摘要:
The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models. The derivatives can be effectively used for the prevention and treatment of ischemic heart diseases such as myocardiac infarction, arrhythmia, angina pectoris and the like, and cerebrovascular diseases such as cerebral stroke and be used as cardioprotective agents to the patients undergoing reperfusion therapy including chemicals such as thrombolytic agents, or surgery such as coronary artery bypass and percutaneous transluminal coronary angioplasty.
摘要:
A wireless receiver for receiving a multi-contents file and a method for outputting data using the same, which can receive, navigation information for providing intuitively recognizable search interfaces to a user by radio in real time, receive various types of contents files by radio in real time, and output the received information and files through an AV device. A video decoder decodes a video stream on the basis of an MPEG standard. An audio decoder decodes an audio contents file. An OSD processor processes a text file and additional information. A video output unit selectively configures decoded video data and text data on one screen and performs encoding and outputting operations based on the format of a display unit. An audio output unit outputs decoded audio data. A user interface receives a user's command. A WLAN card communicates WLAN data with a computer system. A controller requests the computer system to transmit navigation screen information, at least one contents file or additional information of the contents file edited and processed by the computer system, analyzes a data stream received by radio from the computer system responsive to the request, and performs a control operation so that a result of the analysis is inputted into the decoder or OSD processor. A memory stores the stream and control program data.
摘要:
Disclosed herein are a lightweight silicone implant which is manufactured by filling a foamed silicone sponge and/or vacant silicone capsules in a silicone bag or a cohesive gel bag and sealing the bag, and a method for manufacturing the same.
摘要:
The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same.Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be effectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.
摘要:
The present invention relates to benzopyran derivatives substituted with secondary amines including tetrazole, method for preparing thereof and pharmaceutical compositions containing them. The compounds of the present invention can be used for protecting neuronal cells and brain damage; antioxidation; inhibiting NO generation; protecting heart; suppressing angiogenesis; protecting preserving organs such as kidney, heart and tissue, and protecting organs in major cardiovascular surgery.
摘要:
Novel imidazole derivatives of formula(I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity: ##STR1## wherein: A is a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl group, or OR.sub.1 wherein R.sub.1 is a hydrogen, or a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical; B is a halogen, CF.sub.3 or CF.sub.2 CF.sub.3 ; X is N or N-oxide; Y is --CH.sub.2 --, --CH(OR.sub.1)-- wherein R.sub.1 is the same as defined above, or --C(.dbd.O)--; n is 0 or an integer of 1 to 4; Z is a halogen, --OH, --OR.sub.1, --NR.sub.1 R.sub.2, --N(.dbd.O)R.sub.3 R.sub.4, --C(.dbd.O)R.sub.1, --C(.dbd.O)OR.sub.1, --CH(OR.sub.1).sub.2 or --C(.dbd.O)N.sub.1 N.sub.2 wherein R.sub.1 is the same as defined above, R.sub.2 is, independently of R.sub.1, a hydrogen, or a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical, and R.sub.3 and R.sub.4 are independently a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical; and D is a hydrogen, or a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical.
摘要:
The present invention is directed to a novel imidazole derivative having an aryl piperidine substituent of formula (I) and a method for preparation thereof, and a pharmaceutical composition containing said imidazole derivative as an active ingredient for preventing or treating a MCH (melanine-concentrating hormone)-related disease.
摘要:
A hydraulic circuit is provided, which can prevent the bucket from being separated from the bucket rest by preventing a change of stroke of a boom cylinder or an arm cylinder during long traveling of wheel type heavy equipment, and can secure safety since it is not required for an operator to adjust the position of a working device like boom and arm. The hydraulic circuit includes first and second hydraulic pumps, a boom cylinder, an arm cylinder, a boom confluence logic valve, a first port formed to connect with a large chamber of the boom cylinder in a housing in which a spool for the boom cylinder is shiftably installed, a second port formed to connect with a hydraulic tank in the housing, and a first orifice formed between the housing and a land part of the spool for the boom cylinder located between the first port and the second port. During long traveling of the heavy equipment, a very small amount of hydraulic fluid fed from the second hydraulic pump to the large chamber of the boom cylinder drains to the hydraulic tank through the first orifice to prevent a change of stroke of the boom cylinder.
摘要:
A surgical cast cutter for removing orthopedic bandages of a hard casting material type comprises a first shank (2a), cutting portion (2b), and second shank (2c); a first housing (1) having a built-in rotating device which rotates the cutting tool; a tool holding device which rotatably holds the cutting tool (2); a second housing (15) which receives the cutting tool (2) and having an integrated horseshoe-shaped protrusion which is inserted between the hard cover and affected area as a guide such that the hard cover may be easily cut; and a hood (50) which is coupled to the second housing (15) and movable in the up and down direction. The hood also serves as a collecting device for collecting dusts and debris formed from the removal of the cast. A method is also disclosed for applying the cast on an affected area such that it may be easily removed by the cast cutter.