公开(公告)号：US06287295B1

公开(公告)日：2001-09-11

申请号：US09121878

申请日：1998-07-24

申请人： Guohua Chen ,  Scott D. Lautenbach ,  Keith E. Dionne ,  Scott D. Jordan ,  Steve A. Berry ,  Craig I. Rodenberger ,  Rupal Ayer

发明人： Guohua Chen ,  Scott D. Lautenbach ,  Keith E. Dionne ,  Scott D. Jordan ,  Steve A. Berry ,  Craig I. Rodenberger ,  Rupal Ayer

IPC分类号： A61K922

CPC分类号： A61K9/0004

摘要： Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.

摘要翻译： 渗透输送系统半透性体组件，其从包含半透性体组件的渗透输送系统中控制有益剂的输送速率。 半透性体组件或塞子包括半渗透体，其可定位在渗透递送系统的开口中。 半透明体具有中空的内部部分，其具有选择的尺寸以获得通过半透性体的预定液体渗透速率。 由于渗透输送系统中的有益剂以基本上相同的速率递送，所以渗透剂吸收从周围环境渗透通过塞子的液体，通过塞子的液体渗透速率控制有益剂从渗透压的输送速率 输送系统。 可以改变通过半透性体的液体渗透速率，以通过改变半透性体的厚度或通过改变暴露于液体的半透明体的表面积的量来控制有益剂从渗透递送系统的输送速率， 渗透输送系统位于使用的液体环境中。

公开(公告)号：US06923800B2

公开(公告)日：2005-08-02

申请号：US09859428

申请日：2001-05-18

申请人： Guohua Chen ,  Scott D. Lautenbach ,  Keith E. Dionne ,  Scott D. Jordan ,  Steve A. Berry ,  Craig I. Rodenberger ,  Rupal Ayer

发明人： Guohua Chen ,  Scott D. Lautenbach ,  Keith E. Dionne ,  Scott D. Jordan ,  Steve A. Berry ,  Craig I. Rodenberger ,  Rupal Ayer

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/24 ,  A61K9/52

CPC分类号： A61K9/0004

摘要： Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies are provided. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate, the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, and the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.