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公开(公告)号：EP4309670A3
公开(公告)日：2024-07-17
申请号：EP23214012.9
申请日：2017-09-01
申请人： Sanofi Pasteur, Inc.
IPC分类号： A61K39/095
CPC分类号： A61K2039/5558320130101 , A61K2039/603720130101 , A61K2039/7020130101 , A61K39/095 , A61P31/04 , A61P37/04 , Y02A50/30
摘要： Provided herein are compounds, compositions, formulations, kits, uses, and methods for vaccinating a subject against Neisseria meningitidis.
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公开(公告)号：EP3501534B1
公开(公告)日：2023-11-29
申请号：EP18209661.0
申请日：2009-10-26
发明人： EXLEY, Rachel , TANG, Christoph , LEA, Susan, M.
IPC分类号： A61K39/095
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3.发明公开
公开(公告)号：EP4173634A1
公开(公告)日：2023-05-03
申请号：EP21758042.2
申请日：2021-06-28
申请人： INSTITUTO BUTANTAN
IPC分类号： A61K39/00 , C12N1/00 , A61K39/095
摘要： The present invention refers to a process for obtaining antigen-presenting vesicles (APV) that enables the coupling of one or more antigens, wherein such APV comprises (i) an outer membrane vesicle of gram-negative bacteria (OMV); (ii) at least one antigenic protein or peptide; and (iii) at least a pair of molecules with complementary affinities comprising a first affinity molecule that associates with the vesicle, and a complementary affinity molecule that associates with the protein or peptide. Thus, the process for obtaining the APV of the present invention is essential to achieve a form of presentation that consists of a vesicle that makes it possible to attach one or more proteins, or a plurality of different protein or peptide antigens. In that regard, such process comprises the following steps: (a) conjugating the first affinity molecule to the vesicle (OMV); (b) obtaining the antigen protein(s) or peptide(s) in fusion with the complementary affinity molecule; and (c) coupling the fusion protein obtained in step "b" with the product obtained in step "a".
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公开(公告)号：EP4043029A1
公开(公告)日：2022-08-17
申请号：EP22154276.4
申请日：2013-03-06
申请人： Pfizer Inc.
发明人： ANDERSON, Annaliesa Sybil , HOISETH, Susan Kay , JANSEN, Kathrin Ute , MORAN, Justin Keith , RUPPEN, Mark E.
IPC分类号： A61K39/095 , C07K16/12 , C07K14/22 , A61P31/04 , A61P37/04
摘要： The invention relates to variants of the 2086 lipoprotein from Neisseria meningitidis, also known as factor H binding protein (fHBP) or ORF2086, in particular to an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 68 and, to immunogenic compositions comprising such polypeptide variant, especially non-lipidated, non-pyruvylated forms thereof.
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公开(公告)号：EP4036104A1
公开(公告)日：2022-08-03
申请号：EP22155506.3
申请日：2011-03-29
摘要： Factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of N. meningitidis, and methods of use of such proteins are provided.
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公开(公告)号：EP3172224B1
公开(公告)日：2022-06-29
申请号：EP15824545.6
申请日：2015-07-22
发明人： BEERNINK, Peter T.
IPC分类号： C07K14/22 , A61P31/04 , A61P37/04 , A61K39/095 , A61K39/00
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公开(公告)号：EP3997108A1
公开(公告)日：2022-05-18
申请号：EP20836204.6
申请日：2020-07-08
申请人： Crapaud Bio, Inc.
发明人： GRIFFISS, J. McLeod
IPC分类号： C07K14/22 , A61K39/095 , A61P31/04
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公开(公告)号：EP3009146B1
公开(公告)日：2021-10-20
申请号：EP15189397.1
申请日：2006-06-23
发明人： BIEMANS, Ralph, Leon , BOUTRIAU, Dominique , CAPIAU, Carine , DENOEL, Philippe , DUVIVIER, Pierre , POOLMAN, Jan
IPC分类号： A61K39/385 , A61K39/095 , A61K39/102 , A61K39/116 , A61P31/04 , A61K39/00
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公开(公告)号：EP2861247B1
公开(公告)日：2020-12-09
申请号：EP13747515.8
申请日：2013-06-14
发明人： PIZZA, Mariagrazia , DULL, Peter , GIULIANI, Marzia Monica , TAHA, Muhamed-Kheir , HONG, Eva , DEGHMANE, Ala-Eddine
IPC分类号： A61K39/095 , A61P31/04
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