公开(公告)号：US20230277687A1

公开(公告)日：2023-09-07

申请号：US18006056

申请日：2021-08-06

申请人： Fundacion Para La Investigacion Medica Aplicada ,  CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DEL ÁREA DE ENFERMEDADES NEURODEGENERATIVAS M.P C ,  UCB BIOPHARMA SRL

发明人： Gloria GONZÁLEZ-ASEGUINOLAZA ,  Diego SUCUNZA GUIBERT ,  José Luis LANCIEGO PÉREZ ,  Ralph Michael LINDEN

IPC分类号： A61K48/00 ,  C12N9/24 ,  C12N15/86 ,  A61K38/47 ,  A61K49/00 ,  A61P25/28

CPC分类号： A61K48/0058 ,  C12N9/2402 ,  C12Y302/01045 ,  C12N15/86 ,  A61K38/47 ,  A61K48/0041 ,  A61K49/0004 ,  A61P25/28 ,  C12N2750/14143 ,  C12N2750/14171

摘要： The present disclosure relates to viral particles for use in treating tauopathies, particularly Alzheimer's disease, by gene therapy. More specifically, the present invention relates to a viral particle for use in treating tauopathies by gene therapy in a subject in need thereof, said viral particle comprising a nucleic acid construct including a transgene encoding a glucocerebro sidase.