公开(公告)号：JPH09243630A

公开(公告)日：1997-09-19

申请号：JP5202396

申请日：1996-03-08

Applicant: HOECHST JAPAN

Inventor： MOTOSUGI KENJI ,  TAKANO YUSUKE

IPC: G01N21/41 ,  G01N21/47 ,  G01N33/00 ,  G01N33/28

Abstract: PROBLEM TO BE SOLVED: To provide a small-sized org. gas kind discrimination apparatus high in safety. SOLUTION: (M) detection units 21-2n are arranged along a vapor passage 1 through which arbitrary fuel vapor among (m) kinds (m>=2) of fuel vapors is passed. The light source part 21E of each detection unit irradiates a sensor member 21S showing inherent reflecting characteristics to one of (m) kinds of different fuel vapors through a first optical fiber 21F1 . The reflected light from the sensor member 21S is received by a second optical fiber 21F2 and the signal having the magnitude corresponding to the intensity thereof is outputted from a detection part. A signal processing part 3 compares these signals to discriminate what is the fuel vapor introduced into the fuel vapor passage 1.

公开(公告)号：JPH09241178A

公开(公告)日：1997-09-16

申请号：JP5001196

申请日：1996-03-07

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD ,  HOECHST JAPAN

Inventor： IGARI YASUTAKA ,  BUTANI TOSHIRO ,  IINUMA SATOSHI

IPC: A61K9/52 ,  A61K38/35 ,  A61K47/10 ,  A61K47/34 ,  A61P5/38 ,  A61P25/18 ,  A61P25/28 ,  C07K7/06 ,  C07K14/575 ,  C08L67/00 ,  C08L67/04

Abstract: PROBLEM TO BE SOLVED: To obtain the subject preparation capable of carrying out longterm zero-dimensional release of an adrenocorticotropic hormone derivative useful as a peptide of psychotropic nerve action by using a drying method in water from an emulsion using lactic acid-glycolic acid having a composition ratio in a specific range and a weight-average molecular weight in a specific range. SOLUTION: A W/O type emulsion using (A) a solution or a dispersion containing an adrenocorticotropic hormone derivative [preferably L-methionyl-L- glutamyl-L-histidyl-L-phenylalanyl-D-lysyl-N-(8-aminooctyl)-L-phenylal anineamide- S, S-dioxide] or its salt (preferably acetic salt) as an inner water phase and using (B) a solution containing an in vivo degradable polymer having a free carboxyl group at the end as an oil phase is prepared. Then, the resultant emulsion is dispersed into an outer water phase to prepare a W/0/W type emulsion, which is then dried by drying in water. Furthermore, the outer water phase contains preferably 0.1-60(W/V)% osmotic pressure adjuster (preferably mannitol).

公开(公告)号：JPH09110787A

公开(公告)日：1997-04-28

申请号：JP29790495

申请日：1995-10-11

Applicant: HOECHST JAPAN

Inventor： HAGIWARA HISAHIRO

IPC: C07C67/18 ,  C07C69/14 ,  C07C69/157

Abstract: PROBLEM TO BE SOLVED: To simply and profitably obtain an acetate ester useful as a synthetic raw material or intermediate for medicines and various compounds by reacting an specific OH group-containing compound with acetylimidazole in the absence of a solvent in a high selectivity and in a high yield with scarcely polluting an environment. SOLUTION: (A) A primary alcohol or a phenolic OH group-having compound is reacted with (B) acetylimidazole e.g. in an A/B molar ratio of 1/(1-2.2), especially 1/(1.2-2.2), in an opened air atmosphere at a temperature of -30 to 100 deg.C, especially 10-40 deg.C, to produce an acetic ester. When the component A is solid, the components A and B are concretely sufficiently ground with a mortar, etc., and subsequently leave them in stationary state for their reaction.

公开(公告)号：JPH08333390A

公开(公告)日：1996-12-17

申请号：JP34464995

申请日：1995-11-24

Applicant: HOECHST JAPAN

Inventor： YAMAGATA NOBUYUKI ,  OGATA KENJI ,  WAGATSUMA MASAKO ,  TAKANASHI HITOSHI

IPC: A61K38/00 ,  A61P29/00 ,  C07K7/06 ,  C07K14/705

Abstract: PURPOSE: To obtain a new peptide (derivative) little in side effects such as antigenicity, having an immunodepressive activity non-specific to antigens, and useful for medicines for treating autoimmune diseases such as multiple sclerosis. CONSTITUTION: A peptide having an amino acid sequence of formula: Ala-Lys- Leu-Thr-Phe-Gly-Lys-Gly-Thr, or its derivative. The peptide (derivative) is obtained e.g. by subjecting amino acids, whose N-terminals are protected with 9-fluorenylmethyloxycarbonyl groups, to mutual coupling reactions on p- hydroxymethyloxycarbonylpolystyrene resin.

公开(公告)号：JPH08262019A

公开(公告)日：1996-10-11

申请号：JP6035595

申请日：1995-03-20

Applicant: HOECHST JAPAN

Inventor： AKITA MIKIO ,  TANAKA SHIGEAKI ,  OGAMI HIROYUKI

IPC: G01N33/53

Abstract: PURPOSE: To obtain a diagnostic agent by which osteoporosis due to an autoimmunity can be detected, by which osteoporosis can be diagnosed at an early stage and by which a part of cryptogenic osteoporosis can be classified on the assumption that the cryptogenic osteoporosis is an autoimmune disease- related disease. CONSTITUTION: The diagnostic agent of osteoporosis due to an autoimmunity is composed of a monoclonal antibody which specifically recognizes a human bone-specific sialoprotein or a polyclonal anitbody against the human bone- specific sialoprotein. The diagnostic agent is brought into contact with a body fluid sample, e.g. a serum, which has been sampled from a human being, and a soluble immune complex which is formed of the human bone-specific sialoprotein existing in the sample and of an auto-antibody which reacts specifically with the sialoprotein is detected immunochemically by using the diagnostic agent.

公开(公告)号：JPH08231513A

公开(公告)日：1996-09-10

申请号：JP7808195

申请日：1995-02-27

Applicant: HOECHST JAPAN

Inventor： HAGIWARA HISAHIRO

IPC: C07D233/60

Abstract: PURPOSE: To obtain the subject compound useful as an intermediate for medicines, agrochemicals, etc., by a simple and mild reaction operation comprising reacting a hydroxyl group-containing compound with thiocarbonyldiimidazole in a specific ratio. CONSTITUTION: A hydroxyl group-containing compound of the formula: R-OH (R is an organic residue) is mixed and reacted with thiocarbonyldiimidazole of formula I in a molar ratio of 1:(1-1.8), preferably 1:(1.2-1.6), in the absence of a solvent under non-heating to obtain the objective compound of formula II.

公开(公告)号：JPH08184560A

公开(公告)日：1996-07-16

申请号：JP32828194

申请日：1994-12-28

Applicant: HOECHST JAPAN

Inventor： YUAN RIU ,  MOTOSUGI KENJI ,  YAMAMOTO SATORU ,  KURISUTOFU ROOTO ,  ARAI MASAYUKI ,  HANSUUURURITSUHI SHIMUROTSUKU

IPC: G01N21/27 ,  G01N21/45 ,  G01N21/77

Abstract: PURPOSE: To obtain a highly reliable portable optical sensor for detecting vapor of organic solvent having a simple structure which can be manufactured easily at a low cost while reducing the size thereof. CONSTITUTION: The optical sensor OS comprises a light source section 2 and a thin polymer membrane 10 formed on the flat reflection board 8 of a sensing element 6 is irradiated with light emitted from the light source section 2. The light reflected on the sensing element 6 is detected at a light detecting section 4. The light source section 2, the sensing element 6 and the light detecting section 4 are supported integrally on a housing 12. When the thin polymer membrane 10 touches vapor of organic solvent, at least the thickness of the membrane 10 is varied. Variation of thickness is utilized in the detection of presence and/or concentration of vapor of organic solvent.

公开(公告)号：JPH08176191A

公开(公告)日：1996-07-09

申请号：JP20017595

申请日：1995-07-04

Applicant: HOECHST JAPAN

Inventor： KURITA TAKASHI ,  MATSUMOTO TOMOAKI ,  KIKUNO REIKO ,  HAMAMOTO YOKO ,  GERUHARUDO BURAIPOORU

IPC: A61K38/00 ,  A61P3/00 ,  A61P9/10 ,  A61P43/00 ,  C07K7/08 ,  C07K14/51 ,  C07K19/00

Abstract: PURPOSE: To obtain a new synthetic peptide derivative having a specific amino acid sequence, manifesting a bone-inducing factor antagonist-like activity and effective for suppressing symptoms of bone-metabolic disease accompanying ectopic ossification or calcinosis and useful for a therapeutic medicine of arteriosclerosis or ectopic ossifying disease, etc. CONSTITUTION: This new synthetic peptide derivative is expressed by the formula: P -R -P [P is a peptide having an amino acid sequence expressed by formula I or its analog; P is a peptide having an amino acid sequence expressed by formula II or its analog; R is a linker composed of an organic group having carboxyl groups on both ends and connectable to N-ends of peptides expressed by formula III or formula IV, etc. (R is a 1-6C alkylene, a 6-9C cycloalkylalkylene or a 7-9C phenylalkylene; R is H, an alkyl or an aryl, etc.)], manifesting a bone-inducing factor antagonist-like activity and effective for suppressing symptoms of bone-metabolic disease accompanying ectopic ossification or calcinosis and useful for a therapeutic or preventing medicine, etc., of arteriosclerosis or ectopic ossifying disease, etc.

公开(公告)号：JPH08131949A

公开(公告)日：1996-05-28

申请号：JP28038194

申请日：1994-11-15

Applicant: HOECHST JAPAN

Inventor： MURATA MAKOTO ,  ITO HIROMI

IPC: B05D3/04 ,  B05D7/24 ,  C08G73/18

Abstract: PURPOSE: To improve the chemical resistance and surface hardness of polybenzimidazole by forming a coating of a polybenzimidazole solution on a substrate and baking the coating at a specified temperature in an oxidizing atmosphere. CONSTITUTION: At the time of formation of a polybenzimidazole coating suitably used as a heat resistant coating material for electric wires, etc., after a coating of a polybenzimidazole solution is formed on a substrate, the coating is baked at 300-550 deg.C in an oxidizing atmosphere. As a result, a polybenzimidazole coating with remarkably improved chemical resistance and surface hardness is obtained. A substance expressed by the general formula (n in the formula stands for 2 or higher integer) is used as the polybenzimidazole and, if necessary, an additive filler or a binder resin substance is added to the polybenzimidazole solution.

公开(公告)号：JPH08129260A

公开(公告)日：1996-05-21

申请号：JP26957994

申请日：1994-11-02

Applicant: HOECHST JAPAN

Inventor： MUNIRACHIYUNA PADOMANABAN ,  SUEHIRO NATSUMI ,  KINOSHITA YOSHIAKI ,  FUNATO SATORU ,  MASUDA SEIYA ,  OKAZAKI HIROSHI ,  GEORUGU PAUROUSUKI

IPC: G03F7/00 ,  G03F7/004 ,  G03F7/033 ,  G03F7/039 ,  G03F7/085 ,  H01L21/027

Abstract: PURPOSE: To improve adhesion to a substrate, to extend processing latitude and to enable development with an aq. alkali soln. by incorporating a binder, a dissolution inhibitor, a photosensitive compd., a base, etc., specified respectively. CONSTITUTION: This radiation sensitive compsn. contains a binder insoluble in water but soluble or swellable in an aq. alkali soln., a dissolut. inhibitor, a photosensitive compd. which generates an acid by exposure with active radiation, a base which is degraded to a neutral compd. by the same exposure and a phenolic compd. represented by the formula (where R is 1-12C alkyl, etc., and A is a 1-100C alicyclic group). The dissolution inhibitor is made of poly(N,O- acetal) represented by the formula (-CHR -O-R -X-NR -)p (where R is alkyl, aryl, etc., R is divalent alkylene, cycloalkylene, etc., R is alkyl, alkene, etc., and X is -OCO-, -CO-, etc.) and/or a phenolic compd. having a hydroxyl group protected with a group which is cleaved by an acid.