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公开(公告)号:US07196090B2
公开(公告)日:2007-03-27
申请号:US10621983
申请日:2003-07-17
申请人: Cleo J. Chivikas Connolly , Christopher James Deur , James Marino Hamby , Denton Wade Hoyer , Chris Limberakis , Jessica Elizabeth Reed , Mel Conrad Schroeder , Clarke Taylor
发明人: Cleo J. Chivikas Connolly , Christopher James Deur , James Marino Hamby , Denton Wade Hoyer , Chris Limberakis , Jessica Elizabeth Reed , Mel Conrad Schroeder , Clarke Taylor
IPC分类号: A01N43/54 , A61K31/505 , C07D487/00
CPC分类号: C07D487/04
摘要: This invention provides phenyl-substituted pyrimidopyrimidines, dihydropyrimido-pyrimidines, pyridopyrimidines, naphthyridines, and pyridopyrazines of the general formula: that inhibit cyclin-dependent kinase and tyrosine kinase enzymes, methods and intermediate compounds for their synthesis, as well as pharmaceutical compositions and methods for their use in treating, inhibiting or preventing maladies associated with cell proliferative disorders, including angiogenesis, atherosclerosis, restenosis, and cancer.
摘要翻译: 本发明提供了以下通式的苯基取代的嘧啶并嘧啶,二氢嘧啶并嘧啶,吡啶并嘧啶,萘啶和吡啶并吡嗪,
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公开(公告)号:US06605617B2
公开(公告)日:2003-08-12
申请号:US09951265
申请日:2001-09-11
申请人: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Elisa Jazan
发明人: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Elisa Jazan
IPC分类号: C07D47104
CPC分类号: C07D409/04 , A61K31/19 , A61K31/4709 , A61K31/4745 , A61K31/513 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D417/04 , C07D453/02 , C07D471/04 , A61K2300/00
摘要: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
摘要翻译: 提供具有式I和II的有机化合物,其中变量具有本文所述的值。药物制剂包括有机化合物或其药学上可接受的盐和药学上可接受的载体,并且可以通过将有机化合物或其药学上可接受的盐 有机化合物与载体和水。 治疗患者的方法包括向有需要的患者施用本发明的药物制剂。
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公开(公告)号:US20100184754A1
公开(公告)日:2010-07-22
申请号:US12651612
申请日:2010-01-04
申请人: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, JR. , Christopher McBride , Elisa Jazan
发明人: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, JR. , Christopher McBride , Elisa Jazan
IPC分类号: A61K31/541 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61P35/04
CPC分类号: C07D471/04 , A61K31/19 , A61K31/439 , A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/513 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D453/02 , A61K2300/00
摘要: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
摘要翻译: 提供具有式I和II的有机化合物,其中变量具有本文所述的值。 药物制剂包括有机化合物或其药学上可接受的盐和药学上可接受的载体,并且可以通过将有机化合物的有机化合物或药学上可接受的盐与载体和水混合来制备。 治疗患者的方法包括向有需要的患者施用本发明的药物制剂。
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公开(公告)号:US06800760B2
公开(公告)日:2004-10-05
申请号:US10613411
申请日:2003-07-03
申请人: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Elisa Jazan
发明人: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Elisa Jazan
IPC分类号: C07D21516
CPC分类号: C07D409/04 , A61K31/19 , A61K31/4709 , A61K31/4745 , A61K31/513 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D417/04 , C07D453/02 , C07D471/04 , A61K2300/00
摘要: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
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公开(公告)号:US06762194B2
公开(公告)日:2004-07-13
申请号:US10387355
申请日:2003-03-12
申请人: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Eliza Jazan
发明人: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Eliza Jazan
IPC分类号: A61K3147
CPC分类号: C07D409/04 , A61K31/19 , A61K31/4709 , A61K31/4745 , A61K31/513 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D417/04 , C07D453/02 , C07D471/04 , A61K2300/00
摘要: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
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公开(公告)号:US07598268B2
公开(公告)日:2009-10-06
申请号:US10886950
申请日:2004-07-08
申请人: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea , Christopher McBride , Elisa Jazan
发明人: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea , Christopher McBride , Elisa Jazan
IPC分类号: A61K31/44
CPC分类号: C07D409/04 , A61K31/19 , A61K31/4709 , A61K31/4745 , A61K31/513 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D417/04 , C07D453/02 , C07D471/04 , A61K2300/00
摘要: Organic compounds having the formula I are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
摘要翻译: 提供具有式I的有机化合物,其中变量具有本文所述的值。 药物制剂包括有机化合物或其药学上可接受的盐和药学上可接受的载体,并且可以通过将有机化合物的有机化合物或药学上可接受的盐与载体和水混合来制备。 治疗患者的方法包括向有需要的患者施用本发明的药物制剂。
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公开(公告)号:US20080070906A1
公开(公告)日:2008-03-20
申请号:US11866296
申请日:2007-10-02
申请人: Paul Renhowe , Sabina Pecchi , Timothy Machajewski , Cynthia Shafer , Clarke Taylor , William McCrea , Christopher McBride , Elisa Jazan
发明人: Paul Renhowe , Sabina Pecchi , Timothy Machajewski , Cynthia Shafer , Clarke Taylor , William McCrea , Christopher McBride , Elisa Jazan
IPC分类号: A61K31/4709 , A61K31/439 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号: C07D471/04 , A61K31/19 , A61K31/439 , A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/513 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D453/02 , A61K2300/00
摘要: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
摘要翻译: 提供具有式I和II的有机化合物,其中变量具有本文所述的值。 药物制剂包括有机化合物或其药学上可接受的盐和药学上可接受的载体,并且可以通过将有机化合物的有机化合物或药学上可接受的盐与载体和水混合来制备。 治疗患者的方法包括向有需要的患者施用本发明的药物制剂。
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公开(公告)号:US20050096278A1
公开(公告)日:2005-05-05
申请号:US10936224
申请日:2004-09-08
IPC分类号: A61P31/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04 , C07D498/06 , C07F5/02 , A61K31/4745 , A61K31/69 , A61K38/04 , C07D471/02 , C07K5/04
CPC分类号: C07D401/14 , C07D401/04 , C07D405/14 , C07D471/04
摘要: Compounds of formula I, II, III, IV, IV, and VI and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.
摘要翻译: 公开了式I,II,III,IV,IV和VI的化合物及其制备方法。 还公开了制备式I的生物活性化合物的方法以及包含式I化合物的药学上可接受的组合物的方法。本文公开的式I化合物可用于多种应用,包括用作抗菌剂。
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公开(公告)号:US20050054672A1
公开(公告)日:2005-03-10
申请号:US10886950
申请日:2004-07-08
申请人: Paul Renhowe , Sabina Pecchi , Timothy Machajewski , Cynthia Shafer , Clarke Taylor , William McCrea , Christopher McBride , Elisa Jazan
发明人: Paul Renhowe , Sabina Pecchi , Timothy Machajewski , Cynthia Shafer , Clarke Taylor , William McCrea , Christopher McBride , Elisa Jazan
IPC分类号: C07D243/08 , A61K31/19 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P35/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D453/02 , C07D471/04 , C07D487/08 , C07D519/00 , C07D43/04
CPC分类号: C07D409/04 , A61K31/19 , A61K31/4709 , A61K31/4745 , A61K31/513 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D417/04 , C07D453/02 , C07D471/04 , A61K2300/00
摘要: Organic compounds having the formula I are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
摘要翻译: 提供具有式I的有机化合物,其中变量具有本文所述的值。 药物制剂包括有机化合物或其药学上可接受的盐和药学上可接受的载体,并且可以通过将有机化合物的有机化合物或药学上可接受的盐与载体和水混合来制备。 治疗患者的方法包括向有需要的患者施用本发明的药物制剂。
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公开(公告)号:US06774237B2
公开(公告)日:2004-08-10
申请号:US10284017
申请日:2002-10-30
申请人: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Elisa Jazan
发明人: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Elisa Jazan
IPC分类号: C07D21516
CPC分类号: C07D409/04 , A61K31/19 , A61K31/4709 , A61K31/4745 , A61K31/513 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D417/04 , C07D453/02 , C07D471/04 , A61K2300/00
摘要: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
摘要翻译: 提供具有式I和II的有机化合物,其中变量具有本文所述的值。药物制剂包括有机化合物或其药学上可接受的盐和药学上可接受的载体,并且可以通过将有机化合物或其药学上可接受的盐 有机化合物与载体和水。 治疗患者的方法包括向有需要的患者施用本发明的药物制剂。
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