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    PROCESS OF PRODUCING A HIGHLY ABSORBENT HYDROGEL COMPOSITION FOR MEDICAL PURPOSES, IN PARTICULAR FOR WOUND TREATMENT
    5.
    发明公开
    PROCESS OF PRODUCING A HIGHLY ABSORBENT HYDROGEL COMPOSITION FOR MEDICAL PURPOSES, IN PARTICULAR FOR WOUND TREATMENT 审中-公开

    公开(公告)号：EP4338762A1

    公开(公告)日：2024-03-20

    申请号：EP22195761.6

    申请日：2022-09-15

    申请人： Paul Hartmann AG

    发明人： KETTEL, Markus ,  BASTIDA AGOTE, Nora

    IPC分类号： A61L15/60 ,  A61L15/24 ,  A61L15/26 ,  A61L15/42

    摘要： The present invention relates to a process of producing a composition for medical purposes, in particular for wound treatment, comprising the steps of:
    i. preparing a mixture comprising a superabsorbent polymer, an isocyanate-terminated prepolymer and water,
    ii. allowing the prepolymer to react with one or more components of the mixture to obtain the composition,
    wherein the superabsorbent polymer is a cross-linked polyacrylate and wherein the isocyanate-terminated prepolymer contains polyalkylene oxide units and is a branched molecule having at least three arms. Moreover, the present invention relates to the composition obtainable by the aforementioned process. Use of said composition in medicine and as wound dressing material is also a subject of the present invention. For example, the composition may be used as an atraumatic wound contact layer, which may absorb excess moisture from the wound and release moisture to the wound as required. Thereby, the composition may create a moist wound environment supporting the healing process and may effectively prevent maceration and drying of the wound. In particular, the composition may have a high absorption capacity.

    MEDICAL HYDROGEL AND PREPARATION METHOD THEREFOR AND USE THEREOF
    8.
    发明公开
    MEDICAL HYDROGEL AND PREPARATION METHOD THEREFOR AND USE THEREOF 审中-公开

    公开(公告)号：EP4252787A1

    公开(公告)日：2023-10-04

    申请号：EP21936605.1

    申请日：2021-06-10

    申请人： Beijing Biosis Healing Biological Technology Co., Ltd.

    发明人： ZHAO, Bo ,  WEI, Pengfei ,  ZHAO, Wei ,  JING, Wei ,  XIA, Leilei ,  ZHAO, Yanrui

    IPC分类号： A61L24/04 ,  A61L15/24 ,  C09J171/02

    摘要： The present disclosure pertains to the field of biomedical materials, and in particular relates to a medical hydrogel, a preparation method and uses thereof, and a kit for preparing the medical hydrogel. The medical hydrogel of the present disclosure comprises a hydrogel skeleton, and a chelating agent chelated to the hydrogel skeleton; wherein the hydrogel skeleton comprises a polymer that is formed by the bonding of a polyethylene glycol derivative I having a structure shown in Formula (I) and a polyethylene glycol derivative II having a structure shown in Formula (II) and has multiple "long arms". After tannic acid and/or citric acid as a chelating agent chelates with the hydrogel skeleton, a medical hydrogel can be obtained, which has good bacteriostatic properties, mechanical properties, adhesion properties, low swelling properties, and controllable gel formation rate and degradation rate. Moreover, the hydrogel is able to maintain viscosity in a wet state without being affected by body fluids, and it can still ensure effective adhesion and closure of wounds if there is movement or pulsation of the tissue, thus having great clinical application prospects.