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公开(公告)号:US09725500B2
公开(公告)日:2017-08-08
申请号:US13581236
申请日:2011-02-28
申请人: Robert Lyon , Dennis Benjamin , Maureen Ryan
发明人: Robert Lyon , Dennis Benjamin , Maureen Ryan
CPC分类号: C07K16/00 , A61K47/6803 , C07K1/04 , C07K2317/24 , G01N33/5014 , G01N33/533
摘要: The invention provides methods for making antibody conjugates for use in antibody screening assays and antibody conjugates produced by the claimed methods.
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公开(公告)号:US08598089B2
公开(公告)日:2013-12-03
申请号:US13040674
申请日:2011-03-04
申请人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffan Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
发明人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffan Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
CPC分类号: C07H21/00 , C12N15/1068 , C40B50/10
摘要: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
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公开(公告)号:US08410028B2
公开(公告)日:2013-04-02
申请号:US13051314
申请日:2011-03-18
申请人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffan Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
发明人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffan Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
CPC分类号: C12N15/1068 , C07H21/00 , C40B50/10
摘要: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
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公开(公告)号:US20120245040A1
公开(公告)日:2012-09-27
申请号:US13040674
申请日:2011-03-04
申请人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
发明人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
CPC分类号: C07H21/00 , C12N15/1068 , C40B50/10
摘要: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
摘要翻译: 本发明提供合成包含编码寡核苷酸标签的分子文库的方法。
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公开(公告)号:US07972992B2
公开(公告)日:2011-07-05
申请号:US11015458
申请日:2004-12-17
申请人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
发明人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
IPC分类号: C40B50/00
CPC分类号: C07H21/00 , C12N15/1068 , C40B50/10
摘要: The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an initiator compound comprising an initial functional moiety comprising n building blocks, wherein the initial functional moiety comprises at least one reactive group, and is operatively linked to an initial oligonucleotide; reacting the initiator compound with a building block comprising at least one complementary reactive group, under conditions suitable for reaction of the complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide with an incoming oligonucleotide corresponding to the building block in the presence of an enzyme which catalyzes ligation of the initial oligonucleotide and the incoming oligonucleotide, under conditions suitable for ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.
摘要翻译: 本发明提供合成包含与编码寡核苷酸有效连接的功能部分的分子的方法。 所述方法包括提供包含起始功能部分的引发剂化合物,其包含n个结构单元,其中所述初始功能部分包含至少一个反应性基团,并且可操作地连接到初始寡核苷酸; 使引发剂化合物与包含至少一个互补反应性基团的构建块在适于互补反应性基团反应以形成共价键的条件下反应; 并在初始寡核苷酸和入侵寡核苷酸的连接酶存在下,使初始寡核苷酸与对应于构建单元的入侵寡核苷酸反应,在适合连接引入寡核苷酸和初始寡核苷酸的条件下形成编码寡核苷酸 。
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公开(公告)号:US20070042401A1
公开(公告)日:2007-02-22
申请号:US11450938
申请日:2006-06-09
申请人: Barry Morgan , Stephen Hale , Christopher Arico-Muendel , Matthew Clark , Richard Wagner , David Israel , Malcolm Gefter , Dennis Benjamin , Nils Hansen , Malcolm Kavarana , Steffen Creaser , George Franklin , Paolo Centrella , Raksha Acharya
发明人: Barry Morgan , Stephen Hale , Christopher Arico-Muendel , Matthew Clark , Richard Wagner , David Israel , Malcolm Gefter , Dennis Benjamin , Nils Hansen , Malcolm Kavarana , Steffen Creaser , George Franklin , Paolo Centrella , Raksha Acharya
CPC分类号: C12N15/1068 , C07H21/00 , C40B50/10
摘要: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
摘要翻译: 本发明提供合成包含编码寡核苷酸标签的分子文库的方法。
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公开(公告)号:US09073993B2
公开(公告)日:2015-07-07
申请号:US13530074
申请日:2012-06-21
CPC分类号: A61K47/6803 , A61K38/05 , A61K47/6811 , A61K47/6849 , A61K47/6867 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/423
摘要: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.
摘要翻译: 本发明尤其涉及CD19结合剂和使用这种CD19结合剂来治疗疾病的方法。
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公开(公告)号:US20120322686A1
公开(公告)日:2012-12-20
申请号:US13581236
申请日:2011-02-28
申请人: Robert Lyon , Dennis Benjamin , Maureen Ryan
发明人: Robert Lyon , Dennis Benjamin , Maureen Ryan
CPC分类号: C07K16/00 , A61K47/6803 , C07K1/04 , C07K2317/24 , G01N33/5014 , G01N33/533
摘要: The invention provides methods for making antibody conjugates for use in antibody screening assays and antibody conjugates produced by the claimed methods.
摘要翻译: 本发明提供用于制备用于抗体筛选测定的抗体缀合物的方法和通过所要求保护的方法产生的抗体缀合物。
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公开(公告)号:US07935658B2
公开(公告)日:2011-05-03
申请号:US11906939
申请日:2007-10-04
申请人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
发明人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
IPC分类号: C40B30/10
CPC分类号: C07H21/00 , C12N15/1068 , C40B50/10
摘要: The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods generally include providing a solution comprising initiator compounds comprising an initial functional moiety which comprises n building blocks which comprise at least one reactive group, which is operatively linked to an initial oligonucleotide; dividing the solution into reaction vessels; reacting the initiator compounds in each reaction vessel with a building block comprising a complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide in each aliquot with a distinct incoming oligonucleotide in the presence of an enzyme which catalyzes the ligation of the incoming oligonucleotide and the initial oligonucleotide, under conditions suitable for enzymatic ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide which identifies the structure of the functional moiety.
摘要翻译: 本发明提供合成文库的方法,所述分子文库包括与编码寡核苷酸有效连接的功能部分。 方法通常包括提供包含引发剂化合物的溶液,其包含初始功能部分,其包含n个构建块,其包含至少一个与初始寡核苷酸有效连接的反应性基团; 将溶液分解成反应容器; 使每个反应容器中的引发剂化合物与包含互补反应性基团的构建块反应形成共价键; 并且在适合于引入寡核苷酸和初始寡核苷酸的酶连接的条件下,在催化引入的寡核苷酸和初始寡核苷酸的连接的酶存在下,使各等分试样中的初始寡核苷酸与不同的入侵寡核苷酸反应,形成编码 识别功能部分结构的寡核苷酸。
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公开(公告)号:US20090136526A1
公开(公告)日:2009-05-28
申请号:US12253895
申请日:2008-10-17
申请人: Charlotte McDonagh , Charles G. Cerveny , Dennis Benjamin , Paul Carter , Hans-Peter Gerber , Leigh Francisco
发明人: Charlotte McDonagh , Charles G. Cerveny , Dennis Benjamin , Paul Carter , Hans-Peter Gerber , Leigh Francisco
IPC分类号: A61K39/395 , C07K16/18 , C12N15/11
CPC分类号: A61K47/6803 , A61K38/05 , A61K47/6811 , A61K47/6849 , A61K47/6867 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/423
摘要: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.
摘要翻译: 本发明尤其涉及CD19结合剂和使用这种CD19结合剂来治疗疾病的方法。
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