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公开(公告)号：EP4406596A2
公开(公告)日：2024-07-31
申请号：EP24181562.0
申请日：2019-06-14
Applicant: Probiotech USA LLC
IPC: A61P15/02
CPC classification number: A61K36/82 , A61K35/745 , A61K35/747 , A61K2035/11520130101 , A61K9/0034 , A61K9/025 , A61K9/4808 , A61K9/0031 , A61K2035/12620130101 , A61P1/00 , A61P15/02 , A61K9/4816
Abstract: A method for treating the gastro-intestinal or a urogenital system of a subject with prebiotic nutrients and probiotic bacteria is provided. Multi-chamber products are described which include at least two chambers wherein probiotic bacteria or human microbiome transplants are contained in one or more inner chambers and wherein prebiotic nutrients are contained in an outer chamber, the outer chamber completely enclosing the inner chamber(s). One or both chambers may contain a pharmaceutically acceptable material that is solid outside the human body when in a dry environment, but that melts at internal body temperature. The products may be administered by oral, rectal, vaginal, or urethral routes.
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公开(公告)号：EP1474106A1
公开(公告)日：2004-11-10
申请号：EP03715922.5
申请日：2003-01-07
Applicant: KIMBERLY-CLARK WORLDWIDE, INC.
Inventor： GEHLING, Steven, Craig
CPC classification number: A61M31/00 , A61F13/202 , A61F13/2051 , A61F13/2074 , A61F13/28 , A61F13/8405 , A61F2013/8414 , A61F2013/8417 , A61K9/0036 , A61K9/025 , A61M2210/1475 , Y10S514/966 , Y10S514/967
Abstract: A tampon adapted to deliver a therapeutic agent, the tampon including a tampon body that is manufactured at a first manufacturing facility; and a dosage form coupled to the body, wherein the dosage form includes a formulation including a therapeutic agent, and wherein the dosage form is manufactured at a second manufacturing facility. Also, a method for producing a medicated tampon including manufacturing a tampon body at a first manufacturing facility; manufacturing a dosage form at a second manufacturing facility, wherein the dosage form includes a formulation including a therapeutic agent; and coupling the dosage form to the tampon body.
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公开(公告)号：EP0486117B1
公开(公告)日：1996-02-07
申请号：EP91203148.1
申请日：1991-06-26
Inventor： Embil, Koral , Morton, Oswald
CPC classification number: A61K9/1635 , A61K9/0031 , A61K9/025 , Y10S424/15 , Y10S514/966
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公开(公告)号：EP0476205A1
公开(公告)日：1992-03-25
申请号：EP90313718.0
申请日：1990-12-14
Applicant: TORII & CO., LTD.
Inventor： Uekama, Kaneto
CPC classification number: A61K9/02 , A61K9/025 , A61K31/485 , A61K47/6951 , B82Y5/00
Abstract: A sustained release hollow type suppository for rectal administration comprising a mixture of morphine, a-cyclodextrin and a thickener.
Abstract translation: 缓释中空型栓剂用于直肠给药，包括吗啡，α-环糊精和增稠剂的混合物。
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公开(公告)号：EP0451182A1
公开(公告)日：1991-10-16
申请号：EP90900941.0
申请日：1989-12-29
Inventor： MORTON, Oswald , EMBIL, Koral
CPC classification number: A61K9/025 , A61K9/0031 , Y10S514/882 , Y10S514/966
Abstract: L'invention concerne une composition pharmaceutique à phases multiples permettant de lutter contre une maladie ano-rectale, qui comprend au moins une phase, se composant d'un ou de plusieurs médicaments de lutte contre ladite maladie, et au moins une phase à action retardée libérant une huile de silicone. Ladite composition applique sur la région touchée par ladite maladie un ou plusieurs médicaments et ensuite une couche d'huile de silicone, empêchant ainsi que les médicaments ne soient emportés par un flux aqueux.
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6.发明公开Morphine hydrochloride preparation for rectal administration 失效吗啡氯化物 - Zubereitung zur rektalen Verabreichung。
公开(公告)号：EP0430414A1
公开(公告)日：1991-06-05
申请号：EP90311213.4
申请日：1990-10-12
Applicant: TORII & CO., LTD.
Inventor： Uekama,Kaneto , Tanaka,Joji,
IPC: A61K31/485 , A61K47/48 , A61K9/02
CPC classification number: B82Y5/00 , A61K9/025 , A61K31/485 , A61K47/40 , A61K47/6951
Abstract: A hollow type suppository for rectal administration comprising a mixture of morphine hydrochloride with α-cyclodextrin, hydroxypropyl-α-cyclodextrin, dimethyl-β-cyclodextrin or hydroxypropyl-β-cyclodextrin.
Abstract translation: 用于直肠给药的中空型栓剂，其包含盐酸吗啡与α-环糊精，羟丙基-α-环糊精，二甲基-β-环糊精或羟丙基-β-环糊精的混合物。
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公开(公告)号：EP0137364A2
公开(公告)日：1985-04-17
申请号：EP84111104.0
申请日：1984-09-18
Applicant: Merck & Co., Inc.
Inventor： Allegretti, John E.
IPC: A61K9/02
CPC classification number: A61K9/0004 , A61K9/025
Abstract: A suppository of usual size, shape and materials of construction is disclosed which is well suited for its intended purpose, incorporating therein an art-recognized osmotic therapeutic system for delivery of a therapeutic agent, such as indomethacin, via the anal canal.
Abstract translation: 公开了通常尺寸，形状和结构材料的栓剂，其非常适合其预期目的，其中结合有本领域公认的用于通过肛管递送治疗剂（例如吲哚美辛）的渗透性治疗药物。
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8.发明公开
公开(公告)号：EP3267976A1
公开(公告)日：2018-01-17
申请号：EP16713673.8
申请日：2016-03-10
Applicant: CRISTCOT LLC
Inventor： DAVAGIAN, Jennifer J. , DEVARAJAN, Raj
IPC: A61K9/02 , A61K47/02 , A61K31/573
CPC classification number: A61K9/025 , A61K9/0031 , A61K9/02 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/007 , A61M2210/1064 , A61M2210/1067
Abstract: The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
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公开(公告)号：EP2753305A1
公开(公告)日：2014-07-16
申请号：EP12766721.0
申请日：2012-09-06
Applicant: Lipid Pharmaceuticals Ehf.
Inventor： LOFTSSON, Thorsteinn
CPC classification number: A61K31/167 , A61K9/0031 , A61K9/02 , A61K9/025 , A61K31/20 , A61K31/201 , A61K31/202 , A61K31/573 , A61K35/60 , A61K47/14 , A61K47/44
Abstract: The invention relates to coating of suppositories containing free unsaturated fatty acid, fatty acid ethyl ester and fatty acid monoglyceride that are susceptible to oxidative degradation. The coating retards oxidative degradation of unsaturated fatty acids and gives the suppository a non-oily and smooth surface. The coating will enhance the shelf-life of the suppository and allow their storage at room temperature for extended time period. The coating may or may not contain medicament such as local anesthetic or steroid. According to this invention chemically unstable fatty acids in coated suppositories can be used to stimulate the process of defecation or to treat disorders such as hemorrhoids, bacterial infections, viral infections and inflammations, as well as against fissura ani and pruritus ani. Furthermore, coating suppositories,that contain high concentrations of free fatty acids,can reduce acid induced rectal irritation.
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公开(公告)号：EP2512445A1
公开(公告)日：2012-10-24
申请号：EP10798005.4
申请日：2010-12-15
Applicant: Bene-Arnzeimittel GmbH
Inventor： METZ, Christian
IPC: A61K9/02 , A61K31/4439 , A61K9/48
CPC classification number: A61K9/025 , A61K9/4808 , A61K9/4858 , A61K9/5078 , A61K31/4439
Abstract: The present invention concerns the field of pharmaceutical technology and relates to a suppository for rectal administration comprising at least one pellet, in particular, a pellet comprising the proton pump inhibitor pantoprazole. In addition, the present invention concerns a process for preparing such a suppository.
