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1.发明公开公开(公告)号：EP0065286A3
公开(公告)日：1984-06-13
申请号：EP82104186
申请日：1982-05-12
Applicant: BOEHRINGER MANNHEIM GMBH
Inventor： VETTER, HELLMUTH, DR. , SCHEIBE, PETER, DR. , THUM, WALDEMAR , NAHER, GOTTHILF, DR.
IPC: A23J1/00 , A61K38/22 , A61K38/43 , A61K38/44 , A61K39/395 , C07K1/30 , C12N9/00 , C12N9/02 , C12N9/08 , C12N9/18 , C12N9/20 , C12P21/00 , C07G7/00
CPC classification number: C12Y110/03003 , A23J1/00 , C07K1/30 , C12N9/00 , C12N9/0063 , C12N9/0065 , C12N9/18 , C12N9/20 , Y10S435/814
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2.发明授权Verfahren zum Reinigen bzw. Anreichern von biologisch aktiven Proteinen und hierzu geeignetes Mittel 失效生物活性蛋白的纯化或浓缩过程及其适宜的方法
公开(公告)号：EP0065286B1
公开(公告)日：1986-10-08
申请号：EP82104186.0
申请日：1982-05-12
Applicant: BOEHRINGER MANNHEIM GMBH
Inventor： Vetter, Hellmuth, Dr. , Scheibe, Peter, Dr. , Thum, Waldemar , Näher, Gotthilf, Dr.
CPC classification number: C12Y110/03003 , A23J1/00 , C07K1/30 , C12N9/00 , C12N9/0063 , C12N9/0065 , C12N9/18 , C12N9/20 , Y10S435/814
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公开(公告)号：EP3180354A1
公开(公告)日：2017-06-21
申请号：EP15760323.4
申请日：2015-08-14
Applicant: Danisco US Inc.
Inventor： MADRID, Susan M.
CPC classification number: C12N15/52 , C07K14/37 , C12N9/0006 , C12N9/001 , C12N9/0022 , C12N9/0059 , C12N9/0061 , C12N9/0063 , C12N9/0069 , C12N9/0071 , C12N9/0089 , C12N9/242 , C12Y101/03005 , C12Y101/03009 , C12Y101/99018 , C12Y103/03005 , C12Y104/03002 , C12Y110/03001 , C12Y110/03002 , C12Y110/03003 , C12Y113/11024 , C12Y114/17001 , C12Y114/17003 , C12Y114/18001 , C12Y115/01001
Abstract: Aspects of the present disclosure are drawn to methods of improving the expression of secreted cuproenzymes from host cells by manipulating the expression level of one or more proteins involved in copper transport in the host cell, e.g., membrane-bound copper transporting ATPases and soluble copper transporters. The present disclosure also provides compositions containing such improved host cells as well as products derived from the improved host cells that contain one or more cuproenzymes of interest.
Abstract translation: 本公开的方面涉及通过操纵参与宿主细胞中的铜转运的一种或多种蛋白质的表达水平，例如膜结合的铜转运ATP酶和可溶性铜转运蛋白来改善来自宿主细胞的分泌型铜氧酶的表达的方法 。 本公开还提供了含有这种改进的宿主细胞的组合物以及衍生自含有一种或多种目的铜胺酶的改良宿主细胞的产物。
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公开(公告)号：EP2857503A4
公开(公告)日：2016-01-13
申请号：EP13794306
申请日：2013-05-23
Applicant: KYOWA MEDEX CO LTD
Inventor： KINJO KENTA , ARATAKE TOMOKO
CPC classification number: C12N9/96 , C12N9/0063 , C12Q1/26 , C12Y110/03003 , G01N2333/90235
Abstract: Provided are: a method for stabilizing an ascorbic acid oxidase; a method for preserving an ascorbic acid oxidase; and a stabilized composition of an ascorbic acid oxidase. A method for stabilizing an ascorbic acid oxidase and a method for preserving an ascorbic acid oxidase, each of the methods comprising allowing an ascorbic acid oxidase to coexist with nitrous acid or a salt thereof, or a nitrous acid ester in an aqueous medium; and a stabilized composition of an ascorbic acid oxidase, which comprises an ascorbic acid oxidase being allowed to coexist with nitrous acid or a salt thereof, or a nitrous acid ester in an aqueous medium. The method for stabilizing an ascorbic acid oxidase, the method for preserving an ascorbic acid oxidase, and the stabilized composition of an ascorbic acid oxidase according to the present invention are useful for clinical diagnosis and the like.
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公开(公告)号：EP0506431B1
公开(公告)日：1998-01-28
申请号：EP92302671.0
申请日：1992-03-26
Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD
IPC: C12N9/96
CPC classification number: C12Y110/03003 , C12N9/0046 , C12N9/0063 , C12N9/12 , C12N9/78 , C12N9/96
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6.发明公开Ascorbate oxidase, gene encoding the same, process for producing the same, and reagent composition using the same 失效抗坏血酸氧化酶基因编码它们的制备相同，方法并使用相同的试剂组合物。
公开(公告)号：EP0682116A1
公开(公告)日：1995-11-15
申请号：EP95107149.7
申请日：1995-05-11
Applicant: AMANO PHARMACEUTICAL CO., LTD.
Inventor： Nakanishi, Yuji, c/o Amano Pharm. Co., Ltd., Chuo , Amano, Hitoshi, c/o Amano Pharm. Co., Ltd. , Yamaguchi, Shotaro, c/o Amano Pharm. Co., Ltd.
IPC: C12N15/53 , C12N9/02 , C12N1/15 , A23L3/3571
CPC classification number: C12Y110/03003 , A23L3/3571 , C12N9/0063
Abstract: The present invention provides an ascorbate oxidase (ASOD) which catalyzes oxidation reaction of L-ascorbic acid with molecular oxygen to form L-dehydroascorbic acid and hydrogen peroxide, a process for producing the ascorbate oxidase comprising using a microorganism belonging to the genus Eupenicillium , a gene encoding ASOD, a transformant containing such a gene, a process for producing ASOD using such a transformant, and a reagent composition comprising ASOD, such as a reagent composition for examination, a food additive, and a reagent composition in the fields of food and clinical examination. The ascorbate oxidase has excellent stability particularly in a liquid state.
Abstract translation: 本发明提供了在抗坏血酸氧化酶（ASOD）其催化L-抗坏血酸的氧化反应与分子氧，以形成L-脱氢抗坏血酸和过氧化氢，其制备抗坏血酸氧化酶使用属于杆菌属的微生物的方法，包括正青霉，一个 基因编码ASOD，将含有转化体检查的基因，对于使用寻求转化体生产ASOD的方法，以及试剂组合物，其包括ASOD：诸如用于检查的试剂组合物，食品添加剂，并在食品领域的试剂组合物和 临床检查。 的抗坏血酸氧化酶具有优异的稳定性特别是在液体状态。
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公开(公告)号：EP2708223A4
公开(公告)日：2014-11-12
申请号：EP12782916
申请日：2012-05-10
Applicant: AMANO ENZYME INC
Inventor： HIROSE YOSHIHIKO , SATO YUKIHIDE
CPC classification number: A61K8/99 , A61K8/66 , A61Q5/10 , C12N9/001 , C12N9/0057 , C12N9/0059 , C12N9/0061 , C12N9/0063 , C12N9/0071 , C12P13/00 , C12Y103/03005 , C12Y110/03001 , C12Y110/03002 , C12Y110/03003 , C12Y110/03004 , C12Y114/18001 , D06P1/32 , D06P3/14
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8.发明公开Food containing proteinaceous material treated with a transglutaminase and an oxidoreductase 有权含有转谷氨酰胺酶和氧化还原酶处理蛋白质物质的食物
公开(公告)号：EP0963704A3
公开(公告)日：1999-12-22
申请号：EP99110644.4
申请日：1999-06-02
Applicant: Ajinomoto Co., Ltd.
Inventor： Soeda, Takahiko, c/o Ajinomoto Co., Inc. , Yamazaki, Katsutoshi, Food Res. & Devel. Lab. , Sakaguchi, Shoji, Food Res. & Devel. Lab.
CPC classification number: C12Y101/03004 , A21D2/268 , A21D8/042 , A23J3/16 , A23J3/341 , A23J3/346 , A23L7/109 , A23L13/46 , A23L13/74 , A23L15/25 , A23L17/65 , A23L17/70 , A23L29/06 , C12Y110/03003 , C12Y111/01006 , C12Y203/02013
Abstract: Modifying a food containing proteinaceous material, particularly a food material such as wheat flour, fish pastes, poultry and cattle meats, soybean protein and egg white, in an economical, simple manner; and providing to processed foods produced by using such modified food material, excellent effects of modifying the physico-chemical properties due to the TG action, good effects of modifying different properties such as smoothness during swallowing and crispness to the teeth and preferable color and flavor. By treating a proteinaceous material with transglutaminase (TG) and oxidoreductase or by more preferably treating a food protein with at least one of a substrate of the oxidoreductase, milk protein and a thiol group-containing material in addition to the TG and oxidoreductase, an excellent protein-containing food on modification can be provided by overcoming the problems described above.
Abstract translation: 以经济简单的方式改变含有蛋白质物质的食物，特别是食物物质，如小麦粉，鱼糊，家禽肉和牛肉，大豆蛋白和蛋清; 并且提供通过使用这种改性食品材料生产的加工食品，改善由TG作用引起的物理化学性质的优异效果，改善吞咽期间的光滑性和牙齿脆度等不同性质以及优选的颜色和风味的良好效果。 通过用转谷氨酰胺酶（TG）和氧化还原酶处理蛋白质物质，或者更优选用TG和氧化还原酶以外的氧化还原酶，乳蛋白质和含硫醇基材料的底物中的至少一种处理食物蛋白质， 通过克服上述问题可以提供经修饰的含蛋白质食物。
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9.发明公开Food containing proteinaceous material treated with a transglutaminase and an oxidoreductase 有权Proteinhaltiges Lebensmittel，welches mit einer Transglutaminase und einer Oxidoreduktase behandelt wurde
公开(公告)号：EP0963704A2
公开(公告)日：1999-12-15
申请号：EP99110644.4
申请日：1999-06-02
Applicant: Ajinomoto Co., Ltd.
Inventor： Soeda, Takahiko, c/o Ajinomoto Co., Inc. , Yamazaki, Katsutoshi, Food Res. & Devel. Lab. , Sakaguchi, Shoji, Food Res. & Devel. Lab.
CPC classification number: C12Y101/03004 , A21D2/268 , A21D8/042 , A23J3/16 , A23J3/341 , A23J3/346 , A23L7/109 , A23L13/46 , A23L13/74 , A23L15/25 , A23L17/65 , A23L17/70 , A23L29/06 , C12Y110/03003 , C12Y111/01006 , C12Y203/02013
Abstract: Modifying a food containing proteinaceous material, particularly a food material such as wheat flour, fish pastes, poultry and cattle meats, soybean protein and egg white, in an economical, simple manner; and providing to processed foods produced by using such modified food material, excellent effects of modifying the physico-chemical properties due to the TG action, good effects of modifying different properties such as smoothness during swallowing and crispness to the teeth and preferable color and flavor.
By treating a proteinaceous material with transglutaminase (TG) and oxidoreductase or by more preferably treating a food protein with at least one of a substrate of the oxidoreductase, milk protein and a thiol group-containing material in addition to the TG and oxidoreductase, an excellent protein-containing food on modification can be provided by overcoming the problems described above.Abstract translation: 通过用转谷氨酰胺酶（TG）和氧化还原酶处理蛋白质物质，或者除了TG和氧化还原酶之外，还优选用氧化还原酶，乳蛋白和含硫醇基材料的底物中的至少一种处理食品蛋白质，优异的 可以通过克服上述问题来提供修饰的含蛋白质的食品。
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10.发明授权Ascorbate oxidase, gene encoding the same, process for producing the same, and reagent composition using the same 失效抗坏血酸氧化酶基因编码相同，它们的制备方法和使用相同的试剂组合物
公开(公告)号：EP0682116B1
公开(公告)日：1997-12-17
申请号：EP95107149.7
申请日：1995-05-11
Applicant: AMANO PHARMACEUTICAL CO., LTD.
Inventor： Nakanishi, Yuji, c/o Amano Pharm. Co., Ltd., Chuo , Amano, Hitoshi, c/o Amano Pharm. Co., Ltd. , Yamaguchi, Shotaro, c/o Amano Pharm. Co., Ltd.
IPC: C12N15/53 , C12N9/02 , C12N1/15 , A23L3/3571
CPC classification number: C12Y110/03003 , A23L3/3571 , C12N9/0063
