公开(公告)号：US07453535B2

公开(公告)日：2008-11-18

申请号：US11115283

申请日：2005-04-27

申请人： Akinori Sumi

发明人： Akinori Sumi

IPC分类号： G02F1/1333

CPC分类号： G02F1/133512 ,  G02F1/134363

摘要： A liquid crystal device includes a first substrate, a second substrate arranged oppositely to the first substrate, and a liquid crystal layer sandwiched between the first and second substrates. Preferably, the first substrate includes a gate wiring, a gate terminal part formed at an end of the first substrate and provided with a gate terminal to which a signal to the gate wiring is inputted, a source wiring intersecting with the gate wiring through an insulating film, a switching element connected to the source wiring, a pixel electrode connected to the source wiring through the switching element, and a common electrode arranged oppositely to the pixel electrode. Preferably, the second substrate includes a light shielding film formed on the side of the first substrate and arranged at a position corresponding to the gate wiring, and a cutting where the light shielding film is cut in a pixel near the gate terminal part.

摘要翻译： 液晶装置包括第一基板，与第一基板相对布置的第二基板和夹在第一和第二基板之间的液晶层。 优选地，第一基板包括栅极布线，栅极端子部分，形成在第一基板的端部处并且设置有栅极端子，栅极端子输入到栅极布线的信号;源极布线，其通过绝缘体与栅极布线相交 连接到源极布线的开关元件，通过开关元件连接到源极布线的像素电极，以及与像素电极相对布置的公共电极。 优选地，第二基板包括形成在第一基板侧并且布置在对应于栅极布线的位置处的遮光膜，以及在栅极端子部分附近的像素中切割遮光膜的切割。

公开(公告)号：US06717629B2

公开(公告)日：2004-04-06

申请号：US10283206

申请日：2002-10-30

申请人： Akinori Sumi ,  Ichiro Takasaki ,  Miyuki Hirosue

发明人： Akinori Sumi ,  Ichiro Takasaki ,  Miyuki Hirosue

IPC分类号： G02F11333

CPC分类号： G02F1/136204 ,  G02F1/1345

摘要： In a process for chamfering substrates constituting a liquid crystal display device, it is made possible to prevent a static electricity from generating in a chamfering amount mark used in order to perform a highly accurate chamfering, and improve a chamfering accuracy. There is provided a structure in which a chamfering amount mark 7 formed in an end portion of a 1st substrate is formed so as to be electrically connected to a short wiring 10, and a connection between the chamfering amount mark 7 and extension wirings 9 which are another conductive wirings is performed, thereby discharging the static electricity to another conductive pattern. Incidentally, there is adopted a structure in which plural mark patterns 8b constituting the chamfering amount mark 7 are intended to be electrically connected by a connecting wiring 8a and, additionally, the connecting wiring 8a is extended to a short wiring 10 side.

摘要翻译： 在构成液晶显示装置的基板的倒角加工方法中，为了进行高精度的倒角，能够防止以所使用的倒角量标记产生静电，提高倒角精度。 提供一种结构，其中形成在第一基板的端部中的倒角量标记7形成为电连接到短布线10，并且倒角量标记7和延伸布线9之间的连接是 执行另一导电布线，从而将静电放电到另一导电图案。 顺便提及，采用构成倒角量标记7的多个标记图案8b通过连接布线8a电连接的结构，另外，连接布线8a延伸到短布线10侧。

公开(公告)号：US06617133B1

公开(公告)日：2003-09-09

申请号：US09317214

申请日：1999-05-24

申请人： Munehiro Noda ,  Akinori Sumi ,  Takao Ohmura ,  Kazumasa Yokoyama

发明人： Munehiro Noda ,  Akinori Sumi ,  Takao Ohmura ,  Kazumasa Yokoyama

IPC分类号： C12P2100

CPC分类号： C07K14/765

摘要： The invention provides a process for purifying recombinant human serum albumin (rHSA) by heating a-culture medium containing rHSA and the rHSA-producing host cells, feeding said heated solution upwardly into a fluidized bed in which adsorbent particles are suspended to effect contacting with the adsorbent particles and then recovering the adsorbed fraction containing the rHSA, and a composition comprising rHSA which shows a A350/A280 ratio of below 0.015, when formulated into a 25% solution of said albumin.

摘要翻译： 本发明提供了通过加热含有rHSA和产生rHSA的宿主细胞的培养基来纯化重组人血清白蛋白（rHSA）的方法，将所述加热溶液向上加入流化床中，其中吸附剂颗粒悬浮以实现与 吸附剂颗粒，然后回收含有rHSA的吸附级分，以及包含rHSA的组合物，其在配制成所述白蛋白的25％溶液时显示A350 / A280比率低于0.015。

公开(公告)号：US5962649A

公开(公告)日：1999-10-05

申请号：US522089

申请日：1995-08-31

申请人： Munehiro Noda ,  Akinori Sumi ,  Takao Ohmura ,  Kazumasa Yokoyama

发明人： Munehiro Noda ,  Akinori Sumi ,  Takao Ohmura ,  Kazumasa Yokoyama

IPC分类号： C07K14/765 ,  C07K1/16

CPC分类号： C07K14/765

摘要： The invention provides a process for purifying recombinant human serum albumin (rHSA) by heating a culture medium containing rHSA and the rHSA-producing host cello, feeding said heated solution upwardly into a fluidized bed in which adsorbent particles are suspended to effect contacting with the adsorbent particles and then recovering the adsorbed fraction containing the rHSA, and a composition comprising rHSA which shows a A35D/A280 ratio of below 0.015, when formulated into a 25% solution of said albumin.

摘要翻译： 本发明提供了通过加热含有rHSA和产生rHSA的宿主大肠杆菌的培养基来纯化重组人血清白蛋白（rHSA）的方法，将所述加热溶液向上加入到流化床中，其中吸附剂颗粒悬浮以与吸附剂接触 颗粒，然后回收含有rHSA的吸附级分，以及包含rHSA的组合物，其在配制成所述白蛋白的25％溶液时显示A35D / A280比率低于0.015。

公开(公告)号：US5710253A

公开(公告)日：1998-01-20

申请号：US358302

申请日：1994-12-19

申请人： Wataru Ohtani ,  Naoto Furuhata ,  Akinori Sumi ,  Munehiro Noda ,  Takao Ohmura

发明人： Wataru Ohtani ,  Naoto Furuhata ,  Akinori Sumi ,  Munehiro Noda ,  Takao Ohmura

IPC分类号： C12P21/00 ,  A61K38/16 ,  A61P7/00 ,  C07K1/14 ,  C07K1/20 ,  C07K14/76 ,  C07K14/765 ,  C12N15/00 ,  C12R1/84 ,  C07K1/36 ,  A61K38/38 ,  C07K1/16

CPC分类号： C07K14/765

摘要： A method for decoloring a recombinant human serum albumin by treating the albumin with a reducing agent is disclosed. Also, a method for decoloring a recombinant human serum albumin by treating the albumin with a method removing free polysaccharides with a cation exchanger followed by heat treatment is disclosed. The present invention provides a recombinant human serum albumin, coloring of which is fully suppressed by preventing binding of certain coloring components, which are contained in the raw materials or contaminants secreted by a microorganism, to human serum albumin so as not to cause coloring of the human serum albumin.

摘要翻译： 公开了通过用还原剂处理白蛋白来使重组人血清白蛋白脱色的方法。 另外，公开了一种通过用阳离子交换剂随后热处理除去游离多糖的方法处理白蛋白来对重组人血清白蛋白进行脱色的方法。 本发明提供一种重组人血清白蛋白，通过防止原料中含有的某些着色成分或微生物分泌的污染物与人血清白蛋白结合，使其着色得到完全抑制，从而不引起 人血清白蛋白。

公开(公告)号：US5656729A

公开(公告)日：1997-08-12

申请号：US374719

申请日：1995-04-28

申请人： Naoto Fuluhata ,  Akinori Sumi ,  Takao Ohmura

发明人： Naoto Fuluhata ,  Akinori Sumi ,  Takao Ohmura

IPC分类号： C07K14/76 ,  C07K1/16 ,  C07K1/20 ,  C07K14/765 ,  C12N15/09 ,  C12N15/81 ,  C12P21/00 ,  C12P21/02 ,  C12R1/84

CPC分类号： C07K14/765 ,  C12N15/815

摘要： A method for highly purifying human serum albumin (HSA), which comprises bringing a fraction containing HSA produced by genetic engineering into contact with a chelating chromatography carrier bound with copper ions, and eluting the HSA adsorbed by the carrier with a buffer containing ammonium chloride as an atagonist and having a pH of about 5-7.According to the method of the present invention, a component derived from yeast, which cannot be sufficiently removed by conventional purification methods for HSA produced by genetic engineering, can be removed from HSA produced by genetic engineering, and a highly purified HSA can be provided.

摘要翻译： PCT No.PCT / JP93 / 01048 Sec。 371日期：1995年4月28日 102（e）日期1995年4月28日PCT提交1993年7月26日PCT公布。 公开号WO94 / 03626 日期1994年2月17日一种用于高纯度人血清白蛋白（HSA）的方法，其包括使含有通过遗传工程产生的HSA的级分与与铜离子结合的螯合色谱载体接触，并用载体洗脱HSA 缓冲液含有氯化铵作为对策，pH约为5-7。 根据本发明的方法，通过遗传工程生产的HSA的常规纯化方法不能充分除去酵母成分，可以从由遗传工程生产的HSA中除去，可以提供高纯度的HSA。

公开(公告)号：US4694074A

公开(公告)日：1987-09-15

申请号：US792081

申请日：1985-10-28

申请人： Yahiro Uemura ,  Takao Ohmura ,  Akimasa Ohmizu ,  Akinori Sumi ,  Wataru Ohtani ,  Yoshitaka Sakanishi ,  Hiroshi Morise ,  Hirofumi Arimura ,  Tadakazu Suyama

发明人： Yahiro Uemura ,  Takao Ohmura ,  Akimasa Ohmizu ,  Akinori Sumi ,  Wataru Ohtani ,  Yoshitaka Sakanishi ,  Hiroshi Morise ,  Hirofumi Arimura ,  Tadakazu Suyama

IPC分类号： C12N15/09 ,  A61K39/29 ,  A61P1/16 ,  C07K1/16 ,  C07K1/22 ,  C07K14/005 ,  C07K14/02 ,  C07K14/195 ,  C07K14/435 ,  C12N5/00 ,  C12N15/00 ,  C12P21/00 ,  C12P21/08 ,  C07K3/18 ,  C07K3/28

CPC分类号： C07K14/005 ,  C12N2730/10122 ,  Y10S530/806 ,  Y10S530/808

摘要： A process for the purification of HBsAg is disclosed, which comprises adsorbing specifically on a carrier, in the presence of an inorganic salt in an amount of 5 to 25 W/V %, an HBsAg obtained by gene engineering.

摘要翻译： 公开了一种用于纯化HBsAg的方法，其包括在载体上以5至25W / V％的无机盐存在下特异性吸附通过基因工程获得的HBsAg。

公开(公告)号：US5440018A

公开(公告)日：1995-08-08

申请号：US36387

申请日：1993-03-24

申请人： Takao Ohmura ,  Akinori Sumi ,  Wataru Ohtani ,  Naoto Fuluhata ,  Kazuya Takeshima ,  Kaeko Kamide ,  Munehiro Noda ,  Masahide Kondo ,  Syoichi Ishikawa ,  Kazuhiro Oohara ,  Kazumasa Yokoyama

发明人： Takao Ohmura ,  Akinori Sumi ,  Wataru Ohtani ,  Naoto Fuluhata ,  Kazuya Takeshima ,  Kaeko Kamide ,  Munehiro Noda ,  Masahide Kondo ,  Syoichi Ishikawa ,  Kazuhiro Oohara ,  Kazumasa Yokoyama

IPC分类号： A61K38/00 ,  C07K1/14 ,  C07K14/765 ,  C12N15/14 ,  A61K38/38 ,  C07K1/16 ,  C07K1/36

CPC分类号： C07K14/765 ,  A61K38/00

摘要： Human serum albumin obtained by gene manipulation techniques can be purified by a combination of specified steps in which a culture supernatant obtained from a human serum albumin-producing host is subjected to ultrafiltration, heat treatment, acid treatment and another ultrafiltration, followed by subsequent treatments with a cation exchanger, a hydrophobic chromatography carrier and an anion exchanger, and by salting-out to thereby obtain a pure form of human serum albumin which contains substantially no proteinous and polysaccharide contaminants, which is formulated into a pharmaceutical preparation. This process makes it possible to effeciently purify recombinant human serum albumin and to provide substantially pure human serum albumin which does not contain producer host-related substances and other contaminants and is sufficiently free from coloration.

摘要翻译： 通过基因操作技术获得的人血清白蛋白可以通过特定步骤的组合来纯化，其中将得自人血清白蛋白的宿主的培养上清液进行超滤，热处理，酸处理和另一次超滤，然后用 阳离子交换剂，疏水性色谱载体和阴离子交换剂，并通过盐析，从而获得纯的形式的人血清白蛋白，其基本上不含有配制成药物制剂的蛋白质和多糖污染物。 该方法使得可以有效地纯化重组人血清白蛋白并提供基本上纯的人血清白蛋白，其不含生产者宿主相关物质和其它污染物，并且没有着色。

公开(公告)号：US07428034B2

公开(公告)日：2008-09-23

申请号：US12015267

申请日：2008-01-16

申请人： Akinori Sumi ,  Yasuhiro Morii

发明人： Akinori Sumi ,  Yasuhiro Morii

IPC分类号： G02F1/1339

CPC分类号： G02F1/13394 ,  G02F1/134363 ,  G02F1/136209 ,  G02F1/136286 ,  G02F2001/136222

摘要： A liquid crystal display device has the first substrate and the second substrate. The first substrate includes a gate line, a source line crossing the gate line, a switching element connected to the source line, a liquid crystal drive electrode connected to the switching element and having a plurality of electrodes substantially parallel to each other, and a common electrode consisting of a plurality of comb-shaped electrodes arranged substantially parallel to and alternately with the liquid crystal drive electrode. The second substrate includes color filters arranged in an array arrangement and a black matrix provided between the color filters. A spacer between the substrates contacts the first substrate in the area where the gate line, the liquid crystal drive electrode, and the common electrode are arranged in the vicinity of each other.

公开(公告)号：US20050046779A1

公开(公告)日：2005-03-03

申请号：US10438971

申请日：2003-05-16

申请人： Akinori Sumi ,  Yasuhiro Morii

发明人： Akinori Sumi ,  Yasuhiro Morii

IPC分类号： G02F1/1339 ,  G02F1/1343 ,  G02F1/1362

CPC分类号： G02F1/13394 ,  G02F1/134363 ,  G02F1/136209 ,  G02F1/136286 ,  G02F2001/136222

摘要： A liquid crystal display device has the first substrate and the second substrate. The first substrate includes a gate line, a source line crossing the gate line, a switching element connected to the source line, a liquid crystal drive electrode connected to the switching element and having a plurality of electrodes substantially parallel to each other, and a common electrode consisting of a plurality of comb-shaped electrodes arranged substantially parallel to and alternately with the liquid crystal drive electrode. The second substrate includes color filters arranged in an array arrangement and a black matrix provided between the color filters. A spacer between the substrates contacts the first substrate in the area where the gate line, the liquid crystal drive electrode, and the common electrode are arranged in the vicinity of each other.

摘要翻译： 液晶显示装置具有第一基板和第二基板。 第一基板包括栅极线，与栅极线交叉的源极线，连接到源极线的开关元件，连接到开关元件并具有彼此大致平行的多个电极的液晶驱动电极，以及共同的 电极由与液晶驱动电极大致平行且交替配置的多个梳状电极构成。 第二基板包括以阵列布置布置的滤色器和设置在滤色器之间的黑矩阵。 衬底之间的间隔件在栅极线，液晶驱动电极和公共电极彼此附近的区域中接触第一衬底。