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1.发明公开公开(公告)号：EP3878837A1
公开(公告)日：2021-09-15
申请号：EP20162558.9
申请日：2020-03-11
Applicant: OM Pharma SA
Inventor： BAUER, Jacques , MARTIN, Olivier
IPC: C07C235/64 , C07C66/00 , C07C229/38 , C07C233/51 , C07C275/42 , C07C309/51 , C07C317/46 , C07C323/56 , C07D213/79 , C07D235/18 , C07D257/04 , A61K31/196 , A61P3/00 , A61P35/00 , A61P37/00
Abstract: The invention provides hydroquinone derivatives of formula (I), processes of preparation, as well as pharmaceutical compositions and methods of treating and/or preventing e.g. autoimmune, immunological, rheumatology, vascular, ophthalmologic, fibrotic, metabolic and gastro-intestinal disorders, neuroinflammatory and neurodegenerative diseases, neoplasms and cancer associated disorders, hormone related diseases and immunological disorders resulting from viral and bacterial infectious diseases and complications thereof.
wherein: R a , R b = H, acyl or aryl alkyl; R 1 = COOR 4 , (CH 2 ) n COOR 4 , SO 3 H, (CH 2 ) n SO 3 H or CONH-R 10 ; R 2 and R 3 = H or R 5 , with the proviso that when one of R 2 and R 3 is R 5 , the other is H; R 4 = H, alkyl or aryl alkyl; R 5 = R 6 , R 7 or R 8 ; R 6 = CONH-R 9 , CONHCOR 9 , CONH(CH 2 ) n - R 9 , CONHCH(COOR 4 )(CH 2 ) k R 9 or heteroaryl-R 9 ; k = 0-4; R 7 = optionally substituted benzoheteroaryl ; R 8 = (CH 2 ) m X(CH 2 ) p R 9 ; X = O, S, SO 2 , NH, NAc or N(CH 2 ) q R 9 ; R 9 = optionally substituted aryl, heteroaryl or cycloalkyl ; R 10 = optionally substituted aryl or heteroaryl ; n, m, p and q = independently 1-4.
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2.发明公开
公开(公告)号：EP3336078A1
公开(公告)日：2018-06-20
申请号：EP17200696.7
申请日：2004-02-09
Applicant: Shenzhen Chipscreen Biosciences Ltd.
Inventor： Lu, Xian-Ping , Li, Zhibin , Xie, Aihua , Li, Boyu , Ning, Zhiqiang , Shan, Song , Deng, Tuo , Hu, Weiming , Shi, Leming
IPC: C07D213/56 , C07C233/51 , C07C237/42 , A61K31/4406 , A61K31/165 , A61P17/06 , A61P35/00
CPC classification number: C07D213/56 , A61P17/06 , A61P35/00 , C07C233/51 , C07C237/42
Abstract: The present invention is related to the preparation and pharmaceutical use of novel benzamide derivatives as defined in the specification of formula (I) as histone deacetylase inhibitors (HDACI), their preparations and the methods of using these compounds or their pharmaceutically acceptable salt in the treatment of cell proliferative diseases, e.g. cancer and psoriasis.
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3.发明授权OMEGA-AMINOALKYLAMIDES OF (R)-2-ARYL-PROPIONIC ACIDS AS INHIBITORS OF THE CHEMOTAXIS OF POLYMORPHONUCLEATE AND MONONUCLEATE CELLS 有权作者（R）-2-芳基丙酸AS多形AND MONONUCLEATEN细胞的趋化性的抑制剂OMEGA氨基烷基
公开(公告)号：EP1366018B1
公开(公告)日：2016-07-06
申请号：EP02744900.8
申请日：2002-02-25
Applicant: Dompé farmaceutici s.p.a.
Inventor： ALLEGRETTI, Marcello , BERTINI, Riccardo , BERDINI, Valerio , BIZZARRI, Cinzia , CESTA, Maria, Candida , DI CIOCCIO, Vito , CASELLI, Gianfranco , COLOTTA, Francesco , GANDOLFI, Carmelo
IPC: C07C233/40 , C07C233/51 , C07C233/44 , C07C235/34 , C07C235/70 , C07C237/22 , C07C279/12 , C07C281/16 , C07C231/02 , C07C231/16 , C07D211/06 , C07D211/58 , C07D233/48 , C07D239/14 , C07D295/13 , C07D471/08 , C07D233/24 , C07D233/46 , A61K31/165
CPC classification number: C07C233/51 , A61K31/165 , A61K31/198 , A61K31/445 , A61K31/4453 , A61K31/5375 , C07B2200/07 , C07C231/02 , C07C231/16 , C07C233/40 , C07C233/44 , C07C235/34 , C07C235/70 , C07C235/78 , C07C237/20 , C07C237/22 , C07C279/12 , C07C281/16 , C07D211/04 , C07D211/58 , C07D233/24 , C07D233/46 , C07D295/13 , C07D451/04
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4.发明公开AN ENZYMATIC ROUTE FOR THE PREPARATION OF CHIRAL y-ARYL- beta-AMINOBUTYRIC ACID DERIVATIVES 有权用于制备手性γ-芳基-β-氨基丁酸衍生物的酶促途径
公开(公告)号：EP2935205A1
公开(公告)日：2015-10-28
申请号：EP13818745.5
申请日：2013-12-20
Applicant: LEK Pharmaceuticals d.d.
Inventor： STARCEVIC, Stefan , MRAK, Peter , KOPITAR, Gregor
IPC: C07C233/51 , C12P13/04
CPC classification number: C12P41/007 , A61K31/4985 , A61K45/06 , C07B2200/07 , C07C231/18 , C07C233/51 , C12P13/04
Abstract: The present invention relates to a process for preparing chiral γ-aryl-β-aminobutyric acid compounds and derivatives thereof.
Abstract translation: 本发明涉及制备手性γ-芳基-β-氨基丁酸化合物及其衍生物的方法。
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公开(公告)号：EP2268606B1
公开(公告)日：2014-08-06
申请号：EP09738022.4
申请日：2009-04-20
Applicant: F. Hoffmann-La Roche AG
Inventor： ANDJELKOVIC, Mirjana , CECCARELLI, Simona M. , CHOMIENNE, Odile , KAPLAN, Gerald Lewis , MATTEI, Patrizio , TILLEY, Jefferson Wright
IPC: C07C233/51 , C07C235/12 , C07C235/20 , C07C237/12 , C07C275/16 , C07D213/55 , C07D277/30 , C07D333/24 , A61K31/197 , A61K31/426 , A61K31/381 , A61K31/4406 , A61P9/12 , A61P3/06 , A61P3/08
CPC classification number: C07D213/56 , C07C237/12 , C07C275/16 , C07C317/44 , C07D277/30 , C07D333/24
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公开(公告)号：EP2622970A4
公开(公告)日：2014-04-16
申请号：EP10857834
申请日：2010-09-29
Applicant: AJINOMOTO KK
Inventor： AMINO YUSUKE , MAEKAWA TAKAMI , ETO YUZURU , KANEKO MEGUMI , TAHARA YUKI , MIYAKI TAKASHI , SAIKAWA WAKANA , KAI YUKO , ISHIWATARI YUTAKA
IPC: A23L27/00 , A23L27/10 , A23L27/40 , C07C233/29 , C07C233/51 , C07C233/87 , C07C309/46 , C07D209/14 , C07D209/18 , C07D209/20 , C07D317/48 , C07D487/04
CPC classification number: C07D209/14 , A23L27/204 , A23L27/2054 , A23L27/88 , C07C233/51 , C07C235/38 , C07C235/60 , C07C237/20 , C07C309/51 , C07D209/16 , C07D209/18 , C07D209/20 , C07D317/48 , C07D317/60 , C07D487/04
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公开(公告)号：EP2622970A1
公开(公告)日：2013-08-07
申请号：EP10857834.5
申请日：2010-09-29
Applicant: Ajinomoto Co., Inc.
Inventor： AMINO, Yusuke , MAEKAWA, Takami , ETO, Yuzuru , KANEKO, Megumi , TAHARA, Yuki , MIYAKI, Takashi , SAIKAWA, Wakana , KAI, Yuko , ISHIWATARI, Yutaka
IPC: A23L1/22 , A23L1/237 , C07C233/29 , C07C233/51 , C07C233/87 , C07C309/46 , C07D209/14 , C07D209/18 , C07D209/20 , C07D317/48 , C07D487/04
CPC classification number: C07D209/14 , A23L27/204 , A23L27/2054 , A23L27/88 , C07C233/51 , C07C235/38 , C07C235/60 , C07C237/20 , C07C309/51 , C07D209/16 , C07D209/18 , C07D209/20 , C07D317/48 , C07D317/60 , C07D487/04
Abstract: The present invention provides a compound having a salty taste enhance activity, and a salty taste enhancer comprising the compound, and the like.
The present invention relates to a salty taste enhancer for food and drink which comprises a compound represented by the following formula:
wherein each symbol is as defined in the specification, or an edible salt thereof.Abstract translation: 本发明提供了具有咸味增强活性的化合物和包含该化合物的咸味增强剂等。 本发明涉及一种食品和饮料的咸味增强剂，其包含由下式表示的化合物：其中每个符号如说明书中所定义，或其食用盐。
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8.发明公开PROCESS FOR MANUFACTURE OF N-ACYLBPHENYL ALANINE 有权VERFAHREN ZUR HERSTELLUNG VON N-ACYL-B-PHENYL-ALANIN
公开(公告)号：EP2480523A4
公开(公告)日：2013-06-26
申请号：EP10818263
申请日：2010-03-23
Applicant: ZHEJIANG JIUZHOU PHARM CO LTD , NOVARTIS AG
Inventor： ZHU GUOLIANG , SHI DESONG , WEI JUNHUI , TAO FENGFENG
IPC: C07C231/12 , C07C233/47 , C07C233/51 , C07D263/18
CPC classification number: C07C233/47 , C07C233/51 , C07C233/83 , C07C233/87 , C07D263/20
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公开(公告)号：EP2599767A1
公开(公告)日：2013-06-05
申请号：EP11010059.1
申请日：2011-12-21
Applicant: Lunamed AG
Inventor： Truog, Peter , Buschmann, Helmut H.
IPC: C07C69/14 , C07C69/612 , C07C69/86 , C07C229/36 , C07C233/51 , A61K31/216
CPC classification number: C07C69/157 , C07C69/612 , C07C69/86 , C07C229/36 , C07C233/51
Abstract: The present invention refers to derivatives of formula (I), wherein R 4 , R 5 , Y, and n are defined in claim 1, their stereoisomers as well as the acids, bases or salts thereof, medicaments comprising them, as well as said compounds for use in cancer therapy and other phamaceutical applications.
Abstract translation: 本发明涉及式（I）的衍生物，其中R 4，R 5，Y和n如权利要求1所定义，其立体异构体以及其酸，碱或盐，包含它们的药物以及所述 用于癌症治疗和其他药物应用的化合物。
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公开(公告)号：EP2480523A1
公开(公告)日：2012-08-01
申请号：EP10818263.5
申请日：2010-03-23
Applicant: Zhejiang Jiuzhou Pharmaceutical Co., Ltd. , Novartis AG
Inventor： ZHU, Guoliang , SHI, Desong , WEI, Junhui , TAO, Fengfeng
IPC: C07C231/12 , C07C233/47 , C07C233/51 , C07D263/18
CPC classification number: C07C233/47 , C07C233/51 , C07C233/83 , C07C233/87 , C07D263/20
Abstract: A novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.
