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公开(公告)号：JP4708675B2
公开(公告)日：2011-06-22
申请号：JP2002545135
申请日：2001-11-02
Applicant: プロテオテック・インコーポレーテッド
Inventor： キャスティロ，ジェラルド , グエン，ベス , スノー，アラン・ディー , チョイ，パウラ・ワイ
IPC: A61K31/353 , A61K36/18 , A61K31/215 , A61K31/216 , A61K31/35 , A61K36/00 , A61K36/74 , A61P3/10 , A61P25/00 , A61P25/28 , A61P31/00 , A61P35/00 , A61P43/00 , C12N20060101 , C12N9/99
CPC classification number: A61K36/74 , A61K31/215 , A61K31/353 , A61K2300/00
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公开(公告)号：JP2011516493A
公开(公告)日：2011-05-26
申请号：JP2011503203
申请日：2009-04-03
Applicant: エーザイ・アール・アンド・ディー・マネジメント株式会社
Inventor： フー，ヨンボ
IPC: C07D493/22 , A61K31/35 , A61K45/00 , A61P35/00 , A61P43/00
CPC classification number: C07D493/22 , C07B2200/13
Abstract: 本発明は、薬剤活性を持つハリコンドリンＢ類似体、あるいはそれらの結晶形、ならびに合成中間体としてさらなる有用性を持つハリコンドリンＢ類似体を含む。
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公开(公告)号：JP2011084568A
公开(公告)日：2011-04-28
申请号：JP2010273586
申请日：2010-12-08
Applicant: Elan Pharmaceuticals Inc , Pharmacia & Upjohn Co Llc , イーラン ファーマスーティカルズ、インコーポレイテッド , ファルマシア・アンド・アップジョン・カンパニー・エルエルシー
Inventor： MAILLARD MICHEL , BALDWIN ERIC T , BECK JAMES P , HUGHES ROBERT , JOHN VARGHESE , PULLEY SHON R , TENBRINK RUTH
IPC: C07D335/04 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/18 , A61K31/341 , A61K31/35 , A61K31/353 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/4025 , A61K31/417 , A61K31/4196 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4706 , A61K31/4965 , A61K31/50 , A61K31/505 , A61P25/28 , A61P43/00 , C07C233/05 , C07C233/36 , C07C235/10 , C07C235/74 , C07C271/24 , C07C311/05 , C07C327/30 , C07D213/36 , C07D213/38 , C07D215/22 , C07D215/233 , C07D215/38 , C07D215/42 , C07D215/46 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D277/28 , C07D307/52 , C07D311/04 , C07D311/68 , C07D311/74 , C07D311/76 , C07D333/20 , C07D335/06 , C07D403/04 , C07D495/04
CPC classification number: C07C233/36 , C07C235/10 , C07C235/74 , C07C271/24 , C07C311/05 , C07C327/30 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D209/14 , C07D213/38 , C07D213/64 , C07D215/233 , C07D215/38 , C07D215/42 , C07D215/46 , C07D217/22 , C07D233/61 , C07D233/64 , C07D237/08 , C07D237/14 , C07D239/26 , C07D239/38 , C07D241/12 , C07D249/08 , C07D261/08 , C07D265/02 , C07D277/28 , C07D295/135 , C07D307/52 , C07D309/14 , C07D311/68 , C07D311/74 , C07D333/20 , C07D333/22 , C07D335/06 , C07D405/04 , C07D407/06 , C07D409/12 , C07D495/04
Abstract: PROBLEM TO BE SOLVED: To provide a compound which is an inhibitor for β-secretase enzymes, therefore, useful for the treatment of Alzheimer's dementia and other illness characterized by deposition of A β-peptide in mammals. SOLUTION: This compound is represented by chemical formula shown in the solution, wherein variables Z, X, R 15 , R 2 , R 3 and Rc are defined elsewhere. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 要解决的问题：提供作为β-分泌酶的抑制剂的化合物，因此可用于治疗阿尔茨海默氏痴呆症和以哺乳动物沉积Aβ肽为特征的其他疾病。 解决方案：该化合物由溶液中所示的化学式表示，其中变量Z，X，R 15，R SB 2，R SB 3， SB>和Rc在别处定义。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP4651611B2
公开(公告)日：2011-03-16
申请号：JP2006500456
申请日：2004-01-13
IPC: A61K31/353 , A61K9/08 , A61K9/14 , A61K9/48 , A61K9/72 , A61K31/35 , A61K31/70 , A61K31/7048 , A61K36/75 , A61P11/10 , A61P11/14 , C07D311/32
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55.发明专利
公开(公告)号：JP2011026345A
公开(公告)日：2011-02-10
申请号：JP2010239126
申请日：2010-10-25
Applicant: Oregon Health & Science Univ , Regents Of The Univ Of California , オレゴン ヘルス アンド サイエンス ユニバーシティ , ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents of The University of California
Inventor： SCANLAN THOMAS S , HART MATTHEW E , GRANDY DAVID K , BUNZOW JAMES R
IPC: C07C217/60 , A61K20060101 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/166 , A61K31/277 , A61K31/35 , A61P1/00 , A61P1/04 , A61P3/04 , A61P3/10 , A61P5/14 , A61P5/16 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/06 , A61P19/10 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P29/02 , A61P43/00 , C07C211/27 , C07C215/52 , C07C215/54 , C07C217/20 , C07C233/77 , C07C235/50 , C07C235/60 , C07C323/32
CPC classification number: C07C217/60 , C07C215/52 , C07C217/16 , C07C217/20 , C07C217/54 , C07C235/50 , C07C235/60 , C07C255/37 , C07C271/16 , C07C271/20
Abstract: PROBLEM TO BE SOLVED: To understand non-genome effects relating to a thyroid hormone and to regulate them. SOLUTION: The invention relates, in general, to a thyronamine derivative and thyronamine analog of thyroid hormones, a pharmaceutical composition containing the derivative and analog, a method of producing the derivative and analog, and a method of using them. The pharmaceutical composition includes at lest one pharmaceutically acceptable carrier or a vehicle, and an effective amount of the compounds. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 要解决的问题：了解与甲状腺激素相关的非基因组效应并调节它们。 解决方案：本发明一般涉及甲状腺激素的甲状腺原甲酸衍生物和甲状腺素类似物，含有衍生物和类似物的药物组合物，制备衍生物和类似物的方法及其使用方法。 药物组合物至少包含一种药学上可接受的载体或载体，以及有效量的化合物。 版权所有（C）2011，JPO＆INPIT
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56.发明专利
公开(公告)号：JP2010540601A
公开(公告)日：2010-12-24
申请号：JP2010527494
申请日：2008-10-02
Applicant: ユニヴェルシテ ジョセフ フーリエUniversite Joseph Fourier
Inventor： ウォン，ユン−シン , サイダニ，ナディア , ビアル，アンリ，ジョセフ , プシュムール，マリーヌ，エイミー , ボッテ，シリル , マレシャル，エリック
IPC: C07D493/10 , A61K31/35 , A61P33/02 , A61P33/06 , C07D493/20
CPC classification number: C07D493/10 , A61K31/35 , A61K31/351 , C07D493/20
Abstract: Polyspirane compounds (I) and their salts for the prevention or treatment of disease associated with parasites belonging to apicomplexa phylum, are new. Polyspirane compounds of formula (I) and their salts for the prevention or treatment of disease associated with parasites belonging to apicomplexa phylum, are new. either R 1H; and R 2-CH 2COX-R a; or R 1R 2cyclohexa-2,5-dienone group of formula (G1); X : N, O or C (when X is O, R ais optionally saturated 1-20C alkyl or 3-8C cycloalkyl, when X is CH 2, R ais H, optionally saturated 1-20C alkyl or 3-8C cycloalkyl and when X is N, then N can be monosubstituted by R aor disubstituted by R aand R b); R 3-R 6, R 12, R 13H, optionally saturated 1-6C alkyl, 3-8C cycloalkyl, optionally saturated O-1-6C alkyl, O-3-8C cycloalkyl or halo (comprising Cl, F, Br or I); R 7, R 8H, optionally saturated 1-6C alkyl, 3-8C cycloalkyl, optionally saturated O-1-6C alkyl, O-3-8C cycloalkyl, NH-1-6C alkyl, NH-3-8C cycloalkyl or NHCO-R; R : optionally saturated 1-6C alkyl or 3-8C cycloalkyl; R 10, R 11H, OH, optionally saturated O-1-8C alkyl, O-3-8C cycloalkyl or tertiary amine group; R 9OH, O-allyl, O-benzyl, O-CO-alkyl, O-COCH 2CO-alkyl (where the alkyl group is optionally saturated and has 1-20 C, or the O-CO-cycloalkyl has 3-8 C), optionally saturated 1-20C alkyl, 3-8C cycloalkyl, S(O)-R c, O-alkyl, O-CH 2-CH 2-N(CH 3) 2, O-CH 2-CCH, 1H-[1,2,3]triazole group of formula (a) or NR cR d; R a, R bH, optionally saturated 1-20C alkyl or 3-8C cycloalkyl; R coptionally saturated 1-20C alkyl or 3-8C cycloalkyl; and R doptionally saturated 1-20C alkyl. An independent claim is included for the preparation of (I). [Image] - ACTIVITY : Antiparasitic; Antimalarial; Protozoacide. - MECHANISM OF ACTION : None given.
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公开(公告)号：JP4593880B2
公开(公告)日：2010-12-08
申请号：JP2002589478
申请日：2002-05-16
Applicant: サイトビア インコーポレイテッド
IPC: C07D215/54 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/382 , A61K31/40 , A61K31/4025 , A61K31/407 , A61K31/415 , A61K31/4188 , A61K31/44 , A61K31/453 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5377 , A61K33/24 , A61K45/06 , A61P1/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D311/58 , C07D311/64 , C07D335/06 , C07D405/04 , C07D491/04 , C07D491/052 , C07D493/04 , C07D495/04
CPC classification number: C07D335/06 , A61K31/35 , A61K31/353 , A61K31/38 , A61K31/40 , A61K31/407 , A61K31/415 , A61K31/44 , A61K31/47 , A61K31/495 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/535 , A61K33/24 , A61K45/06 , C07D215/54 , C07D311/58 , C07D311/64 , C07D405/04 , C07D491/04 , C07D493/04 , C07D495/04 , A61K2300/00
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公开(公告)号：JP2010270155A
公开(公告)日：2010-12-02
申请号：JP2010199045
申请日：2010-09-06
Applicant: Gruenenthal Gmbh , グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング
Inventor： HINZE CLAUDIA , AULENBACHER OTTO , SUNDERMANN BERND , OBERBOERSCH STEFAN , FRIDERICHS ELMAR , ENGLBERGER WERNER , KOEGEL BABETTE-YVONNE , LINZ KLAUS , SCHICK HANS , SONNENSCHEIN HELMUT , HENKEL BIRGITTA , ROSE VALERIE SARAH , LIPKIN MICHAEL JONATHAN
IPC: C07D471/10 , A61K31/35 , A61K31/381 , A61K31/382 , A61K31/407 , A61K31/438 , A61P1/12 , A61P1/14 , A61P3/06 , A61P7/00 , A61P7/10 , A61P9/00 , A61P9/02 , A61P9/12 , A61P13/10 , A61P15/10 , A61P17/04 , A61P21/02 , A61P23/02 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/36 , A61P27/16 , C07D491/10 , C07D491/107 , C07D493/10 , C07D495/10
CPC classification number: C07D471/10 , C07C59/255 , C07C59/265 , C07C309/04 , C07C309/06 , C07D491/10 , C07D491/107 , C07D493/10 , C07D495/10
Abstract: PROBLEM TO BE SOLVED: To provide a medicine which acts on nociceptin/ORL1-receptor systems, thereby which is, particularly according to the state of the art, suitable for a therapeutic medicine for various diseases related to these systems, or suitable for use in the indications. SOLUTION: The invention relates to spirocyclic cyclohexane derivatives represented by general formula I and a method for producing them, and can be solved by using the medicine containing the compound and the spirocyclic cyclohexane derivatives for manufacture of the medicine. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 要解决的问题：提供作用于伤害感受肽/ ORL1-受体系统的药物，特别是根据现有技术的，适合于与这些系统相关的各种疾病的治疗药物或适合的药物 用于适应症。 解决方案：本发明涉及由通式I表示的螺环环己烷衍生物及其制备方法，并且可以通过使用含有化合物和螺环己烷衍生物的药物来制备药物来解决。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP4555401B2
公开(公告)日：2010-09-29
申请号：JP51224495
申请日：1994-10-21
Inventor： デルマー，エリック・ジー , ネメス，エドワード・エフ , バランドリン，マニュエル・エフ , バン・ワゲネン，ブラッドフォード・シー , モエ，スコット・ティー
IPC: A61K31/135 , C07C211/27 , A61K20060101 , A61K31/13 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , A61P3/00 , A61P3/14 , A61P9/12 , A61P19/10 , A61P43/00 , C07C20060101 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/50 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/28 , C07C225/16 , C07C229/38 , C07C233/05 , C07C237/30 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/54 , C07D317/58 , C07D319/18 , C07K14/705 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/84
CPC classification number: A61K31/70 , A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07C2601/14 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , G01N2500/10 , G01N2800/04
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公开(公告)号：JP4530307B2
公开(公告)日：2010-08-25
申请号：JP24944699
申请日：1999-09-03
Applicant: 日本水産株式会社
IPC: A23K1/18 , A23K1/16 , A61K31/045 , A61K31/085 , A61K31/11 , A61K31/121 , A61K31/231 , A61K31/35 , A61K31/352 , A61K36/00 , A61P33/00
CPC classification number: A61K31/352 , A23K20/10 , A23K20/105 , A23K20/111 , A23K50/80 , A61K31/045 , A61K31/085 , A61K31/11 , A61K31/121 , A61K31/231 , A61K31/35 , A61K2300/00
