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1.发明公开TARGETING SYSTEMS AND METHODS FOR FROZEN ALIQUOTTER FOR BIOLOGICAL SAMPLES 审中-公开瞄准系统和方法用于冷冻ALIQUOTIERUNGEN生物样品
公开(公告)号：EP2992311A1
公开(公告)日：2016-03-09
申请号：EP14734283.6
申请日：2014-05-05
发明人： BASQUE, Todd , CHIN, Larry , LOONEY, Timothy , WEBER, Eric
摘要： A system for taking frozen sample cores from frozen biological samples includes a coring bit mount adapted to hold a coring bit and a carriage supporting the coring bit mount. A drive system is adapted to produce relative movement between the carriage and the frozen biological samples for moving the coring bit along a path into the frozen biological samples. A cutting action motor is supported by the carriage and adapted to drive a cutting motion of the coring bit as the drive system drives the coring bit into the frozen biological samples. A targeting system is adapted to direct electromagnetic radiation onto one of the frozen biological samples when the sample is positioned in the path of the coring bit. The electromagnetic radiation is adapted to produce a display on the frozen biological sample indicating where the path of the coring bit intersects the frozen biological sample.
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2.发明公开ROBOTIC END EFFECTOR FOR FROZEN ALIQUOTTER AND METHODS OF TAKING A FROZEN ALIQUOT FROM BIOLOGICAL SAMPLES 审中-公开机器人末端执行器冷冻等分和方法收集冷冻等分从生物样品
公开(公告)号：EP2807465A1
公开(公告)日：2014-12-03
申请号：EP13740576.7
申请日：2013-01-28
CPC分类号： G01N1/08 , B25J15/0019 , G01F17/00 , G01N1/42 , G01N35/0099 , G01N35/10 , G01N2035/1025 , Y10S901/41
摘要： A robotic end effector for collecting frozen aliquots from an array of frozen samples in a plurality of containers has a coring bit for taking frozen sample cores from the frozen samples and a frozen sample core extraction system adapted to extract frozen sample cores from the frozen samples. A fill level detection system is adapted to detect the positions of the surfaces of the frozen samples. A processor is adapted to receive signals from the fill level detection system and use the signals and information concerning operation of the frozen sample core extraction system to determine at least one of the following: (a) the amount of material contained in a frozen sample core obtained by the coring bit; and (b) the number of frozen sample cores needed from a particular frozen sample to obtain a predetermined amount of material from that frozen sample.
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3.发明公开APPARATUS AND METHODS FOR ALIQUOTTING FROZEN SAMPLES 审中-公开VORRICHTUNG UND VERFAHREN ZUR ALIQUOTIERUNG GEFRORENER PROBEN
公开(公告)号：EP2877827A2
公开(公告)日：2015-06-03
申请号：EP13747554.7
申请日：2013-07-24
摘要： A single-use coring probe for collecting a frozen aliquot from a frozen biological sample includes a hollow coring bit and an ejector adapted. The ejector is operable to eject a frozen sample core from the bit as it moves from a retracted position to an extended position. Use of the ejector converts the probe to a disabled configuration to discourage reuse of the coring probe to obtain another sample. The probe may include a locking mechanism adapted to prevent re-use of the single-use coring probe by locking the ejector in the extended position. A hand-held coring device can be used to take frozen sample cores from frozen samples. A tissue container is suitable for holding a frozen tissue sample in frozen storage and also for holding the sample while the sample is sectioned and/or a full-depth frozen sample core is extracted from the frozen tissue.
摘要翻译： 用于从冷冻的生物样品中收集冷冻等分试样的一次性取芯探针包括中空取芯钻头和适配的喷射器。 喷射器可操作以在冷冻样品芯从缩回位置移动到延伸位置时将其从所述钻头中排出。 使用喷射器将探头转换为禁用的配置，以阻止取芯探针重新使用以获得另一个样品。 探针可以包括锁定机构，其适于通过将喷射器锁定在伸出位置来防止再次使用单次使用的取芯探针。 手提取芯装置可用于从冷冻样品中取出冷冻的样品芯。 组织容器适合于将冷冻的组织样品保存在冷冻储存器中，并且还用于在样品切片时保持样品，和/或从冷冻组织中提取全深度冷冻样品芯。
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4.发明公开
公开(公告)号：EP2845013A2
公开(公告)日：2015-03-11
申请号：EP13724056.0
申请日：2013-04-30
发明人： RAMEZANIFARD, Mohammadreza , SOKHANVAR, Saeed , BASQUE, Todd , FULLER, Peter L. , SWEETLAND, Matthew
CPC分类号： G01N1/286 , G01N35/00732 , G01N35/0099 , G01N2035/0091
摘要： A machine vision system for use with a system that takes frozen sample cores from samples that are in containers includes a camera. A processor is configured to receive image data from the camera and to determine locations where frozen sample cores have already been taken. A method of determining one or more locations where a frozen sample core have already been taken from frozen samples includes operating a robotic system to position one of the containers on a platform at a station for receiving the container while a frozen sample core is extracted from the frozen sample contained in the container. The camera is used to capture an image of the frozen sample. Contrast in the captured image is evaluated to identify one or more bore candidates. The processor uses the image to determine whether or not the bore candidates are real bores or artifacts.
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