ANORECTIC AGENT
    97.
    发明专利

    公开(公告)号:JP2002104975A

    公开(公告)日:2002-04-10

    申请号:JP2000298955

    申请日:2000-09-29

    摘要: PROBLEM TO BE SOLVED: To obtain a medicine usable for amelioration and prophylaxis of obesity and highly excellent in safety, or a healthy food or the like or a food and drink having the excellent effects. SOLUTION: This anorectic agent is characterized by comprising a low- molecular chitosan or a derivative thereof having a weight-average molecular weight within the range of 80,000-110,000, preferably 90,000-100,000 and a number- average molecular weight within the range of 30,000-50,000, preferably 30,000-40,000 measured by GPC. The healthy food and drink contains the low- molecular chitosan or the derivative thereof.

    REMEDY FOR BACTERIAL SHOCK
    100.
    发明专利

    公开(公告)号:JPH0482840A

    公开(公告)日:1992-03-16

    申请号:JP19564490

    申请日:1990-07-24

    摘要: PURPOSE:To obtain an extremely excellent remedy for bacterial shock exhibiting strong antibacterial activity against Gram-negative bacteria and capable of neutralizing the bioactivity of lipid A by using a peptide extracted and separated from limulus as an active component. CONSTITUTION:The objective agent contains, as an active component, either one of peptides of formula I to formula V (the groups (1) and (2) and the groups (3)and (4) are directly bonded with each other; Arg-NH2 shows that carboxyl of arginine is amide form) and their pharmacologically allowable salts. The above peptide bonds to Gram-negative bacterial endotoxin to neutralize its biological effect and is useful as a remedy for Gram-negative bacterial blood disease and bacterial shock. It can be administered orally or parenterally at a rate of 0.1-1,000mg per one dose.