New opiate compound, method of making the same and method of use thereof
    6.
    发明专利
    New opiate compound, method of making the same and method of use thereof 审中-公开
    新型化合物,其制备方法及其使用方法

    公开(公告)号:JP2010095543A

    公开(公告)日:2010-04-30

    申请号:JP2010018782

    申请日:2010-01-29

    CPC classification number: C07D221/22 C07D211/22 C07D211/58 C07D221/08

    Abstract: PROBLEM TO BE SOLVED: To provide a new opiate compound binding to an opioid receptor. SOLUTION: The compound is represented by formula (IV) [wherein, R a and R b are each independently hydrogen or alkyl or R a and R b together form cycloalkyl; Xs are each independently alkyl; O is 5-membered or 6-membered-ring aryl or heteroaryl; Zs are each independently alkyl, -OH, -OR, halogen, -CF 3 , -CN, -NH 2 , -NHR or -N(R) 2 ; when Z is -N(R) 2 , R groups form cycloalkyl; Rs are each independently alkyl, aryl or aralkyl; Ws are each alkyl; n is 0 or an integer of 1-4; y is 0 or an integer of 1-5; z is 0 or an integer of 1-8; and R 5 is alkyl, alkenyl or aralkyl] and a pharmaceutically acceptable salt thereof. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题:提供与阿片受体结合的新的阿片剂化合物。 解决方案:该化合物由式(IV)表示[其中,R SB和R B各自独立地为氢或烷基或R“ SB>和R b 一起形成环烷基; Xs各自独立地为烷基; O是5元或6元环芳基或杂芳基; Zs各自独立地为烷基,-OH,-OR,卤素,-CF 3,-SN,-NH SB 2,-NHR或-N(R) 2 ; 当Z为-N(R) 2 时,R基团形成环烷基; R 5各自独立地为烷基,芳基或芳烷基; W均为烷基; n为0或1-4的整数; y为0或1-5的整数; z为0或1-8的整数; 和R“SB”是烷基,烯基或芳烷基]及其药学上可接受的盐。 版权所有(C)2010,JPO&INPIT

    Microelectromechanical system valve and its manufacturing method
    10.
    发明专利
    Microelectromechanical system valve and its manufacturing method 有权
    微电子系统阀及其制造方法

    公开(公告)号:JP2007321986A

    公开(公告)日:2007-12-13

    申请号:JP2007197284

    申请日:2007-07-30

    Abstract: PROBLEM TO BE SOLVED: To provide a microelectromechanical system (MEMS) valve device having advantages of quick operation, large valve force and large displacement while consuming minimal power. SOLUTION: The MEMS valve device includes a substrate 20 having an aperture 70 formed therein, a substrate electrode 40, and a movable membrane 60 located on the aperture 70 and having an electrode element layer 62 and biasing element layers 64, 66. At least one resiliently compressible dielectric layer 50 is provided to ensure electrical isolation between the substrate electrode 40 and the electrode element layer 62 of the movable membrane 60. In operation, voltage difference is established between the substrate electrode 40 and the electrode element layer 62 of the movable membrane 60 to move the movable membrane 60 relative to the aperture 70 to thereby controllably adjust the portion of the aperture 70 covered with the movable membrane 60. COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题:提供一种微机电系统(MEMS)阀装置,其具有快速操作,大阀力和大排量的优点,同时消耗最小的功率。 解决方案:MEMS阀装置包括其中形成有孔70的基板20,基板电极40和位于孔70上并具有电极元件层62和偏压元件层64,66的可移动膜60。 提供至少一个可弹性压缩介电层50以确保基板电极40和可移动膜60的电极元件层62之间的电隔离。在操作中,在基板电极40和电极元件层62之间建立电压差 移动膜60相对于孔70移动可移动膜60,从而可控地调节被可移动膜60覆盖的孔70的部分。版权所有(C)2008,JPO&INPIT

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