公开(公告)号：EP2687278A1

公开(公告)日：2014-01-22

申请号：EP13176179.3

申请日：2013-07-11

Applicant: Kabushiki Kaisha Toshiba

Inventor： WATANDO, Hiroko ,  KUBOKI, Takashi

IPC: B01D15/00 ,  B01J39/02 ,  B01J20/04 ,  B01D53/14

CPC classification number: G01N30/96 ,  B01D15/00 ,  B01D53/1418 ,  B01D53/1475 ,  B01J39/17 ,  B01J49/06 ,  B01J49/53 ,  B01J49/60 ,  C07C213/10 ,  C07C241/00 ,  Y02C10/06 ,  Y02C10/08 ,  Y10T436/147777 ,  Y10T436/170769 ,  Y10T436/173845

Abstract: The objects of embodiments in the present disclosure are to provide a method capable of recovering two or more amine compounds at the same time from a gas or solution, and also to provide a method capable of analyzing the recovered amines.
The amine-recovering method comprises the steps (A) and (B). In the step (A), the gas or solution is brought into contact with a solid adsorbent so that the adsorbent may retain the amines. In the step (B), the amines retained by the adsorbent in the step (A) are eluted out by use of a basic compound-containing organic solvent. The solid adsorbent has a substituent group represented by -SO 3 M (M is H or an alkali metal).

Abstract translation: 本公开的实施方案的目的是提供能够从气体或溶液中同时回收两种或更多种胺化合物的方法，并且还提供能够分析回收的胺的方法。 胺回收方法包括步骤（A）和（B）。 在步骤（A）中，使气体或溶液与固体吸附剂接触，使得吸附剂可以保留胺。 在步骤（B）中，通过使用含碱性化合物的有机溶剂洗脱由步骤（A）中的吸附剂保留的胺。 固体吸附剂具有由-SO 3 M（M为H或碱金属）表示的取代基。

公开(公告)号：EP0920624A1

公开(公告)日：1999-06-09

申请号：EP97934013.0

申请日：1997-06-24

Applicant: NANOGEN, INC.

Inventor： KOVACS, Gregory, T., A.

IPC: B01J19 ,  G01N27 ,  G01N33

CPC classification number: G01N33/5438 ,  B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00722 ,  G01N27/27 ,  G01N27/3276 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/144444 ,  Y10T436/17 ,  Y10T436/170769 ,  Y10T436/171538 ,  Y10T436/173845 ,  Y10T436/20 ,  Y10T436/200833 ,  Y10T436/203332

Abstract: An improved biologic electrode array (12) and methods for using the same. Each electrode (30) in the array (12) is coupled to a respective sample-and-hold circuit (26). The electrodes (30) and sample-and-hold circuits (26) are integral and form an array (12) within a single semiconductor chip, such that each sample-and-hold circuit (26) may be loaded (37) with a predefined voltage provided by a single, time-shared digital-to-analog converter (DAC) (22). All of the sample-and-hold circuits (26) may be accessed through a multiplexer which may scan through some or all of the electrode locations (30). Each sample-and-hold circuit (26) may comprise a capacitor (32) and one or more transistor switches (34, 36), the switches (34, 36), when closed providing electrical communication between the capacitor (32) and a source line (37) formed in the matrix (12).

公开(公告)号：EP0591511A4

公开(公告)日：1994-08-17

申请号：EP93910720

申请日：1993-04-21

Applicant: BRIGHAM & WOMENS HOSPITAL

Inventor： STAMLER JONATHAN ,  LOSCALZO JOSEPH

IPC: G01N21/76 ,  G01N21/63 ,  G01N30/74 ,  G01N30/84 ,  G01N30/88 ,  G01N33/52 ,  G01N33/68

CPC classification number: G01N30/84 ,  G01N21/631 ,  G01N30/74 ,  G01N33/68 ,  G01N2030/8441 ,  G01N2030/8813 ,  G01N2030/8831 ,  Y10T436/17 ,  Y10T436/170769 ,  Y10T436/176152 ,  Y10T436/177692 ,  G01N21/76

Abstract: Nitric oxide, nitrosonium, S-nitrosothiols, and S-nitroso-proteins can be detected in biological samples, using a method which involves injection of samples into a photolysis cell, prior to detection of chemiluminescence generated by the reaction between nitric oxide and ozone. To detect S-nitrosothiols and S-nitroso-proteins separate aliquots of the same samples are subjected to pretreatment with mercurous ion, and a protein-precipitating agent, respectively, and the resulting nitric oxide signals are compared to those generated by untreated samples. This method is useful for monitoring the levels of nitric oxide bioactivity in both normal physiological states, and disease states, such as septic shock, atherosclerosis, thrombosis, hyperhomocysteinemia, pulmonary hypertension, malignancy, infections and central nervous systems disorders.

公开(公告)号：EP2809666B1

公开(公告)日：2018-10-10

申请号：EP13742931.2

申请日：2013-01-30

Applicant: The University of Hong Kong

Inventor： YANG, Dan ,  PENG, Tao ,  SHEN, Jiangang ,  CHEN, Xingmiao

IPC: C07D407/02 ,  C09K3/00 ,  B41M5/327 ,  B41M5/20 ,  C07D311/82 ,  C07D311/90 ,  C07D491/052 ,  C07F9/6561 ,  C07D493/10 ,  C07D493/20 ,  C09B11/08 ,  C09B11/24 ,  C09B69/00 ,  G01N31/22 ,  G01N33/84 ,  C07F7/08

CPC classification number: G01N31/227 ,  C07D311/82 ,  C07D311/90 ,  C07D491/052 ,  C07D493/10 ,  C07D493/20 ,  C07F7/0816 ,  C07F7/2208 ,  C07F7/30 ,  C07F9/6561 ,  C09B11/08 ,  C09B11/24 ,  C09B11/245 ,  C09B69/008 ,  G01N33/582 ,  G01N33/84 ,  Y10T436/170769

Abstract: Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening peroxynitrite. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining peroxynitrite in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of peroxynitrite in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite in chemical and biological samples.

公开(公告)号：EP2687278B1

公开(公告)日：2018-05-30

申请号：EP13176179.3

申请日：2013-07-11

Applicant: Kabushiki Kaisha Toshiba

Inventor： WATANDO, Hiroko ,  KUBOKI, Takashi

IPC: B01D15/00 ,  B01J39/02 ,  B01D53/14 ,  B01J20/04 ,  B01J39/17 ,  B01J49/06 ,  B01J49/53 ,  B01J49/60

CPC classification number: G01N30/96 ,  B01D15/00 ,  B01D53/1418 ,  B01D53/1475 ,  B01J39/17 ,  B01J49/06 ,  B01J49/53 ,  B01J49/60 ,  C07C213/10 ,  C07C241/00 ,  Y02C10/06 ,  Y02C10/08 ,  Y10T436/147777 ,  Y10T436/170769 ,  Y10T436/173845

Abstract: The objects of embodiments in the present disclosure are to provide a method capable of recovering two or more amine compounds at the same time from a gas or solution, and also to provide a method capable of analyzing the recovered amines. The amine-recovering method comprises the steps (A) and (B). In the step (A), the gas or solution is brought into contact with a solid adsorbent so that the adsorbent may retain the amines. In the step (B), the amines retained by the adsorbent in the step (A) are eluted out by use of a basic compound-containing organic solvent. The solid adsorbent has a substituent group represented by -SO 3 M (M is H or an alkali metal).

公开(公告)号：EP2809666A1

公开(公告)日：2014-12-10

申请号：EP13742931.2

申请日：2013-01-30

Applicant: The University of Hong Kong

Inventor： YANG, Dan ,  PENG, Tao ,  SHEN, Jiangang ,  CHEN, Xingmiao

IPC: C07D407/02 ,  C09K3/00 ,  B41M5/327 ,  B41M5/20

CPC classification number: G01N31/227 ,  C07D311/82 ,  C07D311/90 ,  C07D491/052 ,  C07D493/10 ,  C07D493/20 ,  C07F7/0816 ,  C07F9/6561 ,  C09B11/08 ,  C09B11/24 ,  C09B11/245 ,  C09B69/008 ,  G01N33/582 ,  G01N33/84 ,  Y10T436/170769

Abstract: Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening peroxynitrite. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining peroxynitrite in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of peroxynitrite in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite in chemical and biological samples.

Abstract translation: 本文提供了可用作测量，检测和/或筛选过氧亚硝酸盐的试剂的改进的荧光化合物和探针。 本发明的荧光化合物可以产生荧光颜色，例如绿色，黄色，红色或远红色。 本文还提供了用于在活细胞线粒体中选择性染色过氧亚硝酸盐的荧光化合物。 本文还提供了可用于直接或间接测量化学样品和生物样品（例如活生物体中的细胞和组织）中过氧亚硝酸盐的存在和/或量的方法。 还提供了用于检测或筛选过氧亚硝酸盐或可以增加或降低化学和生物样品中过氧亚硝酸盐水平的化合物的高通量筛选方法。

公开(公告)号：EP1766076A4

公开(公告)日：2010-04-07

申请号：EP05762180

申请日：2005-06-09

Applicant: PERKINELMER LAS INC

Inventor： BOSSE ROGER ,  PATTON WAYNE F ,  ROBY PHILIPPE

IPC: G01N33/20 ,  C12Q1/68 ,  G01N33/68

CPC classification number: G01N33/6842 ,  Y10T436/16 ,  Y10T436/163333 ,  Y10T436/166666 ,  Y10T436/17 ,  Y10T436/170769 ,  Y10T436/176152 ,  Y10T436/176921 ,  Y10T436/18 ,  Y10T436/182 ,  Y10T436/188 ,  Y10T436/24

公开(公告)号：EP1817363B1

公开(公告)日：2010-01-06

申请号：EP05810748.3

申请日：2005-10-03

Applicant: Commissariat à l'Energie Atomique

Inventor： POULLAIN, Didier ,  PASQUINET, Eric ,  HAIRAULT, Lionel

IPC: C08G77/04 ,  C08G77/26 ,  C08G77/388 ,  G01N27/00

CPC classification number: C08G77/045 ,  C08G77/26 ,  C08G77/388 ,  G01N27/126 ,  G01N29/036 ,  G01N33/0057 ,  G01N2291/0257 ,  Y10T436/17 ,  Y10T436/170769 ,  Y10T436/173076 ,  Y10T436/173845

Abstract: The invention concerns chemical sensors comprising aniline polysiloxanes as sensitive materials, and use thereof for detecting or assaying nitro compounds, in particular nitroaromatic compounds. The invention is useful for detecting explosives, controlling and monitoring atmospheric pollution and the quality of more or less confined atmospheres, surveillance of industrial sites.

公开(公告)号：EP0920624A4

公开(公告)日：2002-04-17

申请号：EP97934013

申请日：1997-06-24

Applicant: NANOGEN INC

Inventor： KOVACS GREGORY T A

IPC: B01J19/00 ,  G01N27/00 ,  G01N27/327 ,  G01N27/403 ,  G01N33/543 ,  C12Q1/68 ,  G01N21/75 ,  G01N27/07

CPC classification number: G01N33/5438 ,  B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00722 ,  G01N27/27 ,  G01N27/3276 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/144444 ,  Y10T436/17 ,  Y10T436/170769 ,  Y10T436/171538 ,  Y10T436/173845 ,  Y10T436/20 ,  Y10T436/200833 ,  Y10T436/203332

Abstract: An improved biologic electrode array (12) and methods for using the same. Each electrode (30) in the array (12) is coupled to a respective sample-and-hold circuit (26). The electrodes (30) and sample-and-hold circuits (26) are integral and form an array (12) within a single semiconductor chip, such that each sample-and-hold circuit (26) may be loaded (37) with a predefined voltage provided by a single, time-shared digital-to-analog converter (DAC) (22). All of the sample-and-hold circuits (26) may be accessed through a multiplexer which may scan through some or all of the electrode locations (30). Each sample-and-hold circuit (26) may comprise a capacitor (32) and one or more transistor switches (34, 36), the switches (34, 36), when closed providing electrical communication between the capacitor (32) and a source line (37) formed in the matrix (12).

公开(公告)号：EP1996919B1

公开(公告)日：2011-11-02

申请号：EP07840142.9

申请日：2007-03-12

Applicant: University of Florida Research Foundation, Incorporated

Inventor： HUMMEL, Rolf, E. ,  FULLER, Ann, Marie ,  SCHOLLHORN, Dr. Claus ,  HOLLOWAY, Paul, H.

IPC: G01N21/31 ,  G01N21/55 ,  G01N33/22

CPC classification number: G01N21/31 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/55 ,  G01N33/227 ,  G01N2001/022 ,  G01N2021/1793 ,  G01N2021/3133 ,  Y10T436/170769 ,  Y10T436/173076

Abstract: A system and method for identifying explosive or other target materials includes the steps of irradiating a first location and a second location spaced apart from the first location from a sample suspected of including explosives with ultraviolet, visible or infrared light, measuring reflected light emanated from the first sample location (R1) and reflected light emanated from the second sample location (R2), and calculating a normalized difference in reflectivity (ΔR/ R ), wherein R = (R1+R2)/2 is an average reflectivity. A differential reflection spectrum (DRS) is then generated for the sample where ΔR=R2-R1 is the difference of the reflectivities of the first and the second sample location. One or more explosives or other target materials if present are identified in the sample based on comparing the DRS for the sample to at least one reference DRS.