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公开(公告)号：EP3687577A1
公开(公告)日：2020-08-05
申请号：EP18792671.2
申请日：2018-09-28
IPC分类号： A61K45/06 , A61K31/166 , A61K31/7125 , A61P21/00
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公开(公告)号：EP3068224A1
公开(公告)日：2016-09-21
申请号：EP14861495.1
申请日：2014-11-14
发明人： JIROUSEK, Michael R. , MILNE, Jill C. , VU, Chi B.
IPC分类号： A01N43/40
CPC分类号： A61K47/481 , A61K31/4406 , A61K31/4439 , A61K31/455 , A61K45/06 , A61K47/55 , C07D213/82 , C07D401/12 , A61K2300/00
摘要： The invention provides fatty acid niacin conjugates; pharmaceutical compositions comprising an effective amount of the fatty acid niacin conjugate; and methods for treating or preventing a metabolic disease comprising the administration of an effective amount of the fatty acid niacin conjugate.
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3.发明公开USE OF INTRACELLULAR ENZYMES FOR THE RELEASE OF COVALENTLY LINKED BIOACTIVES 审中-公开使用RELEASE共价键结合生物制剂细胞内酶
公开(公告)号：EP2949344A3
公开(公告)日：2016-01-13
申请号：EP15173103.1
申请日：2012-03-16
IPC分类号： A61K47/48
CPC分类号： A61K47/48338 , A61K31/194 , A61K31/198 , A61K31/202 , A61K31/455 , A61K31/60 , A61K31/618 , A61K45/06 , A61K47/542 , A61K47/55 , A61K47/65 , Y02A50/422 , A61K2300/00
摘要： The present invention relates to targeting an intracellular enzyme for release of covalently linked bioactives which results in a synergistic effect between the bioactives. The present invention relates to the use of bioactives that are directly connected covalently or through a covalent molecular linker which have increased therapeutic activity when released as the free bioactives by intracellular enzymes as compared to when the bioactives are administered individually (i.e. not covalendy linked). Further, methods are described of administering to patients in need thereof, bioactives as linked bioactives having increased therapeutic activity. Accordingly, this invention also relates to methods of treating patients for certain diseases.
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公开(公告)号：EP2813486B1
公开(公告)日：2017-10-25
申请号：EP14176625.3
申请日：2009-07-08
IPC分类号： C07C233/18 , C07C233/49 , C07C233/55 , C07C235/60 , C07C237/22 , C07C271/28 , C07C275/42 , C07D295/192 , C07C69/90 , C07C69/94 , C07C69/587 , A61K31/165 , A61K31/17 , A61K31/232 , A61K31/235 , A61P29/00
CPC分类号： A61K31/609 , A61K31/60 , C07C69/86 , C07C69/94 , C07C233/18 , C07C233/49 , C07C233/55 , C07C235/52 , C07C235/60 , C07C237/22 , C07C271/28 , C07C275/42 , C07D295/182 , C07D295/192
摘要： The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.
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公开(公告)号：EP2473045B1
公开(公告)日：2016-08-17
申请号：EP10814349.6
申请日：2010-08-31
IPC分类号： C07D213/82 , A01N43/40 , A61K31/44
CPC分类号： A61K47/542 , A61K31/202 , A61K31/44 , A61K31/4406 , A61K31/455 , A61K41/0038 , A61K47/55 , C07D213/80 , C07D213/82
摘要： The invention relates to fatty acid niacin conjugates; compositions comprising an effective amount of a fatty acid niacin conjugate; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a fatty acid niacin conjugate.
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公开(公告)号：EP2813486A1
公开(公告)日：2014-12-17
申请号：EP14176625.3
申请日：2009-07-08
IPC分类号： C07C233/18 , C07C233/49 , C07C233/55 , C07C235/60 , C07C237/22 , C07C271/28 , C07C275/42 , C07D295/192 , C07C69/90 , C07C69/94 , C07C69/587 , A61K31/165 , A61K31/17 , A61K31/232 , A61K31/235 , A61P29/00
CPC分类号： A61K31/609 , A61K31/60 , C07C69/86 , C07C69/94 , C07C233/18 , C07C233/49 , C07C233/55 , C07C235/52 , C07C235/60 , C07C237/22 , C07C271/28 , C07C275/42 , C07D295/182 , C07D295/192
摘要： The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.
摘要翻译： 本发明涉及脂肪酸乙酰化水杨酸衍生物; 包含有效量的脂肪酸乙酰化水杨酸衍生物的组合物; 以及治疗或预防炎性病症的方法，包括施用有效量的脂肪酸乙酰化水杨酸衍生物。
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公开(公告)号：EP2521447A1
公开(公告)日：2012-11-14
申请号：EP11732212.3
申请日：2011-01-07
CPC分类号： C07C235/76 , A61K31/195 , A61K31/197 , A61K31/221 , A61K31/225 , A61K31/385 , A61K31/4015 , A61K31/495 , A61K47/55 , C07C233/20 , C07C233/38 , C07C233/49 , C07C323/41 , C07D207/14 , C07D207/40 , C07D207/416 , C07D241/04 , C07D295/18 , C07D339/04
摘要： The invention relates to Fatty Acid Fumarate Derivatives; compositions comprising an effective amount of a Fatty Acid Fumarate Derivative; and methods for treating or preventing cancer, a metabolic disorder or neurodegenerative disorder comprising the administration of an effective amount of a Fatty Acid Fumarate Derivative.
摘要翻译： 本发明涉及富马酸脂肪酸衍生物; 包含有效量的富马酸脂肪酸衍生物的组合物; 以及用于治疗或预防癌症，代谢紊乱或神经变性疾病的方法，包括施用有效量的富马酸脂肪酸衍生物。
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公开(公告)号：EP3687547A1
公开(公告)日：2020-08-05
申请号：EP18792669.6
申请日：2018-09-28
IPC分类号： A61K31/7125 , A61K31/166 , A61P21/00 , A61K45/06
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公开(公告)号：EP3687519A1
公开(公告)日：2020-08-05
申请号：EP18792670.4
申请日：2018-09-28
IPC分类号： A61K31/166 , A61K31/7125 , A61K45/06 , A61P21/00
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公开(公告)号：EP2315740B1
公开(公告)日：2017-10-25
申请号：EP09790168.0
申请日：2009-07-08
IPC分类号： C07C233/18 , C07C233/49 , C07C233/55 , C07C235/60 , C07C237/22 , C07C271/28 , C07C275/42 , C07D295/192 , C07C69/90 , C07C69/94 , C07C69/587 , A61K31/165 , A61K31/17 , A61K31/232 , A61K31/235
CPC分类号： A61K31/609 , A61K31/60 , C07C69/86 , C07C69/94 , C07C233/18 , C07C233/49 , C07C233/55 , C07C235/52 , C07C235/60 , C07C237/22 , C07C271/28 , C07C275/42 , C07D295/182 , C07D295/192
摘要： The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.
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