至少30％的锌和至多20％的铝，以及任选的至多5％的铜以及选自钴，锰，镍和硒至多1％的微量元素， 百分比以重量计。 可以通过将合金加热到其固相和液相点之间，当它可以与用于称重推注的铅射流混合时制成糊状物。 在所示的情况下，推注物包括管状护套（14），其包含合金/铁注射填充物（16）。 然而，该合金可用于推注的任何合适的组分。
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6.发明公开Zinc based alloy bolus for veterinary use 审中-公开Bolus aus einer Zinklegierung bestimmtfürtierärzlicheVerwendung
公开(公告)号：EP1225238A1
公开(公告)日：2002-07-24
申请号：EP01310881.6
申请日：2001-12-24
摘要： A metal alloy comprising, by weight of the total weight of the alloy:
(a) at least 50wt% of zinc;
(b) from 30 to 49wt% of magnesium; and
(c) up to 6wt% of copper,
and a bolus comprising such an alloy, as well as the use of this alloy in the preparation of a medicament for the treatment or prevention of facial eczema, foot rot or hypomagnesaemia in an animal.摘要翻译： 一种金属合金，其以合金的总重量的重量计含有：（a）至少50wt％的锌; （b）30〜49重量％的镁; 和（c）至多6重量％的铜，以及包含这种合金的推注剂，以及该合金在制备用于治疗或预防动物中的面部湿疹，脚腐烂或低镁血症的药物中的用途。
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公开(公告)号：EP0243111A3
公开(公告)日：1989-06-07
申请号：EP87303394.8
申请日：1987-04-16
CPC分类号： A61K9/0068 , A23K40/20 , A23K40/35 , A61J3/06 , A61M31/002
摘要： A pellet for administration to ruminants to supply magnesium and other biologically active material, for example, anthelmintics or antibiotics comrpises a tube of magnesium alloy (1) enclosing a core or filling (3). The core (3) typically comprises mainly iron shot as weighting material, a biologically active material if desired and an electrically conductive material such as carbon or graphite. The graphite ensures that the core (3) as a whole is conductive and provides a cathode electrically coupled with the magnesium alloy tube (1) to form a galvanic cell. Liquor in the rumen serves as an electrolyte to cause galvanic corrosion of the magnesium tube (1) to release the active material contained in the core (3). A protective coating (5) of resin is provided on the tube's exterior surface except on at least one end (4) so that the corrosion is limited to the exposed surfaces only. An alternative embodiment (Fig. 4) comprises a control magnesium alloy rod or shaft (11) around which a cylinder (13) of the electrically conductive component is pressed. The cylinder contain iron shot and graphite in similar proportions to the core (3) in the first embodiment and is also provided with a protective resin coating (12) to restrict corrosion to one or both ends of the rod (11).
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公开(公告)号：EP0140632B1
公开(公告)日：1989-02-01
申请号：EP84307033.5
申请日：1984-10-15
CPC分类号： A61K9/0068 , A61J3/06 , A61M31/002
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公开(公告)号：EP0140632A2
公开(公告)日：1985-05-08
申请号：EP84307033.5
申请日：1984-10-15
CPC分类号： A61K9/0068 , A61J3/06 , A61M31/002
摘要： A pellet for administration into and reside in the rumeno-reticular sac of a ruminant and to release successive doses of an active agent, such as an anthelmentic, comprises an assembly (10) of discs (12) each having a peripheral skirt (14) on one side and an inwardly-spaced skirt (16) on the other so that such discs can interfit by said skirts (14, 16) and define therebetween cavities (18) each containing a respective active agent dose (24). A weighting slug (20) is provided at one end of the assembly (10) which is enclosed except at one end by a surrounding plastics sheath (26) so that rumen juices may attack and erode the successive discs (12) to release the successive doses (24). The discs (12) are of a magnesium-based alloy and the slug (20) is of a Zinc-based alloy.
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公开(公告)号：EP0999824B1
公开(公告)日：2003-03-12
申请号：EP98925803.3
申请日：1998-06-01
CPC分类号： A61K9/0068 , C22C23/02
摘要： An alloy for use in the manufacture of boli for adminstration to ruminant animals, the alloy including a major proportion of magnesium, aluminium in an amount of less than 8 % by weight and copper to enhance the rate of the galvanic corrosion of the alloy, the copper being present in an amount of more than 0.5 % by weight. Example boli include a bolus comprising a tubular sheath made from the alloy which surrounds a core component, the sheath and core being galvanically coupled. Boli including the alloy of the present invention provide relatively high magnesium release rates as well as providing an overall higher proportion of available magnesium for assimilation by the animal.
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