公开(公告)号：EP2338913A1

公开(公告)日：2011-06-29

申请号：EP10158057.9

申请日：1996-12-17

Applicant: The University of Utah Research Foundation ,  Endo Recherche Inc. ,  The Trustees of The University of Pennsylvania ,  HSC Research and Development Limited Partnership

Inventor： Tavtigian, Sean V. ,  Kamb, Alexander ,  Simard, Jacques ,  Couch, Fergus ,  Rommens, Johanna M. ,  Weber, Barbara L.

IPC: C07K14/82 ,  C12Q1/68 ,  G01N33/53 ,  A01K67/027

CPC classification number: C07K14/4703 ,  A61K48/00 ,  Y10S530/828

Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast cancer predisposing gene (BRCA2), some mutant alleles of which cause susceptibility to cancer, in particular breast cancer. More specifically, the invention relates to germline mutations in the BRCA2 gene and their use in the diagnosis of predisposition to breast cancer. The present invention further relates to somatic mutations in the BRCA2 gene in human breast cancer and their use in the diagnosis and prognosis of human breast cancer. Additionally, the invention relates to somatic mutations in the BRCA2 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the ERCA2 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA2 gene for mutations, which are useful for diagnosing the predisposition to breast cancer.

Abstract translation: 本发明一般涉及人类遗传学领域。 具体而言，本发明涉及用于分离和检测人乳腺癌易感基因（BRCA2）的方法和材料，其中一些突变等位基因引起对癌症尤其是乳腺癌的易感性。 更具体地说，本发明涉及BRCA2基因中的种系突变及其在诊断乳腺癌易感性中的用途。 本发明进一步涉及人乳腺癌中BRCA2基因的体细胞突变及其在人乳腺癌的诊断和预后中的用途。 此外，本发明涉及其他人类癌症中BRCA2基因的体细胞突变及其在人类癌症的诊断和预后中的用途。 本发明还涉及在ERCA2基因中具有突变的人类癌症的治疗，包括基因治疗，蛋白质替代疗法和蛋白质模拟物。 本发明还涉及用于癌症治疗的药物的筛选。 最后，本发明涉及BRCA2基因突变的筛选，其可用于诊断乳腺癌倾向。

公开(公告)号：EP0954585B1

公开(公告)日：2009-11-25

申请号：EP97910785.1

申请日：1997-10-01

Applicant: GERON CORPORATION

Inventor： MORIN, Gregg, B. ,  ANDREWS, William, H.

IPC: C12N15/54 ,  C12N9/12 ,  C12Q1/68 ,  C12Q1/48 ,  C12N15/11 ,  C12N15/85 ,  A01K67/027 ,  C07K16/40 ,  A61K38/45 ,  A61K31/70 ,  C12N1/21 ,  C12N1/19

CPC classification number: C12N15/113 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/1241 ,  C12N9/1276 ,  C12N15/1137 ,  C12N2310/15 ,  C12N2310/315 ,  C12Y207/07049 ,  Y10S530/827 ,  Y10S530/828

Abstract: The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.

公开(公告)号：EP1418235A3

公开(公告)日：2004-08-11

申请号：EP04001099.3

申请日：1996-03-28

Applicant: University of Washington

Inventor： Cheever, Martin ,  Disis, Mary L.

IPC: C12N15/12 ,  C07K14/71 ,  C12N15/86

CPC classification number: A61K39/0011 ,  A61K38/00 ,  A61K39/00 ,  C07K7/06 ,  C07K14/4705 ,  C07K14/71 ,  G01N33/57407 ,  G01N33/57488 ,  G01N2333/71 ,  G01N2333/82 ,  Y10S530/806 ,  Y10S530/828

Abstract: Compounds and compositions for eliciting or enhancing immune reactivity to HER-2/ neu protein are disclosed. The compounds include polypeptides and nucleic acid molecules encoding such peptides. The compounds may be used for the prevention or treatment of malignancies in which the HER-2/ neu oncogene is associated.

公开(公告)号：EP1260520A3

公开(公告)日：2002-12-04

申请号：EP02006768.2

申请日：1996-12-17

Applicant: MYRIAD GENETICS, INC. ,  Endo Recherche Inc. ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  HSC Research and Development Limited Partnership

Inventor： Tavtigian, Sean V. ,  Kamb, Alexander ,  Simard, Jacques ,  Couch, Fergus ,  Rommens, Johanna M. ,  Weber, Barbara L.

IPC: C07K14/82 ,  C12Q1/68 ,  G01N33/53 ,  A01K67/027

CPC classification number: C07K14/4703 ,  A61K48/00 ,  Y10S530/828

Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast cancer predisposing gene (BRCA2), some mutant alleles of which cause susceptibility to cancer, in particular breast cancer. More specifically, the invention relates to germline mutations in the BRCA2 gene and their use in the diagnosis of predisposition to breast cancer. The present invention further relates to somatic mutations in the BRCA2 gene in human breast cancer and their use in the diagnosis and prognosis of human breast cancer. Additionally, the invention relates to somatic mutations in the BRCA2 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA2 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA2 gene for mutations, which are useful for diagnosing the predisposition to breast cancer.

公开(公告)号：EP0831904A4

公开(公告)日：2002-09-18

申请号：EP96916937

申请日：1996-06-03

Applicant: CORNELL RES FOUNDATION INC

Inventor： BANDER NEIL H

IPC: C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K49/00 ,  A61K51/00 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/574 ,  C12N5/20 ,  G01N33/53

CPC classification number: G01N33/57434 ,  A61K38/00 ,  C07K16/28 ,  Y10S436/813 ,  Y10S530/827 ,  Y10S530/828 ,  Y10S530/834 ,  Y10S530/85 ,  Y10S530/861 ,  Y10S530/863

公开(公告)号：EP1224216A1

公开(公告)日：2002-07-24

申请号：EP00942795.6

申请日：2000-06-14

Applicant: LUDWIG INSTITUTE FOR CANCER RESEARCH

Inventor： VAN SNICK, Jacques ,  LETHE, Bernard ,  CHAUX, Pascal ,  BOON-FALLEUR, Thierry ,  VAN DER BRUGGEN, Pierre

IPC: C07K14/47 ,  C07K14/705 ,  C07K7/08 ,  C12N15/62 ,  A61K38/17 ,  G01N33/53 ,  C07K16/18 ,  A61K35/14 ,  C12N5/06

CPC classification number: C07K14/4748 ,  A61K38/00 ,  C07K2319/00 ,  Y10S514/885 ,  Y10S530/806 ,  Y10S530/828

Abstract: The invention describes HLA class II binding peptides encoded by the MAGE-A1 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-A1 gene.

公开(公告)号：EP0904279A4

公开(公告)日：2002-05-08

申请号：EP97902057

申请日：1997-01-17

Applicant: UNIV JOHNS HOPKINS MED

Inventor： KERN SCOTT E ,  HAHN STEPHAN A

IPC: A61K38/00 ,  C07K14/47 ,  C12N1/21 ,  C12N15/63 ,  A61K48/00 ,  C07K14/435 ,  C07K16/00 ,  C12N15/85 ,  C12P19/34 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53

CPC classification number: C07K14/4703 ,  A61K38/00 ,  Y10S435/81 ,  Y10S436/813 ,  Y10S530/828

公开(公告)号：EP1192253A1

公开(公告)日：2002-04-03

申请号：EP00945990.0

申请日：2000-06-22

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LARECHERCHE MEDICALE (INSERM)

Inventor： BRONNER, Christian ,  HOPFNER, Rapha[l ,  MOUSLI, Marc ,  JELTSCH, Jean-Marc ,  LUTZ, Yves ,  OUDET, Pierre

IPC: C12N15/12 ,  C07K14/435 ,  C07K14/47 ,  C12N15/10 ,  C12N15/66 ,  C12N15/11 ,  C12Q1/68 ,  C07K16/18 ,  G01N33/53 ,  A61K51/00 ,  A61P35/00

CPC classification number: C07K16/18 ,  A61K38/00 ,  A61K47/6843 ,  A61K48/00 ,  C12Q1/6886 ,  C12Q2600/136 ,  Y10S530/827 ,  Y10S530/828

Abstract: The invention concerns a novel ICBP90 (Inverted CCAAT box binding protein 90) and its fragments, polynucleotides coding for said polypeptides and specific antibodies directed against said polypeptides. The invention also concerns methods and kits for diagnosing cell proliferation and compounds useful as medicine for preventing and/or treating pathology involving cell proliferation and in particular cancer.

公开(公告)号：EP1159411A1

公开(公告)日：2001-12-05

申请号：EP00905737.3

申请日：2000-01-26

Applicant: Hybritech Incorporated

Inventor： MIKOLAJCZYK, Stephen ,  SAEDI, Mohammad

IPC: C12N9/64 ,  C07K14/81 ,  C07K16/40 ,  C07K16/38 ,  G01N33/573 ,  G01N33/574 ,  G01N33/68 ,  C12Q1/37

CPC classification number: C12N9/6445 ,  C07K14/8121 ,  Y10S436/803 ,  Y10S530/828

Abstract: The present invention provides a novel complex of hK2 and PI-6 and methods of using the novel complex. The novel complexes of hK2 and PI-6 of the present invention exist at an elevated level in prostat cancer tissues. Therefore, the hK2-PI6 complexes of the present invention may be used as a serum marker for detecting prostate cancer. They may also be used as an immunohistological marker to detect prostate cancer tissues. In accordance with the present invention, the hK2-PI6 complexes of the present invention may be detected in patient tissue samples by immunohistochemical and/or in patient fluid samples by in vitro immunoassay procedures. Diagnostic kits and diagnostic methods for detecting the existence of prostate cancer are also provided.

公开(公告)号：EP0661061B1

公开(公告)日：2001-11-07

申请号：EP94203736.7

申请日：1994-12-22

Applicant: Centro de Inmunologia Molecular

Inventor： Rodriguez, Rolando Pérez ,  Molina, Luis Enrique Fernandéz ,  Rodriguéz, Gilda Marquina ,  Pérez, Adriana C., Lacret No. 155 e/ Heredia ,  Hernandéz, Oscar Gonzalo Valiente

IPC: A61K47/48 ,  A61K39/00 ,  A61K39/385 ,  A61K31/70

CPC classification number: A61K31/70 ,  A61K39/00 ,  A61K47/646 ,  A61K2039/6068 ,  A61K2039/627 ,  C07K16/30 ,  Y10S514/885 ,  Y10S530/806 ,  Y10S530/828