公开(公告)号：EP2240788B1

公开(公告)日：2018-06-27

申请号：EP09707598.0

申请日：2009-02-05

Applicant: Hydro-Québec

Inventor： COUTURE, Pierre ,  DUVAL, Michel

IPC: G01R31/00 ,  C07C317/26 ,  C07C245/12 ,  C07K14/76 ,  G01K7/42

CPC classification number: G01K7/42

公开(公告)号：EP2240788A1

公开(公告)日：2010-10-20

申请号：EP09707598.0

申请日：2009-02-05

Applicant: Hydro-Québec

Inventor： COUTURE, Pierre ,  DUVAL, Michel

IPC: G01R31/00 ,  C07C317/26 ,  C07C245/12 ,  C07K14/76

CPC classification number: G01K7/42

Abstract: The invention relates to a method for measuring the real temperature of a hot spot in an oil-containing electric apparatus, such as a power transformer. The electric apparatus is operated in predetermined and changeable operating conditions. The method comprises using one or more chemical compounds or tracers present and soluble in the oil. Each tracer is capable of conversion at a given temperature in order to form a residue such as a soluble gas. Due to the presence of residue in the oil, the operator can determine in which predetermined operational conditions the hot spot has been reached, and derive therefrom the hot spot for a given condition. The different compounds used include diazoic compounds, carbonyl metals, dyes, pigments, liquid crystals or albumins. The method can also be used for checking the quality of the marketed apparatus and estimating the lifespan thereof.

公开(公告)号：EP1879859A2

公开(公告)日：2008-01-23

申请号：EP06770422.1

申请日：2006-05-12

Applicant: Wyeth

Inventor： GOPALSAMY, Ariamala ,  MOORE, William, Jay ,  KERN, Jeffery, Curtis ,  MOLINARI, Albert, John ,  SHI, Mengxiao ,  WELMAKER, Gregory, Scott ,  WILSON, Matthew, Allan ,  KRISHNAMURTHY, Girija ,  COMMONS, Thomas, Joseph ,  WEBB, Michael, Byron ,  WOODWORTH, Richard, P.

IPC: C07C317/20 ,  C07C317/22 ,  C07C317/26 ,  C07C317/38 ,  A61K31/445

CPC classification number: C07F9/3882 ,  C07C317/14 ,  C07C317/22 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D213/42 ,  C07D233/54 ,  C07D401/04 ,  C07F9/4056

Abstract: Compounds of Formula (I), or pharmaceutically acceptable salts thereof, are provided, which are modulators of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety of disorders, including osteoporosis.

Abstract translation: 提供式1化合物或其药学上可接受的盐：其是分泌的卷曲相关蛋白-1的调节剂。 化合物和含有这些化合物的组合物可用于治疗多种疾病，包括骨质疏松症。

公开(公告)号：EP1282694A4

公开(公告)日：2005-10-26

申请号：EP01927162

申请日：2001-04-18

Applicant: SUPERGEN INC ,  UNIV WICHITA STATE

Inventor： GROUTAS WILLIAM C

IPC: C07C307/06 ,  C12N9/99 ,  A61K31/18 ,  C07C317/26 ,  C12N9/48 ,  C12N9/50

CPC classification number: C07C307/06 ,  Y02P20/55

公开(公告)号：EP0625508B1

公开(公告)日：1998-08-19

申请号：EP94107448.6

申请日：1994-05-13

Applicant: RHONE POULENC AGRICULTURE LTD.

Inventor： Cramp, Susan Mary, Rhone Poulenc ,  Wallis, Derek Ian, Rhone Poulenc ,  Lambert, Claude ,  Yarwood, Thomas David, Rhone Poulenc

IPC: C07C323/32 ,  C07C317/26 ,  A01N31/08 ,  A01N37/34 ,  A01N41/10

CPC classification number: C07C317/44 ,  A01N37/42 ,  A01N41/10 ,  C07C323/62 ,  C07C2601/02

公开(公告)号：EP4251142A1

公开(公告)日：2023-10-04

申请号：EP21899205.5

申请日：2021-11-30

Applicant: Sophrosyne Pharmaceuticals Limited

Inventor： FELDBERG, Lewis ,  SABOUNI, Akram ,  BAILEY, Thomas R. ,  TAI, Vincent Wing-Fai

IPC: A61K31/10 ,  C07C317/24 ,  C07C317/26 ,  A61P25/32

公开(公告)号：EP3390355B1

公开(公告)日：2022-12-28

申请号：EP17707787.2

申请日：2017-02-21

Inventor： GIULIANO, Claudio ,  DAINA, Antoine ,  PIETRA, Claudio

IPC: C07C311/00 ,  C07D239/26 ,  C07C317/14 ,  C07C317/26 ,  C07D209/04

公开(公告)号：EP1341534A4

公开(公告)日：2005-09-28

申请号：EP01989756

申请日：2001-11-16

Applicant: DOW AGROSCIENCES LLC

Inventor： RICKS MICHAEL JOHN ,  KLITTICH CARLA JEAN RASMUSSEN ,  CETUSIC JEANNIE RACHEL PHILLIP ,  IAMAUTI MARILENE TENGUAN ,  MORRISON IRENE MAE ,  SULLENBERGER MICHAEL THOMAS ,  LO WILLIAM CHI-LEUNG ,  BUYSSE ANN MARIE ,  RIEDER BRENT RIEDER ,  MATHIESON JOHN TODD ,  OLSON MONICA BRITT

IPC: C07D333/38 ,  A01N47/12 ,  A01N47/30 ,  C07C315/00 ,  C07C317/26 ,  C07C317/28 ,  C07C317/44 ,  C07D213/61 ,  C07D277/64 ,  A61K31/21 ,  A61K31/17 ,  A61K31/275 ,  A61K31/343 ,  A61K31/44 ,  C07C255/50 ,  C07C275/06 ,  C07C275/28 ,  C07C309/04 ,  C07C317/04

CPC classification number: C07C317/28 ,  C07C317/44

Abstract: A compound according to formula one that is useful as a fungicide is provided. Additionally, processes to make and use same are provided.

公开(公告)号：EP0786457A4

公开(公告)日：1997-12-29

申请号：EP95934280

申请日：1995-10-12

Applicant: YAMANOUCHI PHARMA CO LTD

Inventor： NAGAOKA HITOSHI ,  YOKOTA MASAKI ,  AKANE HIROAKI ,  ARAKIDA YASUHITO ,  ISOMURA YASUO

IPC: A61K31/427 ,  A61P9/10 ,  A61P37/08 ,  C07C317/26 ,  C07D263/56 ,  C07D277/24 ,  C07D277/26 ,  C07D277/30 ,  C07D277/34 ,  C07D277/36 ,  C07D277/60 ,  C07D277/64 ,  C07D413/12 ,  C07D417/12 ,  C07D263/32 ,  C07D263/38 ,  C07D263/46 ,  C07D263/52 ,  C07D263/58

CPC classification number: C07D263/56 ,  C07D277/24 ,  C07D277/26 ,  C07D277/30 ,  C07D277/36 ,  C07D277/64 ,  C07D413/12 ,  C07D417/12

Abstract: An azole derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, having both of a leukotriene antagonistic effect and a thromboxane A2 antagonistic effect and being useful in preventing or treating allergic diseases, ischemic heart diseases or ischemic brain diseases, and a medicinal composition containing the same as the active ingredient, wherein R?1 and R2¿ may be the same or different and represent each hydrogen, cycloalkyl, etc., or R?1 and R2¿ together with (a) may form a fused ring (b) or (c) which may be substituted by optionally substituted lower alkyl, amino, etc.; R?3, R6, R7 and R8¿ may be the same or different and represent each hydrogen, amino, etc.; R4 represents cyano, tetrazolyl, -COOR9, etc.; R5 represents hydrogen or lower alkyl; D represents optionally substituted lower alkylene; X and Z may be the same or different and represent each oxygen or sulfur; Y represents -N= or -CH=; A represents -O-B-, -B-O-, -S-B-, -B-S- or -B- (B being lower alkylene or lower alkenylene); and n is 0, 1 or 2.

公开(公告)号：EP0664786A4

公开(公告)日：1995-11-02

申请号：EP93924369

申请日：1993-10-18

Applicant: CORVAS INT INC

Inventor： WEBB THOMAS ROY ,  MILLER TODD ANTHONY ,  VLASUK GEORGE PHILLIP ,  ABELMAN MATTHEW MARK

IPC: A61K38/55 ,  A61K31/195 ,  A61K31/198 ,  A61K31/695 ,  A61K38/00 ,  A61K38/06 ,  A61P7/02 ,  C07C279/12 ,  C07C279/36 ,  C07C307/02 ,  C07C307/06 ,  C07C307/08 ,  C07C307/10 ,  C07C311/06 ,  C07C311/13 ,  C07C311/19 ,  C07C317/26 ,  C07D207/16 ,  C07D211/60 ,  C07D257/04 ,  C07D403/06 ,  C07D403/12 ,  C07F7/10 ,  C07K5/06 ,  C07K5/068 ,  C07K5/072 ,  C07K5/078 ,  C07K5/083 ,  C07K5/093 ,  C07K5/097 ,  C07K5/113 ,  C07K14/75 ,  C07C69/76 ,  C07C233/00 ,  C07C303/00

CPC classification number: C07D207/16 ,  A61K38/00 ,  C07D211/60 ,  C07D257/04 ,  C07K5/0606 ,  C07K5/06086 ,  C07K5/06113 ,  C07K5/06139 ,  C07K5/06165 ,  C07K5/0806 ,  C07K5/081 ,  C07K5/0819 ,  C07K5/1021 ,  C07K14/75 ,  Y10S514/822

Abstract: The present invention is directed to novel arginine alpha-keto-amide derivatives, their pharmaceutically acceptable salts and compositions thereof which are useful as antithrombotic agents in mammals and also the use of these compounds as antithrombotic agents. Also, described are methods of using these inhibitors as inhibitors of coagulation proteases and as therapeutic agents for disease states characterized by abnormal thrombus formation and/or disorders of the blood coagulation process. Further described herein are compounds useful as intermediates in the preparation of thesse compounds.

Abstract translation: 本发明涉及可用作哺乳动物抗血栓形成剂的新型精氨酸α-酮酰胺衍生物，其药学上可接受的盐和组合物，以及这些化合物作为抗血栓形成剂的用途。 而且，描述了使用这些抑制剂作为凝血蛋白酶抑制剂和作为治疗剂用于以异常血栓形成和/或凝血过程紊乱为特征的疾病状态的方法。 本文进一步描述的是用作制备这些化合物的中间体的化合物。